축산식품과학과 산업

  • 제9권2호
  • /
  • Pages.58-65
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  • 2020
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  • 2287-3686(pISSN)
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  • 2635-4594(eISSN)
한국축산식품학회 (Korean Society for Food Science of Animal Resources)
권호 표지

마우스 모델에서 Gouda Cheese 섭취에 따른 만성 스트레스 개선 효과

Ingestion of Gouda Cheese Ameliorates the Chronic Unpredictable Mild Stress in Mice

  • 강민경 (전주대학교 의과학대학 바이오기능성식품학과) ;
  • 윤보현 (전북대학교 농업생명과학대학 우유유전체연구소) ;
  • 오상남 (전주대학교 의과학대학 바이오기능성식품학과)
  • Kang, Min Kyoung (Department of Functional Food and Biotechnology, Jeonju University) ;
  • Yun, Bohyun (Department of Animal Science and Institute of Milk Genomics, Jeonbuk National University) ;
  • Oh, Sangnam (Department of Functional Food and Biotechnology, Jeonju University)
  • 발행 : 2020.10.31
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⟨ 이전 논문 다음 논문 ⟩

초록

우울증은 동기, 의욕, 관심, 주의력, 정신기능 및 식욕의 감소를 특징으로 하는 일종의 기분 장애이다. 우울증은 유전적, 내분비 및 환경적 스트레스를 포함한 다양한 원인에 의해 발생하지만 가벼운 우울증은 식이요법으로 개선되는 것으로 보고되었다. 따라서 우울증 환자를 치료하기 위해서는 기능성 및 영양 보충제를 포함한 다양한 식품 공급원이 필요하다. 치즈에는 숙주 건강에 유익한 영향을 미치는 생리 활성 펩타이드가 포함되어 있다. 특히 저지(Jersey) 우유는 홀스타인(Holstein) 우유보다 고형분 함량이 높은 것으로 보고되었다. 이 연구는 저지(Jersey) 와 홀스타인(Holstein) 우유의 가우다 치즈(Gouda cheese)가 만성 스트레스(CUMS, chronic unpredictable mild stress)에 미치는 영향을 조사했다. 치즈를 먹인 만성 스트레스 마우스 모델의 개선적 변화는 젖소 종에 관계없이 통계적으로 유의미하게 효과적으로 나타났다. 흥미롭게도 PCR을 통한 분변 미생물 균총 분석에서 저지 치즈를 섭취함으로써 Bacteroidetes가 증가하고 Firmicutes가 유의적으로 감소하는 것으로 나타났다. 종합하면, 본 연구는 치즈 섭취가 스트레스 개선 작용이 있음을 제시하며, 특히 장내 미생물 균총의 유익한 방향으로의 변화가 관찰되는데, 치즈의 생리활성물질 혹은 장내미생물 균총의 대사물질들이 이러한 행동·정신학적 개선 작용과의 연관성이 있음을 시사한다.

키워드

참고문헌

  1. Apostolidis E, Kwon YI, Shetty K. 2007. Inhibitory potential of herb, fruit, and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension. Innov Food Sci Emerg Technol 8:46-54. https://doi.org/10.1016/j.ifset.2006.06.001
  2. Bangasser DA, Valentino RJ. 2014. Sex differences in stress-related psychiatric disorders: Neurobiological perspectives. Front Neuroendocrinol 35:303-319. https://doi.org/10.1016/j.yfrne.2014.03.008
  3. Bermudez-Humaran LG, Salinas E, Ortiz GG, Ramirez-Jirano LJ, Morales JA, Bitzer-Quintero OK. 2019. From probiotics to psychobiotics: Live beneficial bacteria which act on the brain-gut axis. Nutrients 11:890. https://doi.org/10.3390/nu11040890
  4. Bland J, Bailey AP, Grandison AS, Fagan CC. 2015a. Estimation of the financial benefit of using jersey milk at different inclusion rates for cheddar cheese production using partial budgeting. J Dairy Sci 98:1661-1665. https://doi.org/10.3168/jds.2014-8723
  5. Bland J, Grandison A, Fagan C. 2015b. Effect of blending jersey and Holstein-Friesian milk on cheddar cheese processing, composition, and quality. J Dairy Sci 98:1-8. https://doi.org/10.3168/jds.2014-8433
  6. Bobbo T, Roveglia C, Penasa M, Visentin G, Finocchiaro R, Cassandro M. 2019. Genetic relationships of alternative somatic cell count traits with milk yield, composition and udder type traits in Italian Jersey cows. Anim Sci J 90:808-817. https://doi.org/10.1111/asj.13204
  7. Casarotto P, Andreatini R. 2007. Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone. Eur Neuropsychopharmacol 17:735-742. https://doi.org/10.1016/j.euroneuro.2007.03.001
  8. Conway V, Gauthier S, Pouliot Y. 2014. Buttermilk: Much more than a source of milk phospholipids. Anim Front 4:44-51. https://doi.org/10.2527/af.2014-0014
  9. Daskalopoulou M, George J, Walters K, Osborn DP, Batty GD, Stogiannis D, Rapsomaniki E, Pujades-Rodriguez M, Denaxas S, Udumyan R. 2016. Depression as a risk factor for the initial presentation of twelve cardiac, cerebrovascular, and peripheral arterial diseases: Data linkage study of 1.9 million women and men. PLOS ONE 11:e0153838. https://doi.org/10.1371/journal.pone.0153838
  10. Edgar W, Bowen W, Amsbaugh S, Monell-Torrens E, Brunelle J. 1982. Effects of different eating patterns on dental caries in the rat. Caries Res 16:384-389. https://doi.org/10.1159/000260624
  11. Ferris C, Purcell P, Gordon A, Larsen T, Vestergaard M. 2018. Performance of Holstein and Swedish-Red× Jersey/Holstein crossbred dairy cows within low-and medium-concentrate grassland-based systems. J Dairy Sci 101:7258-7273. https://doi.org/10.3168/jds.2017-14107
  12. Gomez-Ruiz JA, Taborda G, Amigo L, Recio I, Ramos M. 2006. Identification of ace-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. Eur Food Res Technol 223:595-601. https://doi.org/10.1007/s00217-005-0238-0
  13. Guo Y, Xie JP, Deng K, Li X, Yuan Y, Xuan Q, Xie J, He XM, Wang Q, Li JJ. 2019. Prophylactic effects of Bifidobacterium adolescentis on anxiety and depression-like phenotypes after chronic stress: A role of the gut microbiota-inflammation axis. Front Behav Neurosci 13.
  14. Hernell O, Timby N, Domellof M, Lonnerdal B. 2016. Clinical benefits of milk fat globule membranes for infants and children. J Pediatr 173:S60-S65. https://doi.org/10.1016/j.jpeds.2016.02.077
  15. Higurashi S, Kunieda Y, Matsuyama H, Kawakami H. 2007. Effect of cheese consumption on the accumulation of abdominal adipose and decrease in serum adiponectin levels in rats fed a calorie dense diet. Int Dairy J 17:1224-1231. https://doi.org/10.1016/j.idairyj.2007.03.012
  16. Jensen HB, Poulsen NA, Andersen KK, Hammershoj M, Poulsen HD, Larsen LB. 2012. Distinct composition of bovine milk from Jersey and Holstein-Friesian cows with good, poor, or noncoagulation properties as reflected in protein genetic variants and isoforms. J Dairy Sci 95:6905-6917. https://doi.org/10.3168/jds.2012-5675
  17. Kato K, Takada Y, Matsuyama H, Kawasaki Y, Aoe S, Yano H, Toba Y. 2002. Milk calcium taken with cheese increases bone mineral density and bone strength in growing rats. Biosci Biotechnol Biochem 66:2342-2346. https://doi.org/10.1271/bbb.66.2342
  18. Kim DH, Yoon BH, Kim YW, Lee S, Shin BY, Jung JW, Kim HJ, Lee YS, Choi JS, Kim SY. 2007. The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. J Pharmacol Sci 105:82-93. https://doi.org/10.1254/jphs.FP0061565
  19. Levinstein MR, Samuels BA. 2014. Mechanisms underlying the antidepressant response and treatment resistance. Front Behav Neurosci 8:208.
  20. Li N, Wang Q, Wang Y, Sun A, Lin Y, Jin Y, Li X. 2019. Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiotainflammation-brain axis. Stress:1-11.
  21. Lopez-Exposito I, Amigo L, Recio I. 2012. A mini-review on health and nutritional aspects of cheese with a focus on bioactive peptides. Dairy Sci Technol 92:419-438. https://doi.org/10.1007/s13594-012-0066-5
  22. Lotfaliany M, Bowe SJ, Kowal P, Orellana L, Berk M, Mohebbi M. 2018. Depression and chronic diseases: Cooccurrence and communality of risk factors. J Affect Disord 241:461-468. https://doi.org/10.1016/j.jad.2018.08.011
  23. Marin IA, Goertz JE, Ren T, Rich SS, Onengut-Gumuscu S, Farber E, Wu M, Overall CC, Kipnis J, Gaultier A. 2017. Microbiota alteration is associated with the development of stress-induced despair behavior. Sci Rep 7:43859. https://doi.org/10.1038/srep43859
  24. Martin CR, Osadchiy V, Kalani A, Mayer EA. 2018. The brain-gut-microbiome axis. Cell Mol Gastroenterol Hepatol 6:133-148. https://doi.org/10.1016/j.jcmgh.2018.04.003
  25. Milaneschi Y, Simmons WK, Van Rossum EF, Penninx BW. 2019. Depression and obesity: Evidence of shared biological mechanisms. Mol Psychiatry 24:18. https://doi.org/10.1038/s41380-018-0017-5
  26. Nagai K. 2012. Bovine milk phospholipid fraction protects neuro2a cells from endoplasmic reticulum stress via pkc activation and autophagy. J Biosci Bioeng 114:466-471. https://doi.org/10.1016/j.jbiosc.2012.05.009
  27. Nair BM, Prajapati JB. 2003. The history of fermented foods. In Handbook of fermented functional foods. CRC Press.
  28. Perez-Pardo P, Dodiya HB, Broersen LM, Douna H, Van Wijk N, Lopes Da Silva S, Garssen J, Keshavarzian A, Kraneveld AD. 2018. Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet. Nutr Neurosci 21:391-402. https://doi.org/10.1080/1028415x.2017.1294555
  29. Plante GE. 2005. Depression and cardiovascular disease: A reciprocal relationship. Metabolism 54:45-48. https://doi.org/10.1016/j.metabol.2005.01.013
  30. Saborio-Montero A, Vargas-Leiton B, Romero-Zuniga J, Camacho-Sandoval J. 2018. Additive genetic and heterosis effects for milk fever in a population of Jersey, Holstein× Jersey, and Holstein cattle under grazing conditions. J Dairy Sci 101:9128-9134. https://doi.org/10.3168/jds.2017-14234
  31. Schubert M, Contreras C, Franz N, Hellhammer J. 2011. Milk-based phospholipids increase morning cortisol availability and improve memory in chronically stressed men. Food Nutr 31:413-420.
  32. Thompson SM, Kallarackal AJ, Kvarta MD, Van Dyke AM, Legates TA, Cai X. 2015. An excitatory synapse hypothesis of depression. Trends Neurosci 38:279-294. https://doi.org/10.1016/j.tins.2015.03.003
  33. Verardo V, Gomez-Caravaca A, Arraez-Roman D, Hettinga K. 2017. Recent advances in phospholipids from colostrum, milk and dairy by-products. Int J Mol Sci 18:173. https://doi.org/10.3390/ijms18010173
  34. Walther B, Schmid A, Sieber R, Wehrmuller K. 2008. Cheese in nutrition and health. Dairy Sci Technol 88:389-405. https://doi.org/10.1051/dst:2008012
  35. White S, Bertrand J, Wade M, Washburn S, Green Jr J, Jenkins T. 2001. Comparison of fatty acid content of milk from Jersey and Holstein cows consuming pasture or a total mixed ration. J Dairy Sci 84:2295-2301. https://doi.org/10.3168/jds.S0022-0302(01)74676-0
  36. Yang YW, Chen MK, Yang BY, Huang XJ, Zhang XR, He LQ, Zhang J, Hua ZC. 2015. Use of 16s rrna genetargeted group-specific primers for real-time pcr analysis of predominant bacteria in mouse feces. Appl Environ Microbiol 81:6749-6756. https://doi.org/10.1128/AEM.01906-15
  37. Yasuda S, Kuwata H, Kawamoto K, Shirakawa J, Atobe S, Hoshi Y, Yamasaki M, Nishiyama K, Tachibana H, Yamada K. 2012. Effect of highly lipolyzed goat cheese on hl-60 human leukemia cells: Antiproliferative activity and induction of apoptotic DNA damage. J Dairy Sci 95:2248-2260. https://doi.org/10.3168/jds.2011-4153
  38. Yoo J, Song M, Park W, Oh S, Ham JS, Jeong SG, Kim Y. 2019. A comparison of quality characteristics in dairy products made from Jersey and Holstein milk. Food Sci Anim Resour 39:255. https://doi.org/10.5851/kosfa.2019.e20