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부산지역 여성의 고위험군 인유두종 바이러스 유병률과 유전자형 분석

Prevalence and Genotype Analysis of High Risk-human Papillomavirus Infection in Busan Women

  • 강창수 (부산의료원 병리과) ;
  • 이경은 (부산가톨릭대학교 임상병리학과)
  • Kang, Chang-Soo (Department of Pathology, Busan Medical Center) ;
  • Lee, Kyung Eun (Department of Clinical Laboratory Science, Catholic University of Pusan)
  • 투고 : 2019.10.12
  • 심사 : 2019.10.24
  • 발행 : 2019.11.30

초록

자궁경부암의 주요 원인은 인유두종 바이러스(HPV)로 알려져 있으며, 자궁경부암 환자의 99.7%에서 HPV DNA가 검출된다고 하였다. 또한 세계적으로 HPV 16 및 18의 유병률이 가장 높은 것으로 보고되고 있으나, 한국을 포함한 아시아에서는 HPV 52 및 58의 유병률이 더 높게 나타나고 있다. 따라서 본 연구에서는 부산지역 여성의 HPV 유병률과 고위험군 인유두종 바이러스(HR-HPV) 유전자형을 분석하여 자궁경부암 예방을 위한 기초 자료를 확보하고자 하였다. 2016년 1월부터 2017년 12월까지 부산 산부인과병원을 내원한 여성 중 HPV 유전자형 검사를 시행한 여성 1,995예를 대상으로 분석하였다. 본 연구에서는 부산지역 여성에서 28.3%(565/1995)의 HPV 유병률을 확인하였다. 특히 HR-HPV 감염률은 75.4%(426/565)로 높게 나타났으며, HR-HPV 유전자형은 52형(63/565, 11.2%)이 가장 높게 나타났고, 그 다음으로 58형(56/565, 9.9%), 53형(55/565. 9.7%), 16형(53/565, 9.4%) 순으로 나타났다. 또한 18~39세이하의 젊은 여성들의 HR-HPV 감염률이 60.3%(257/426)로 높게 나타나므로 지속적인 감시가 필요할 것으로 사료된다. 또한 세포학적 결과에서 자궁경부내 상피의 이상소견이 높아지는 HSIL과 SCC에서 HPV 16형이 높은 감염률을 보였으나, 향후 더 많은 검체를 이용하여 자궁경부내 종양 발생과 관련된 HR-HPV 유전자형을 확인해야 될 것으로 사료된다.

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