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Proper management of suspicious actinic cheilitis

  • Kim, Soung Min (Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital) ;
  • Myoung, Hoon (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Eo, Mi Young (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Cho, Yun Ju (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Lee, Suk Keun (Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University)
  • Received : 2018.11.26
  • Accepted : 2019.03.13
  • Published : 2019.12.31

Abstract

Background: Actinic cheilitis (AC) is a variant of actinic keratosis which is known to be a premalignant condition that could develop into squamous cell carcinoma (SCC). Epimyoepithelial carcinoma (EC) is a very rare salivary gland (SG) neoplasm that has classical biphasic histologic findings of small tubules and glandular lumina surrounded by clear myoepithelial cells. Case presentation: We report a very rare case of AC occurring on the lower lip of a 70-year-old woman, which is developing to the EC later. Conclusions: Diverse appearances of AC include edematous reddish in the acute stage and grey-whitish or dried hyperkeratotic wrinkled lesions in the chronic stage for several months or even years. Accurate treatment of AC in its initial stage could be recommended to avoid further malignant transformation; proper management of clinically suspicious AC is suggested.

Keywords

References

  1. Wikipedia, the free encyclopedia Center (2018) Wikipedia registered. https://en.wikipedia.org/wiki/Actinic_cheilitis. Accessed 25 Nov 2018
  2. Vieira RA, Minicucci EM, Marques ME, Marques SA (2012) Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects. An Bras Dermatol 87:105-114 https://doi.org/10.1590/S0365-05962012000100013
  3. Lokuhetty M, Premathilake I, Amarasinghe C (2011) Epimyoepithelial carcinoma - an uncommon salivary gland tumour. J Diag Pathol 3:25-27 https://doi.org/10.4038/jdp.v3i1.2993
  4. Corio RL, Sciubba JJ, Brannon RB, Batsakis JG (1982) Epithelial myoepithelial carcinoma of intercalated duct origin. A cliniopathologic and ultrastructural assessment of sixteen cases. Oral Surg Oral Med Oral Pathol 53:280-287 https://doi.org/10.1016/0030-4220(82)90304-8
  5. Donath K, Seifert G, Schmitz R (1972) Diagnose and unltrastrukturdes tubularen speichelgangcarcinomas Epithelial myoepitheliales schaltstustuckcarcinom. Virchows Arch 356:16-231 https://doi.org/10.1007/BF00543554
  6. Garcia NG, Oliveira DT, Lauris JR, Domingues MA, Minicucci EM, Soares C (2016) Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis. Clin Oral Investig 20:745-752 https://doi.org/10.1007/s00784-015-1557-6
  7. Li TJ, Zhang YX, Wen J, Cowan DF, Hart J, Xiao SY (2004) Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features. Arch Pathol Lab Med 128:1124-1130 https://doi.org/10.5858/2004-128-1124-BSCCOT
  8. Jang EJ, Kang SH, Bae YK (2014) Basaloid ductal carcinoma in situ arising in salivary gland metaplasia of the breast: a case report. Int J Clin Exp Pathol 15:6370-6374
  9. Jadotte YT, Schwartz RA (2012) Solar cheilosis. An ominous precursor Part II Diagnostic insights. J Am Acad Dermatol 66:187-198 https://doi.org/10.1016/j.jaad.2011.09.039
  10. Nico MM, Nakano de Melo J, Lourenco SV (2010) Cheilitis glandularis: a clinicopathological study in 22 patients. J Am Acad Dermatol 62:233-238 https://doi.org/10.1016/j.jaad.2009.06.038
  11. Muthukrishnan A, Bijai Kumar L (2017) Actinic cheilosis: early intervention prevents malignant transformation. BMJ Case Rep 20:2017
  12. Choi E, Tan KB, Chandran NS (2017) Isolated actinic lichen planus of the lower lip. Case Rep Dermatol 9:131-134 https://doi.org/10.1159/000471843
  13. Picascia DD, Robinson JK (1987) Actinic cheilitis: a review of the etiology, differential diagnosis, and treatment. J Am Acad Dermatol 17:255-264 https://doi.org/10.1016/S0190-9622(87)70201-1
  14. Bickle K, Roark TR, Hsu S (2002) Autoimmune bullous dermatoses: a review. Am Fam Physician 65:1861-1870
  15. El-Hakim M, Chauvin P (2004) Orofacial granulomatosis presenting as persistent lip swelling: review of 6 new cases. J Oral Maxillofac Surg 62:1114-1117 https://doi.org/10.1016/j.joms.2003.11.013
  16. Lubritz RR, Smolewski SA (1983) Cryosurgery cure rate of premalignant leukoplakia of the lower lip. J Dermatol Surg Oncol 9:235-237 https://doi.org/10.1111/j.1524-4725.1983.tb00794.x
  17. Czerninski R, Zini A, Sgan-Cohen HD (2010) Lip cancer: incidence, trends, histology and survival: 1970-2006. Br J Dermatol 162:1103-1109 https://doi.org/10.1111/j.1365-2133.2010.09698.x

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