DOI QR코드

DOI QR Code

형상학적 변수에 따른 다공성 구조의 가변탄성계수를 기반으로 한 추간체유합보형재의 임상적 안전성 평가

Clinical Safety Evaluation of Interbody Fusion Cage Based on Tunable Elastic Modulus of the Cellular Structure According to the Geometrical Variables

  • 김성진 (건양대학교 의료신소재학과) ;
  • 이용경 (세종대학교 기계공학) ;
  • 최재혁 (세종대학교 기계공학) ;
  • 홍영기 (건양대학교 의료신소재학과) ;
  • 김정성 ((주)코렌텍 중앙기술연구소)
  • Kim, SeongJin (Department of Biomedical Materials, Konyang University) ;
  • Lee, YongKyung (Department of Mechanical Engineering, Sejong University) ;
  • Choi, Jaehyuck (Department of Mechanical Engineering, Sejong University) ;
  • Hong, YoungKi (Department of Biomedical Materials, Konyang University) ;
  • Kim, JungSung (Central R&D center, CORENTEC CO., LTD)
  • 투고 : 2019.09.19
  • 심사 : 2019.10.10
  • 발행 : 2019.10.31

초록

The interbody fusion cage used to replace the degenerative intervertebral disc is largely composed of titanium-based biomaterials and biopolymer materials such as PEEK. Titanium is characterized by osseointergration and biocompatibility, but it is posed that the phenomenon such as subsidence can occur due to high elastic modulus versus bone. On the other hand, PEEK can control the elastic modulus in a similar to bone, but there is a problem that the osseointegration is limited. The purpose of this study was to implement titanium material's stiffness similar to that of bone by applying cellular structure, which is able to change the stiffness. For this purpose, the cellular structure A (BD, Body Diagonal Shape) and structure B (QP, Quadral Pod Shape) with porosity of 50%, 60%, 70% were proposed and the reinforcement structure was suggested for efficient strength reinforcement and the stiffness of each model was evaluated. As a result, the stiffness was reduced by 69~93% compared with Ti6Al4V ELI material, and the stiffness most similar to cortical bone is calculated with the deviation of about 12% in the BD model with 60% porosity. In this study, the interbody fusion cage made of Ti6Al4V ELI material with stiffness similar to cortical bone was implementing by applying cellular structure. Through this, it is considered that the limitation of the metal biomaterial by the high elastic modulus may be alleviated.

키워드

참고문헌

  1. Thomas J. Errico MD. Lumbar Disc Arthroplasty. Clinical Orthopaedics and Related Research. 2005;435:106-17. https://doi.org/10.1097/00003086-200506000-00016
  2. Richard F Frisch, Ingrid Y Luna and Gita Joshua. Static versus Expandable Interbody Spacers: Preliminary 1-Year Clinical and Radiographic Results. Journal of Clinical Neurology, NeuroSurgery and Spine. 2017;1(1):113.
  3. Vincent A. Stadelmann, Alexandre Terrier, Dominique P. Pioletti. Microstimulation at the bone-implant interface upregulates osteoclast activation pathways. Bone. 2008;42(2):358-64. https://doi.org/10.1016/j.bone.2007.09.055
  4. Prashanth J, Rao MS, Matthew H, Pelletier, PhD, William R, Walsh, PhD, Ralph J, Mobbs, MS, FRACS. Spine Interbody Implants: Material Selection and Modification, Functionalization and Bioactivation of Surfaces to Improve Osseointegration. Orthopaedic Surgery. 2014;6:81-89. https://doi.org/10.1111/os.12098
  5. Chi-Chien Niu, MD, Jen-Chung Liao, MD, Wen-Jer Chen, MD, Lih-Huei Chem, MD. Outcomes of Interbody Fusion Cages Used in 1 and 2-levels Anterior Cervical Discectomy and Fusion: Titanium Cages Versus Polyetheretherketone (PEEK) Cages. Journal of Spinal Disorders & Techniques. 2010;23(5):310-16. https://doi.org/10.1097/BSD.0b013e3181af3a84
  6. Adalberto Luiz ROSA, Marcio Mateus BELOTI. Effect of cp Ti Surface Roughness on Human Bone Marrow Cell Attachment, Proliferation, and Differentiation. Brazilian Dental Journal. 2003;14(1):16-21. https://doi.org/10.1590/S0103-64402003000100003
  7. S. Ramakrishna, J. Mayer, E. Wintermantel, Kam W. Leong. Biomedical applications of polymer-composite materials: a review. Composites Science and Technology. 2001;61(9):1189-224. https://doi.org/10.1016/S0266-3538(00)00241-4
  8. Ely L. Steinberg, Ehud Rath, Amir Shlaifer, Ofir Chechik, Eran Maman, Moshe Salai. Carbon fiber reinforced PEEK Optima-A composite material biomechanical properties and wear/debris characteristics of CF-PEEK composites for orthopedic trauma implants. Journal of the Mechanical Behavior of Biomedical Materials. 2013;17:221-8. https://doi.org/10.1016/j.jmbbm.2012.09.013
  9. Byung Jo Victor Yoon MS, Fred Xavier MD, PhD, Brendon R, Walker BS, Samuel Grinberg BA, Frank P, Cammisa MD, Celeste Abjornson, PhD. Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on polyetheretherketone. The Spine Journal. 2016;16:1238-43. https://doi.org/10.1016/j.spinee.2016.05.017
  10. David R, Carlile David C, Leach D. Roy Moore, and Nabil Zahlan. Mechanical Properties of the Carbon Fiber/PEEK Composite APC-2/AS-4 for Structural Applications, Advances in Thermoplastic Matrix Composite Materials, ASTM STP 1044. G. M. Newaz, Ed. American Society for Testing and Materials. 1989:199-212.
  11. Sajad Arabnejad R, Burnett Johnsto, Jenny Ann Pura, Baljinder Singh, Michael Tanzer, Damiano Pasini. High-strength porous biomaterials for bone replacement: A Strategy to assess the interplay between cell morphology, mechanical properties, bone ingrowth and manufacturing constraints. Acta Biomaterialia. 2016;30:345-56. https://doi.org/10.1016/j.actbio.2015.10.048
  12. Jayanthi Parthasarathy, Binil Starly, Shivakumar Raman, Andy Christensen. Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM). Journal of the Mechanical Behavior of Biomedical Materials. 2010;3(3):249-59. https://doi.org/10.1016/j.jmbbm.2009.10.006
  13. Amin Yavari S., Ahmadi SM, Wauthle R, Pouran B, Schrooten J, Weinans H, Zadpoor, AA. Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials. Journal of the Mechanical Behavior of Biomedical Materials. 2015;43:91-100. https://doi.org/10.1016/j.jmbbm.2014.12.015
  14. Donald T. Reilly, Albert H. Burstein. The elastic and ultimate properties of compact bone tissue, Journal of Biomechanics. 1975;8(6):393-6. https://doi.org/10.1016/0021-9290(75)90075-5
  15. Dennis R, Carter PhD, Dan M, Spengler MD. Mechanical properties and composition of cortical bone. Clinical Orthopaedics and Related Research. 1978;135:195-217.
  16. ASTM F136 Standard Specification for Wrought Titanium-6Aluminium-4Vanadium ELI(Extra Low Interstitial) Alloy for Surgical Implant Applications.
  17. Han Paul, Jang YW, Yoo OS, Kim JS, Kim HS, Lim DH. Evaluation of Biomechanical Stability of Newly Developed Revision Total Knee Arthroplasty through Strain and Stress Distribution Analysis within the Tibia: Finite Element Analysis. Journal of Biomedical Engineering Research. 2013;34(1):14-23. https://doi.org/10.9718/JBER.2013.34.1.14
  18. Ola LA, Harrysson, Omer Cansizoglu, Denis J, Marcellin-Little, Denis R, Cormier, Harvey A. West II. Direct metal fabrication of titanium implants with tailored materials and mechanical properties using electron beam melting technology. Materials Science and Engineering C. 2008;28:366-73. https://doi.org/10.1016/j.msec.2007.04.022
  19. ISO13314 Mechanical testing of metals-Ductility testing-Compression test for porous and cellular metals. 2011.
  20. Rae PJ, Brown EN, Orler, EB. The mechanical properties of poly(ether-ether-ketone) (PEEK) with emphasis on the large compressive strain response. Polymer. 2007;48(2):598-615. https://doi.org/10.1016/j.polymer.2006.11.032
  21. Steven M. Kurtz, John N. Devine. PEEK biomaterials in trauma, orthopedic, and spinal implants. Biomaterials. 2007;28:4845-69. https://doi.org/10.1016/j.biomaterials.2007.07.013
  22. ASTM F2077-11 Test Methods For Intervertebral Body Fusion Device.