Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
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Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet

  • Yoon, Nal Ae (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Park, Juyeong (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Jeong, Joo Yeon (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Rashidova, Nilufar (Tashkent Medical Academy) ;
  • Ryu, Jinhyun (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Roh, Gu Seob (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Kim, Hyun Joon (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Cho, Gyeong Jae (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Choi, Wan Sung (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Lee, Dong Hoon (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University) ;
  • Kang, Sang Soo (Dept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University)
  • Received : 2019.04.27
  • Accepted : 2019.05.18
  • Published : 2019.06.30
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Abstract

In many cases, obesity is associated with metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. Bitter melon has received attention as a diabetes treatment. $NAD^+$-dependent deacetylase (Sirtuin 1, SIRT1) has emerged as a novel therapeutic target for metabolic diseases. In this study, ethanol extract of bitter melon (BME) suppressed adipocyte differentiation and significantly increased the expression of SIRT1 in fully differentiated 3T3-L1 cells. Moreover, it enhanced the activation of AMP-activated protein kinase (AMPK). In high-fat diet (HFD)-fed induced-obesity mice, BME suppressed HFD-induced increases in body weight and white adipose tissue (WAT) weight. BME also increased the expression of SIRT1 and suppressed peroxisome proliferator-activated receptor and sterol regulatory element binding protein 1 expressions of WAT from HFD-fed mice. These findings suggest that BME prevents obesity by activating the SIRT1 and AMPK pathway and that it may be a useful dietary supplement for preventing obesity.

Keywords

References

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