Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin

  • Park, Kyo-Hyun (Department of Public Health, Keimyung University) ;
  • Kim, JiYeon (Department of Public Health, Keimyung University) ;
  • Jung, Suryun (Department of Public Health, Keimyung University) ;
  • Sung, Kyung-hwa (Environmental Health Services Center, Daegu Catholic University) ;
  • Son, Yeon-Kyoung (R&D Team, Food & Supplement Health Claims) ;
  • Bae, Jung Min (Department of Technical Assistance, Agency for Korea National Food Cluster (AnFC)) ;
  • Kim, Bae-Hwan (Department of Public Health, Keimyung University)
  • Received : 2019.03.04
  • Accepted : 2019.04.25
  • Published : 2019.10.15
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Abstract

The purpose of this study was to investigate the effect of $7-MEGA^{TM}$ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, $7-MEGA^{TM}$ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with $7-MEGA^{TM}$ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by $7-MEGA^{TM}$ 500. Therefore, the intake of $7-MEGA^{TM}$ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.

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References

  1. Kim, H.H., Cho, S., Lee, S., Kim, K.H., Cho, K.H., Eun, H.C. and Chung, J.H. (2006) Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. J. Lipid Res., 47, 921-930. https://doi.org/10.1194/jlr.M500420-JLR200
  2. Kim, H.H., Lee, M.J., Lee, S.R., Kim, K.H., Cho, K.H., Eun, H.C. and Chung, J.H. (2005) Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice. Mech. Ageing Dev., 126, 1170-1177. https://doi.org/10.1016/j.mad.2005.06.003
  3. Storey, A., McArdle, F., Friedmann, P.S., Jackson, M.J. and Rhodes, L.E. (2005) Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. J. Invest. Dermatol., 124, 248-255. https://doi.org/10.1111/j.0022-202X.2004.23543.x
  4. Jo, W.S., Yang, K.M., Park, H.S., Kim, G.Y., Nam, B.H., Jeong, M.H. and Choi, Y.J. (2012) Effect of microalgal extracts of tetraselmissuecica against UVB-induced photoaging in human skin fibroblast. Toxicol. Res., 28, 241-248. https://doi.org/10.5487/TR.2012.28.4.241
  5. Otton, R., Marin, D.P., Bolin, A.P., Macedo, R.D.C.S., Campoio, T.R., Fineto, C., Jr., Guerra, B.A., Leite, J.R., Barros, M.P. and Mattei, R. (2012) Combined fish oil and astaxanthin supplementation modulates rat lymphocyte function. Eur. J. Nutr., 51, 707-718. https://doi.org/10.1007/s00394-011-0250-z
  6. Calder, P.C. (2008) Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol. Nutr. Food Res., 52, 885-897. https://doi.org/10.1002/mnfr.200700289
  7. Bazan, N.G. (2007) Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr. Opin. Clin. Nutr. Metab. Care, 10, 136-141. https://doi.org/10.1097/MCO.0b013e32802b7030
  8. Park, J.M., Kwon, S.H., Han, Y.M., Hahm, K.B. and Kim, E.H. (2013) Omega-3 polyunsaturated Fatty acids as potential chemopreventive agent for gastrointestinal cancer. J. Cancer Prev., 18, 201-208. https://doi.org/10.15430/JCP.2013.18.3.201
  9. Whigham, L.D., Watras, A.C. and Schoeller, D.A. (2007) Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am. J. Clin. Nutr., 85, 1203-1211. https://doi.org/10.1093/ajcn/85.5.1203
  10. Finucane, O.M., Lyons, C.L., Murphy, A.M., Reynolds, C.M., Klinger, R., Healy, N.P., Cooke, A.A., Coll, R.C., McAllan, L., Nilaweera, K.N., O'Reilly, M.E., Tierney, A.C., Morine, M.J., Alcala-Diaz, J.F., Lopez-Miranda, J., O'Connor, D.P., O'Neill, L.A., McGillicuddy, F.C. and Roche, H.M. (2015) Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-$1{\beta}$ secretion and insulin resistance despite obesity. Diabetes, 64, 2116-2128. https://doi.org/10.2337/db14-1098
  11. Nicolai, E., Sinibaldi, F., Sannino, G., Lagana, G., Basoli, F., Licoccia, S., Cozza, P., Santucci, R. and Piro, M.C. (2017) Omega-3 and Omega-6 fatty acids act as inhibitors of the matrix metalloproteinase-2 and matrix metalloproteinase-9 activity. Protein J., 36, 278-285. https://doi.org/10.1007/s10930-017-9727-9
  12. Zielinska, A. and Nowak, I. (2017) Abundance of active ingredients in sea-buckthorn oil. Lipids Health Dis., 16, 95. https://doi.org/10.1186/s12944-017-0469-7
  13. Maguire, L.S., O'Sullivan, S.M., Galvin, K., O'Connor, T.P. and O'Brien, N.M. (2004) Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. Int. J. Food Sci. Nutr., 55, 171-178. https://doi.org/10.1080/09637480410001725175
  14. Song, I.B., Gu, H., Han, H.J., Lee, N.Y., Cha, J.Y., Son, Y.K. and Kwon, J. (2018) Effects of 7-$MEGA^{TM}$ 500 on oxidative stress, inflammation, and skin regeneration in $H_2O_2$-treated skin cells. Toxicol. Res., 34, 103-110. https://doi.org/10.5487/TR.2018.34.2.103
  15. Moon, H.J., Lee, S.R., Shim, S.N., Jeong, S.H., Stonik, V.A., Rasskazov, V.A., Zvyagintseva, T. and Lee, Y.H. (2008) Fucoidan inhibits UVB-induced MMP-1 expression in human skin fibroblasts. Biol. Pharm. Bull., 31, 284-289. https://doi.org/10.1248/bpb.31.284
  16. Sirerol, J.A., Feddi, F., Mena, S., Rodriguez, M.L., Sirera, P., Aupi, M., Perez, S., Asensi, M., Ortega, A. and Estrela, J.M. (2015) Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis. Free Radic. Biol. Med., 85, 1-11. https://doi.org/10.1016/j.freeradbiomed.2015.03.027
  17. Saw, C.L., Huang, M.T., Liu, Y., Khor, T.O., Conney, A.H. and Kong, A.N. (2011) Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol. Carcinog., 50, 479-486. https://doi.org/10.1002/mc.20725
  18. Huang, M.T. (2006) Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears. Mol. Nutr. Food Res., 50, 115-122. https://doi.org/10.1002/mnfr.200500101
  19. Jin, X.J., Kim, E.J., Oh, I.K., Kim, Y.K., Park, C.H. and Chung, J.H. (2010) Prevention of UV-induced skin damages by 11,14,17- eicosatrienoic acid in hairless mice in vivo. J. Korean Med. Sci., 25, 930-937. https://doi.org/10.3346/jkms.2010.25.6.930
  20. Bueno-Hernandez, N., Sixtos-Alonso, M.S., MilkeGarcia, M.D.P. and Yamamoto-Furusho, J.K. (2017) Effect of Cispalmitoleic acid supplementation on inflammation and expression of $HNF4{\gamma}$, $HNF4{\alpha}$ and IL6 in patients with ulcerative colitis. Minerva Gastroenterol. Dietol., 63, 257-263.
  21. Hunt, D.P., Jaholda, C. and Chandran, S. (2009) Multipotent skin-derived precursors: from biology to clinical translation. Curr. Opin. Biotechnol., 20, 522-530. https://doi.org/10.1016/j.copbio.2009.10.004
  22. Quan, T.H., Qin, Z.P., Xu, Y.R., He, T., Kang, S., Voorhees, J.J. and Fisher, G.J. (2010) Ultraviolet irradiation induces CYR61/CCN1, a mediator of collagen homeostasis, through activation of transcription factor AP-1 in human skin fibroblasts. J. Invest. Dermatol., 130, 1697-1706. https://doi.org/10.1038/jid.2010.29
  23. Guo, B.R., Liu, P. and Ma, C.C. (2009) The expression of c-jun, c-fos in light aging disease and significance. Chin. Skin Venereol. Mag., 23, 791-793.