ALGAE

The Korean Society of Phycology (한국조류학회(藻類))
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Ecklonia cava (Laminariales) and Sargassum horneri (Fucales) synergistically inhibit the lipopolysaccharide-induced inflammation via blocking NF-κB and MAPK pathways

  • Asanka Sanjeewa, K.K. (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University) ;
  • Fernando, I.P.S. (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University) ;
  • Kim, Seo-Young (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University) ;
  • Kim, Won-Suck (College of Medical and Life Sciences, Silla University) ;
  • Ahn, Ginnae (Department of Marine Bio Food Science, Chonnam National University) ;
  • Jee, Youngheun (Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Jeon, You-Jin (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University)
  • Received : 2018.09.13
  • Accepted : 2019.02.10
  • Published : 2019.03.15
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Abstract

Ecklonia cava (EC) has been widely utilized as an ingredient in commercial products such as functional foods and cosmeceuticals. Recently it has been found that Sargassum horneri (SH) has been invading on Jeju Island coast area by its huge blooming. Moreover, both seaweeds are considering as important ingredients in traditional medicine specifically in East-Asian countries (China, Japan, and Korea). In the present study, we attempted to compare anti-inflammatory properties of 70% ethanolic extracts of EC (ECE), SH (SHE), and their different combinations on lipopolysaccharide (LPS)-activated RAW 264.7 cells. Results indicated that 8 : 2 combinations of ECE : SHE significantly inhibited LPS-activated inflammatory responses (cytokines, protein, and gene expression) in RAW 264.7 macrophage cells compared to the respective extracts and other combinations. The synergistic effect of ECE and SHE was found to be prominent than the effects of ECE or SHE alone. These observations provide useful information for the industrial formulation of functional materials (functional foods and cosmeceuticals) using these two particular seaweeds in Jeju Island of South Korea.

Keywords

Acknowledgement

Supported by : Jeju National University

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