Clinical and Experimental Reproductive Medicine

  • 제46권3호
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  • Pages.99-106
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  • 2019
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Understanding the molecular mechanisms of bisphenol A action in spermatozoa

  • Rahman, Md Saidur (Department of Animal Science and Technology and BET Research Institute, Chung-Ang University) ;
  • Pang, Myung-Geol (Department of Animal Science and Technology and BET Research Institute, Chung-Ang University)
  • 투고 : 2019.05.13
  • 심사 : 2019.07.25
  • 발행 : 2019.09.30
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초록

Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.

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과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

참고문헌

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피인용 문헌

  1. Bisphenols Threaten Male Reproductive Health via Testicular Cells vol.11, 2019, https://doi.org/10.3389/fendo.2020.00624
  2. The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword vol.9, pp.2, 2019, https://doi.org/10.3390/antiox9020111
  3. Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction vol.9, pp.5, 2020, https://doi.org/10.3390/antiox9050405
  4. Multigenerational and transgenerational impact of paternal bisphenol A exposure on male fertility in a mouse model vol.35, pp.8, 2019, https://doi.org/10.1093/humrep/deaa139
  5. Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality vol.10, pp.1, 2019, https://doi.org/10.3390/antiox10010092
  6. Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction vol.10, pp.6, 2019, https://doi.org/10.3390/antiox10060837
  7. Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review vol.9, pp.11, 2019, https://doi.org/10.3390/biomedicines9111744