Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Anti-inflammatory and Wrinkle Improvement Effects of Peptides from Ginseng Berry Amino Acidic Complex

진생베리 아미노산 복합체로부터 분리한 펩타이드의 항염, 주름개선 효과

  • Kang, Sang Moon (R&D Center, ANPEP Inc.) ;
  • Park, Chung (Department of Life Science, Hyehwa Liberal Arts College, Daejeon University)
  • 강상문 (에이앤펩(주) 기술연구소) ;
  • 박청 (대전대학교 생명과학부)
  • Received : 2019.08.30
  • Accepted : 2019.09.27
  • Published : 2019.09.30
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Abstract

Ginseng berry (GB) contains Ginsenoside Re and has anti-inflammatory and anti-wrinkle properties. In this study, TLC fractions 1, 2, and 4 of the ginseng berry amino acid complex were identified and analyzed by HPLC. And identified a peptide (AP-1) by LC/MASS analysis of fraction 1. The anti-inflammatory activity was confirmed by investigating the inhibitory effect of AP-1 on NO production. In addition, collagen synthesis using procollagen type I C-peptide (PIP) ELISA kit was 50% higher effective than that of the control group. From these results, the peptide isolated from ginseng berry amino acid complex is considered to have anti-inflammatory and anti-wrinkle effect, and may be useful as an anti-inflammatory and anti-aging cosmetic raw material.

Ginseng berry(GB)는 진세노사이드Re를 함유하고 있으며, 항염, 피부 주름 완화의 기능을 가지고 있다. 본 연구에서는 Ginseng berry 아미노산 복합체의 TLC 분획 fraction 1, 2, 4를 확인하고 HPLC로 분석하였으며, fraction 1의 LC/MASS 분석을 통해 peptide (AP-1)를 동정하였다. AP-1에 의한 NO 생성 억제 효과를 조사하여 항염증 활성을 확인하였다. 또한 procollagen type I C-peptide (PIP) ELISA kit를 이용한 collagen 합성은 대조군 대비 50% 이상의 효과를 보였다. 이상의 결과로부터 진생베리 아미노산 복합체로부터 분리한 펩타이드는 항염과 주름개선 효능을 가진다고 사료되며, 향후 항염 및 항노화 화장품 원료로서의 이용 가능성을 보였다.

Keywords

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