Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia

  • Manoppo, Jeanette (Division of Gastroentero-hepatology, Department of Pediatrics, Sam Ratulangi University/Prof. Dr. R.D. Kandou Hospital Manado) ;
  • Tasiringan, Hilda (Department of Pediatrics, Sam Ratulangi University/Prof. Dr. R.D. Kandou Hospital Manado) ;
  • Wahani, Audrey (Division of Respirology, Department of Pediatrics, Sam Ratulangi University/Prof. Dr. R.D. Kandou Hospital Manado) ;
  • Umboh, Adrian (Division of Nephrology, Department of Pediatrics, Sam Ratulangi University/Prof. Dr. R.D. Kandou Hospital Manado) ;
  • Mantik, Max (Division of Hemato-Oncology, Department of Pediatrics, Sam Ratulangi University/Prof. Dr. R.D. Kandou Hospital Manado)
  • Received : 2018.09.07
  • Accepted : 2019.01.24
  • Published : 2019.05.15
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Abstract

Purpose: To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA). Methods: We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels <27.8 pg/L. Results: A total of 66 children were randomized into 2 groups. Thirty-four children received iron preparations with the addition of L. reuteri DSM 17938 (group 1), whereas the other 32 received iron preparations alone (group 2). The baseline Ret-He levels before intervention were similar in both groups. After 14 days of intervention, mean Ret-He level in group 1 changed from $24.43{\pm}1.64$ to $28.21{\pm}1.72pg/L$ (P=0.000). Mean Ret-He level in group 2 changed from $24.31{\pm}1.42$ to $27.03{\pm}2.14pg/L$ (P=0.000). Statistical analysis showed a significant increase in Ret-He levels in both groups; Ret-He levels were significantly higher in the experimental group than in the control group (P<0.05). Conclusion: Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.

Keywords

References

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