Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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The association between preeclampsia and autism spectrum disorders among children: a meta-analysis

  • Jenabi, Ensiyeh (Pediatric Developmental Disorders Research Center, Hamadan University of Medical Sciences) ;
  • Karami, Manoochehr (Research Center for Health Sciences, Hamadan University of Medical Sciences) ;
  • Khazaei, Salman (Research Center for Health Sciences, Hamadan University of Medical Sciences) ;
  • Bashirian, Saeid (Social Determinants of Health Research Center, Hamadan University of Medical Sciences)
  • Received : 2018.09.03
  • Accepted : 2018.12.20
  • Published : 2019.04.15
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Abstract

Purpose: In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children. Methods: A search for relevant studies in major databases, including Web of Science, PubMed, and Scopus, was performed up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among studies. Results: The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD [(OR, 1.36; 95% CI, 1.12-1.60) and (RR, 1.30; 95% CI, 1.20-1.41)]. Conclusions: Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.

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References

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