Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Alcohol consumption and gastric cancer risk in Korea: a case-control study

  • Kim, Mi Hui (Department of Food and Nutrition, Gangneung-Wonju National University College of Life Science) ;
  • Kim, Shin Ah (Department of Food and Nutrition, Gangneung-Wonju National University College of Life Science) ;
  • Park, Chan Hyuk (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Eun, Chang Soo (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Han, Dong Soo (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Yong Sung (Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Song, Kyu Sang (Department of Pathology, Chungnam National University College of Medicine) ;
  • Choi, Bo Youl (Department of Preventive Medicine, Hanyang University College of Medicine) ;
  • Kim, Hyun Ja (Department of Food and Nutrition, Gangneung-Wonju National University College of Life Science)
  • Received : 2019.05.22
  • Accepted : 2019.08.22
  • Published : 2019.10.01
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Abstract

BACKGROUND/OBJECTIVES: The International Agency for Research on Cancer defined alcohol beverages and acetaldehyde derived from alcoholic beverages as a Group 1 carcinogen to humans. However, the association between alcohol consumption and gastric cancer risk has been controversial in Korean. We assessed the relationship between alcohol consumption and gastric cancer risk in Korea through a case-control study. SUBJECTS/METHODS: From 2 hospitals, a total of 316 cases with gastric cancer (208 men, 108 women) were selected and matched to 316 controls by sex and age (${\pm}5years$) during the same duration. The current status, frequency, and amount of alcohol consumption for a year three years ago were assessed by trained interviewers. RESULTS: Alcohol consumption status and frequency did not show any significant association with gastric cancer risk. However, high alcohol consumption (${\geq}20g/day$ for women or ${\geq}40g/day$ for men) significantly increased the risk of gastric cancer (odds ratio (OR) 1.73; 95% confidence interval (CI) 1.05-2.85). Gastric cancer risk was strongly positively associated with alcohol consumption of ${\geq}20g/day$, especially in women (OR 5.62; 95% CI 1.32-23.81). CONCLUSION: The results from this study suggest that excessive alcohol consumption rather than the current status or frequency of alcohol consumption contributes to the increased risk of gastric cancer, especially in women.

Keywords

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