Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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Relationship between Arterial Stiffness as Measured by the Cardio-Ankle Vascular Index with Body Mass Index in Healthy Elderly Subjects

건강한 노인에서 심장-발목 혈관지수로 측정한 동맥 경직도와 체질량 지수간의 상관관계

  • Shin, Kyung A (Department of Clinical Laboratory Science, Shinsung University)
  • Received : 2019.08.10
  • Accepted : 2019.09.03
  • Published : 2019.09.30
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Abstract

An inverse correlation between obesity and arterial stiffness has been reported, but there are no consistent results in elderly subjects. This study examined the relationship between the arterial stiffness measured by the CAVI (cardio-ankle vascular index) and BMI (body mass index) in healthy elderly people. This study included 629 healthy elderly people aged 65 and over who underwent health examinations at a general hospital in Gyeonggi from July 2018 to June 2019. Metabolic syndrome was diagnosed using the criteria of the Adult Treatment Panel (ATP) III of the US National Cholesterol Education Program (NCEP). Among the criteria of NCEP-ATP III, the waist circumference and obesity criteria were based on the WHO criteria. All subjects underwent a biochemical blood test and an assessment of the CAVI. In both men and women, the CAVI was lower in the obese group than in the normal weight group. Gender (P=0.047), age (P<0.001), BMI (P<0.001), and waist circumference (P=0.008) were factors affecting the CAVI. Gender, high blood pressure, and hyperglycemia were independent positive predictors of the CAVI levels, while obesity was a negative predictor. Therefore, the CAVI and BMI showed an inverse correlation. In conclusion, there was an inverse correlation between the CAVI and BMI in the elderly, and obesity was a negative predictor of the CAVI.

비만과 혈관 경직도간에 역상관 관계가 보고되고 있으나, 고령자나 노인에서는 일관된 결과를 보이고 있지 않다. 이 연구에서는 건강한 노인을 대상으로 CAVI로 측정한 동맥 경직도와 BMI간의 연관성을 조사하였다. 이 연구는 2018년 7월부터 2019년 6월까지 경기지역 종합병원에서 건강검진을 시행한 65세 이상 건강한 노인을 629명을 대상으로 하였다. 대사증후군 진단은 US National Cholesterol Education Program(NCEP)의 Adult Treatment Panel (ATP) III의 기준에 따랐으며, NCEP-ATP III의 기준 중 허리둘레 및 비만기준은 WHO의 기준에 따랐다. 모든 연구 대상자는 생화학적 혈액검사 및 CAVI를 측정하였다. 남녀 모두에서 CAVI치는 정상체중군보다 비만군에서 낮았으며, 성별(P=0.047), 연령(P<0.001), BMI (P<0.001), 허리둘레(P=0.009)는 CAVI에 영향을 미치는 요인이었다. 또한 성별, 높은 혈압, 고혈당은 CAVI치의 독립적인 정적 예측인자이지만, 비만은 부적 예측인자로 나타나 CAVI와 BMI는 역상관 관계를 보였다. 결론적으로, 이 연구는 노인을 대상으로 CAVI와 BMI간에 역상관 관계를 나타내며, BMI로 측정한 비만은 CAVI의 부적 예측인자였다.

Keywords

References

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