Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis

  • Jenabi, Ensiyeh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences) ;
  • Bashirian, Saied (Social Determinants of Health Research Center, Hamadan University of Medical Sciences) ;
  • Khazaei, Salman (Research Center for Health Sciences, Hamadan University of Medical Sciences) ;
  • Basiri, Zohreh (Science Epidemiology, Faculty of Science, University of Melbourne)
  • 투고 : 2019.02.20
  • 심사 : 2019.05.17
  • 발행 : 2019.10.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Attention deficit hyperactivity disorder (ADHD) symptoms have a major impact on individuals, families, and society. Therefore identification risk factors of ADHD are a public health priority. Purpose: This is meta-analysis evaluated the association between maternal prepregnancy body mass index and the risk of ADHD among the resulting offspring. Methods: The search identified studies published through December 2018 in the PubMed, Web of Science, and Scopus databases. The odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CI) extracted from eligible studies were used as the common measure of association among studies. Results: A significant association was found between overweight women and the risk of ADHD among children with the pooled HR and OR estimates (HR, 1.27 and 95% CI, 1.17-1.37; OR, 1.28 and 95% CI, 1.15-1.40, respectively). This association was significant between obese women and the risk of ADHD among children and adolescents with the pooled estimates of HR and OR (HR, 1.65 and 95% CI, 1.55-1.76; OR, 1.42 and 95% CI, 1.23-1.61). Conclusion: The current epidemiological studies present sufficient evidence that prepregnancy overweight and obesity are significantly associated with an increased risk of ADHD among children and adolescents. These findings provide a new approach to preventing ADHD by controlling weight gain in the prenatal period, which should be considered by policymakers.

키워드

참고문헌

  1. Adesman AR. The diagnosis and management of attention-deficit/hyperactivity disorder in pediatric patients. Prim Care Companion J Clin Psychiatry 2001;3:66-77. https://doi.org/10.4088/PCC.v03n0204
  2. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 2007;164:942-8. https://doi.org/10.1176/appi.ajp.164.6.942
  3. Sciberras E, Mulraney M, Silva D, Coghill D. Prenatal risk factors and the etiology of ADHD-review of existing evidence. Curr Psychiatry Rep 2017;19:1. https://doi.org/10.1007/s11920-017-0753-2
  4. Plomp E, Van Engeland H, Durston S. Understanding genes, environment and their interaction in attention-deficit hyperactivity disorder: is there a role for neuroimaging? Neuroscience 2009;164:230-40. https://doi.org/10.1016/j.neuroscience.2009.07.024
  5. Nigg J, Nikolas M, Burt SA. Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2010;49:863-73. https://doi.org/10.1016/j.jaac.2010.01.025
  6. Thapar A, Cooper M, Eyre O, Langley K. What have we learnt about the causes of ADHD? J Child Psychol Psychiatry 2013;54:3-16. https://doi.org/10.1111/j.1469-7610.2012.02611.x
  7. Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry 2003;160:1028-40. https://doi.org/10.1176/appi.ajp.160.6.1028
  8. Van Lieshout RJ, Taylor VH, Boyle MH. Pre-pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review. Obes Rev 2011;12:e548-59. https://doi.org/10.1111/j.1467-789X.2010.00850.x
  9. Rodriguez A, Miettunen J, Henriksen TB, Olsen J, Obel C, Taanila A, et al. Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int J Obes (Lond) 2008;32:550-7. https://doi.org/10.1038/sj.ijo.0803741
  10. Rodriguez A. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatry 2010;51:134-43. https://doi.org/10.1111/j.1469-7610.2009.02133.x
  11. Rosenberg TJ, Garbers S, Lipkind H, Chiasson MA. Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes: differences among 4 racial/ethnic groups. Am J Public Health 2005;95: 1545-51. https://doi.org/10.2105/AJPH.2005.065680
  12. Peters JP, Hooft L, Grolman W, Stegeman I. Reporting quality of systematic reviews and meta-analyses of otorhinolaryngologic articles based on the PRISMA statement. PLoS One. 2015;10:e0136540. https://doi.org/10.1371/journal.pone.0136540
  13. World Health Organization. WHO global database on body mass index. Geneva (Switzerland): World Health Organization; 2014.
  14. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Internet]. Ottawa (ON): Ottawa Hospital Research Institute; 2009 [cited 2017 Sep 15]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
  15. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34. https://doi.org/10.1136/bmj.315.7109.629
  16. Chen Q, Sjolander A, Langstrom N, Rodriguez A, Serlachius E, D'Onofrio BM, et al. Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design. Int J Epidemiol 2014;43:83-90. https://doi.org/10.1093/ije/dyt152
  17. Kong L, Norstedt G, Schalling M, Gissler M, Lavebratt C. The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes. Pediatrics 2018;142(3) [Epub]. pii: e20180776. https://doi.org/10.1542/peds.2018-0776.
  18. Mikkelsen SH, Hohwu L, Olsen J, Bech BH, Liew Z, Obel C. Parental body mass index and behavioral problems in their offspring: a Danish National Birth Cohort Study. Am J Epidemiol 2017;186:593-602. https://doi.org/10.1093/aje/kwx063
  19. van der Burg JW, Jensen ET, van de Bor M, Joseph RM, O'Shea TM, Kuban K, et al. Maternal obesity and attention-related symptoms in the preterm offspring. Early Hum Dev 2017;115:9-15. https://doi.org/10.1016/j.earlhumdev.2017.08.002
  20. Andersen CH, Thomsen PH, Nohr EA, Lemcke S. Maternal body mass index before pregnancy as a risk factor for ADHD and autism in children. Eur Child Adolesc Psychiatry 2018;27:139-48. https://doi.org/10.1007/s00787-017-1027-6
  21. Jo H, Schieve LA, Sharma AJ, Hinkle SN, Li R, Lind JN. Maternal prepregnancy body mass index and child psychosocial development at 6 years of age. Pediatrics 2015;135:e1198-209. https://doi.org/10.1542/peds.2014-3058
  22. Buss C, Entringer S, Davis EP, Hobel CJ, Swanson JM, Wadhwa PD, et al. Impaired executive function mediates the association between maternal pre-pregnancy body mass index and child ADHD symptoms. PLoS One 2012;7:e37758. https://doi.org/10.1371/journal.pone.0037758
  23. Li M, Fallin MD, Riley A, Landa R, Walker SO, Silverstein M, et al. The association of maternal obesity and diabetes with autism and other developmental disabilities. Pediatrics 2016;137:e20152206. https://doi.org/10.1542/peds.2015-2206
  24. Valleau JC, Sullivan EL. The impact of leptin on perinatal development and psychopathology. J Chem Neuroanat 2014;61-62:221-32. https://doi.org/10.1016/j.jchemneu.2014.05.001
  25. Short SJ, Lubach GR, Karasin AI, Olsen CW, Styner M, Knickmeyer RC, et al. Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey. Biol Psychiatry 2010;67:965-73. https://doi.org/10.1016/j.biopsych.2009.11.026
  26. Willette AA, Lubach GR, Knickmeyer RC, Short SJ, Styner M, Gilmore JH, et al. Brain enlargement and increased behavioral and cytokine reactivity in infant monkeys following acute prenatal endotoxemia. Behav Brain Res 2011;219:108-15. https://doi.org/10.1016/j.bbr.2010.12.023
  27. Sullivan EL, Nousen EK, Chamlou KA. Maternal high fat diet consumption during the perinatal period programs offspring behavior. Physiol Behav 2014;123:236-42. https://doi.org/10.1016/j.physbeh.2012.07.014
  28. Kang SS, Kurti A, Fair DA, Fryer JD. Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring. J Neuroinflammation 2014;11:156. https://doi.org/10.1186/s12974-014-0156-9
  29. Sanchez CE, Barry C, Sabhlok A, Russell K, Majors A, Kollins SH, et al. Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis. Obes Rev 2018;19:464-84. https://doi.org/10.1111/obr.12643

피인용 문헌

  1. Maternal pre-pregnancy overweight/obesity and the risk of attention-deficit/hyperactivity disorder in offspring: a systematic review, meta-analysis and quasi-experimental family-based study vol.49, pp.3, 2019, https://doi.org/10.1093/ije/dyaa040
  2. Understanding the Link Between Maternal Overnutrition, Cardio-Metabolic Dysfunction and Cognitive Aging vol.15, 2021, https://doi.org/10.3389/fnins.2021.645569
  3. Maternal immune activation and neuroinflammation in human neurodevelopmental disorders vol.17, pp.9, 2019, https://doi.org/10.1038/s41582-021-00530-8
  4. Is there an association between labor induction and attention-deficit/hyperactivity disorder among children? vol.64, pp.9, 2019, https://doi.org/10.3345/cep.2020.01557
  5. Association between humidifier disinfectant exposure during infancy and subsequent neuropsychiatric outcomes during childhood: a nation-wide cross-sectional study vol.21, pp.1, 2021, https://doi.org/10.1186/s12887-021-02825-7