DOI QR코드

DOI QR Code

Benefits of Angiotensin Receptor Blockade: Preventing Smooth Muscle Cell Senescence and Beyond

  • Song, Parkyong (Department of Convergence Medicine, Pusan National University School of Medicine) ;
  • Kim, Jae Ho (Department of Physiology, Pusan National University School of Medicine, Pusan National University)
  • 투고 : 2019.06.03
  • 심사 : 2019.06.05
  • 발행 : 2019.07.31

초록

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참고문헌

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  2. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007;8:729-40. https://doi.org/10.1038/nrm2233
  3. Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 1991;196:33-9. https://doi.org/10.1016/0014-4827(91)90453-2
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  5. Baker DJ, Perez-Terzic C, Jin F, et al. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol 2008;10:825-36. https://doi.org/10.1038/ncb1744
  6. Min LJ, Mogi M, Iwai M, Horiuchi M. Signaling mechanisms of angiotensin II in regulating vascular senescence. Ageing Res Rev 2009;8:113-21. https://doi.org/10.1016/j.arr.2008.12.002
  7. Min SH, Kim SH, Jeong IK, et al. Independent association of serum aldosterone level with metabolic syndrome and insulin resistance in Korean adults. Korean Circ J 2018;48:198-208. https://doi.org/10.4070/kcj.2017.0200
  8. Kim I, Park CS, Lee HY. Angiotensin II type 1 receptor blocker, fimasartan, reduces vascular smooth muscle cell senescence by inhibiting the CYR61 signaling pathway. Korean Circ J 2019;49:615-26. https://doi.org/10.4070/kcj.2018.0379
  9. Kunieda T, Minamino T, Nishi J, et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006;114:953-60. https://doi.org/10.1161/CIRCULATIONAHA.106.626606
  10. Welch WJ. Angiotensin II-dependent superoxide: effects on hypertension and vascular dysfunction. Hypertension 2008;52:51-6. https://doi.org/10.1161/HYPERTENSIONAHA.107.090472