Journal of the Korean Society of Manufacturing Process Engineers (한국기계가공학회지)

The Korean Society of Manufacturing Process Engineers (한국기계가공학회)
권호 표지
DOI QR코드

DOI QR Code

Measurement of Substance Diffusion on a Bio-body Surface Using Laser Plasma Spectroscopy

생체 표면에서의 물질 확산 측정을 위한 레이저 플라즈마 분광법 적용

  • Yoon, Sangwoo (Department of Mechanical & Automotive Engineering, Seoul National University of Science & Technology) ;
  • Oh, Jiheon (Department of Mechanical & Automotive Engineering, Seoul National University of Science & Technology) ;
  • Park, Seongyong (Department of Mechanical & Automotive Engineering, Seoul National University of Science & Technology) ;
  • Jung, Jaekyeong (Department of Mechanical & Automotive Engineering, Seoul National University of Science & Technology) ;
  • Kim, Joohan (Department of Mechanical & Automotive Engineering, Seoul National University of Science & Technology)
  • 윤상우 (서울과학기술대학교 기계.자동차공학과) ;
  • 오지헌 (서울과학기술대학교 기계.자동차공학과) ;
  • 박성용 (서울과학기술대학교 기계.자동차공학과) ;
  • 정재경 (서울과학기술대학교 기계.자동차공학과) ;
  • 김주한 (서울과학기술대학교 기계.자동차공학과)
  • Received : 2019.06.18
  • Accepted : 2019.07.01
  • Published : 2019.07.31
Download PDF
⟨ Previous Next ⟩

Abstract

The diffusion of the drug component of the inflammatory patch into the living tissue was analyzed by laser induced plasma spectroscopy (LIBS). Calcium element, which is a diffusion catalyst of the drug in the inflammatory analgesic patch, is transferred into the body through the diffusion process of the substance. The test pieces used in the experiment are pig skin tissues which are similar to human skin. As a result, the diffusion coefficient D of the calcium element was found to be average $8.24{\times}10^{-2}({\mu}m^2/s)$. Experimental results showed that the most influential factors on the diffusion of materials were temperature variables.

Keywords

References

  1. Wang, Y., Combe, C., Clark, M. M. "The effects of pH and calcium on the diffusion coefficient of humic acid", Journal of Membrane Science, Vol. 183, No. 1, pp.49-60, 2001. https://doi.org/10.1016/S0376-7388(00)00555-X
  2. Donahue, B. S., Abercrombie, R. F., "Free diffusion coefficient of ionic calcium in cytoplasm", Cell calcium, Vol. 8, No. 6, pp.437-448, 1987. https://doi.org/10.1016/0143-4160(87)90027-3
  3. Sanger, P., Deckwer, W. D., "Liquid-solid mass transfer in aerated suspensions", The Chemical Engineering Journal, Vol. 22, No. 3, pp.179-186, 1981. https://doi.org/10.1016/0300-9467(81)80013-5
  4. Kang, D., Kim, J., "Hardness Analysis of Surface Treated Magnesium Alloy using Laser Induced Breakdown Spectroscopy", Journal of the Korean Society of Manufacturing Technology Engineers, Vol. 24, No. 6, pp.625-631, 2015. https://doi.org/10.7735/ksmte.2015.24.6.625
  5. Yoon, S., Kim, J. H., Kim, J., "Measurement of Mass Transfer from Metal Friction Surfaces using Laser Plasma Spectroscopy", Journal of the Korean Society of Manufacturing Process Engineers, Vol. 16, No. 4, 46-52, 2017. https://doi.org/10.14775/ksmpe.2017.16.4.046
  6. Shin, H., Ahn, H. S., "Adhesive, Friction, and Deformation Behaviors of Pig Skin under Various Exposure Times to Air", Tribology and Lubricants, Vol. 30, No. 1, pp.36-45, 2014. https://doi.org/10.9725/kstle.2014.30.1.36