Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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Hypofractionated radiotherapy for early glottic cancer: a retrospective interim analysis of a single institution

  • Lee, Jeong Won (Department of Radiation Oncology, Catholic University of Daegu, School of Medicine) ;
  • Lee, Jeong Eun (Department of Radiation Oncology, School of Medicine, Kyungpook National University) ;
  • Park, Junhee (Department of Radiation Oncology, School of Medicine, Kyungpook National University) ;
  • Sohn, Jin Ho (Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University) ;
  • Ahn, Dongbin (Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University)
  • Received : 2019.03.04
  • Accepted : 2019.06.17
  • Published : 2019.06.30
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Abstract

Purpose: To evaluate the results of hypofractionated radiotherapy (HFX) for early glottic cancer. Materials and Methods: Eighty-five patients with cT1-2N0M0 squamous cell carcinoma of the glottis who had undergone HFX, performed using intensity-modulated radiotherapy (IMRT, n = 66) and three-dimensional conformal radiotherapy (3D CRT, n = 19) were analyzed. For all patients, radiotherapy was administered at 60.75 Gy in 27 fractions. Forty-three patients received a simultaneous integrated boost (SIB) of 2.3-2.5 Gy per tumor fraction. Results: The median follow-up duration was 29.9 months (range, 5.5 to 76.5 months). All patients achieved complete remission at a median of 50 days after the end of radiotherapy (range, 14 to 206 days). The 5-year rates for locoregional recurrence-free survival was 88.1%, and the 5-year overall survival rate was 86.2%. T2 stage was a prognostic factor for locoregional recurrence-free survival after radiotherapy (p = 0.002). SIB for the tumor did not affect disease control and survival (p = 0.191 and p = 0.387, respectively). No patients experienced acute or chronic toxicities of ≥grade 3. IMRT significantly decreased the dose administered to the carotid artery as opposed to 3D CRT (V35, p < 0.001; V50, p < 0.001). Conclusions: Patients treated with HFX achieved acceptable locoregional disease control rates and overall survival rates compared with previous HFX studies. A fraction size of 2.25 Gy provided good disease control regardless of SIB administration.

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References

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