Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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Retrospective analysis of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy of postoperative treatment for biliary tract cancer

  • Lee, Hyo Chun (Department of Radiation Oncology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jong Hoon (Department of Radiation Oncology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Sea-Won (Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Joo Hwan (Department of Radiation Oncology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Yu, Mina (Department of Radiation Oncology, Buchoen St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Jang, Hong Seok (Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Sung Hwan (Department of Radiation Oncology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea)
  • Received : 2019.07.22
  • Accepted : 2019.12.18
  • Published : 2019.12.31
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Abstract

Purpose: This study was conducted to compare the outcome of three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for the postoperative treatment of biliary tract cancer. Materials and Methods: From February 2008 to June 2016, 57 patients of biliary tract cancer treated with curative surgery followed by postoperative 3D-CRT (n = 27) or IMRT (n = 30) were retrospectively enrolled. Results: Median follow-up time was 23.6 months (range, 5.2 to 97.6 months) for all patients and 38.4 months (range, 27.0 to 89.2 months) for survivors. Two-year recurrence-free survival is higher in IMRT arm than 3D-CRT arm with a marginal significance (25.9% vs. 47.4%; p = 0.088). Locoregional recurrence-free survival (64.3% vs. 81.7%; p = 0.122) and distant metastasis-free survival (40.3% vs. 55.8%; p = 0.234) at two years did not show any statistical difference between two radiation modalities. In the multivariate analysis, extrahepatic cholangiocarcinoma, poorly-differentiated histologic grade, and higher stage were significant poor prognostic factors for survival. Severe treatment-related toxicity was not significantly different between two arms. Conclusions: IMRT showed comparable results with 3D-CRT in terms of recurrence, and survival, and radiotherapy toxicity for the postoperative treatment of biliary tract cancer.

Keywords

References

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