The Korean journal of internal medicine

  • 제34권4호
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  • Pages.858-866
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  • 2019
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease

  • Baek, Seon Ha (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Cha, Ran-hui (National Medical Center) ;
  • Kang, Shin Wook (Yonsei University College of Medicine) ;
  • Park, Cheol Whee (College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Cha, Dae Ryong (Korea University Ansan Hospital) ;
  • Kim, Sung Gyun (Hallym University Sacred Heart Hospital) ;
  • Yoon, Sun Ae (College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Kim, Sejoong (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Han, Sang-Youb (Inje University Ilsan Paik Hospital) ;
  • Park, Jung Hwan (Konkuk University Medical Center) ;
  • Chang, Jae Hyun (Gachon University Gil Medical Center) ;
  • Lim, Chun Soo (Seoul National University College of Medicine) ;
  • Kim, Yon Su (Seoul National University College of Medicine) ;
  • Na, Ki Young (Department of Internal Medicine, Seoul National University Bundang Hospital)
  • 투고 : 2017.02.11
  • 심사 : 2017.05.21
  • 발행 : 2019.07.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical outcomes in patients with CKD. We aimed to determine whether the level of circulating renalase was associated with CKD progression, MACCEs, and all-cause mortality, using data from a prospective randomized controlled study, Kremezin STudy Against Renal disease progression in Korea (K-STAR; NCT 00860431). Methods: A retrospective analysis of the K-STAR data was performed including 383 patients with CKD (mean age, 56.4 years; male/female, 252/131). We measured circulating renalase levels and examined the effects of these levels on clinical outcomes. Results: The mean level of serum renalase was 75.8 ± 34.8 ㎍/mL. In the multi-variable analysis, lower hemoglobin levels, higher serum creatinine levels, and diabetes mellitus were significantly associated with a higher renalase levels. Over the course of a mean follow-up period of 56 months, 25 deaths and 61 MACCEs occurred. Among 322 patients in whom these outcomes were assessed, 137 adverse renal outcomes occurred after a mean follow-up period of 27.8 months. Each 10-㎍/mL increase in serum renalase was associated with significantly greater hazards of all-cause mortality and adverse renal outcomes (hazard ratio [HR] = 1.112, p = 0.049; HR = 1.052, p = 0.045). However, serum renalase level was not associated with the rate of MACCEs in patients with CKD. Conclusions: Our results indicated that circulating renalase might be a predictor of mortality and adverse renal outcomes in patients with CKD.

키워드

과제정보

The authors would like to thank Soyeon Ahn, PhD (Medical Research Collaborating Center, Seoul National University Bundang Hospital) for valuable comments of statistical methods without compensation.

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