The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Extracellular vesicles in renal physiology and clinical applications for renal disease

  • Kwon, Soon Hyo (Division of Nephrology, Hyonam Kidney Laboratory, Soonchunhyang University Seoul Hospital)
  • Received : 2019.04.02
  • Accepted : 2019.04.13
  • Published : 2019.05.01
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Abstract

Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules. They are involved in cell-to-cell communication, immune modulation, and the removal of unwanted materials from cells. EVs have been studied as biomarkers of specific diseases and have potential therapeutic applications. Recent research has emphasized the functions of EVs in the kidney. This review provides an overview of recent findings related to the roles of EVs in the nephron, and their utility as biomarkers and therapeutic factors in renal disease.

Keywords

Acknowledgement

This research was partially supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A3B03029800) and the Soonchunhyang University Research Fund.

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