Parasites, Hosts and Diseases

  • 제57권3호
  • /
  • Pages.249-256
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  • 2019
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  • 2982-5164(pISSN)
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  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
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Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection

  • Tsai, Hung-Chin (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Chen, Yu-Hsin (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Yen, Chuan-Min (Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University) ;
  • Chung, Li-Yu (Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University) ;
  • Wann, Shue-Ren (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Lee, Susan Shin-Jung (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University) ;
  • Chen, Yao-Shen (Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University)
  • 투고 : 2019.02.03
  • 심사 : 2019.04.09
  • 발행 : 2019.06.30
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초록

Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform ${\beta}$ and ${\gamma}$ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 ${\beta}$, ${\gamma}$, ${\varepsilon}$, and ${\theta}$ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.

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참고문헌

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