DOI QR코드

DOI QR Code

Multi-slit prompt-gamma camera for locating of distal dose falloff in proton therapy

  • Park, Jong Hoon (Department of Nuclear Engineering, Hanyang University) ;
  • Kim, Sung Hun (Department of Nuclear Engineering, Hanyang University) ;
  • Ku, Youngmo (Department of Nuclear Engineering, Hanyang University) ;
  • Kim, Chan Hyeong (Department of Nuclear Engineering, Hanyang University) ;
  • Lee, Han Rim (Neutron Utilization Technology Division, Korea Atomic Energy Research Institute) ;
  • Jeong, Jong Hwi (Proton Therapy Center, National Cancer Center) ;
  • Lee, Se Byeong (Proton Therapy Center, National Cancer Center) ;
  • Shin, Dong Ho (IT Convergence Technology Research Laboratory, Electronics and Telecommunications Research Institute)
  • 투고 : 2018.09.18
  • 심사 : 2019.03.11
  • 발행 : 2019.06.25

초록

In this research, a multi-slit prompt-gamma camera was developed to locate the distal dose falloff of the proton beam spots in spot scanning proton therapy. To see the performance of the developed camera, therapeutic proton beams were delivered to a solid plate phantom and then the prompt gammas from the phantom were measured using the camera. Our results show that the camera locates the 90% distal dose falloff (= d90%), within about 2-3 mm of error for the spots which are composed $3.8{\times}10^8$ protons or more. The measured location of d90% is not very sensitive to the irradiation depth of the proton beam (i.e., the depth of proton beam from the phantom surface toward which the camera is located). Considering the number of protons per spot for the most distal spots in typical treatment cases (i.e., 2 Gy dose divided in 2 fields), the camera can locate d90% only for a fraction of the spots depending on the treatment cases. However, the information of those spots is still valuable in that, in the multi-slit prompt-gamma camera, the distal dose falloff of the spots is located solely based on prompt gamma measurement, i.e., not referring to Monte Carlo simulation.

키워드

참고문헌

  1. T.F. DeLaney, H.M. Kooy, Proton and Charged Particle Radiotherapy, Lippincott Williams & Wilkins, 2008.
  2. U. Oelfke, G.K.Y. Lam, M.S. Atkins, Proton dose monitoring with PET: quantitative studies in Lucite, Phys. Med. Biol. 41 (1996) 177-196. https://doi.org/10.1088/0031-9155/41/1/013
  3. M. Moteabbed, S. Espana, H. Paganetti, Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy, Phys. Med. Biol. 56 (2011) 1063-1082. https://doi.org/10.1088/0031-9155/56/4/012
  4. C.H. Min, C.H. Kim, M.Y. Youn, J.W. Kim, Prompt gamma measurements for locating the dose falloff region in the proton therapy, Appl. Phys. Lett. 89 (2006).
  5. J. Smeets, F. Roellinghoff, D. Prieels, F. Stichelbaut, A. Benilov, P. Busca, C. Fiorini, R. Peloso, M. Basilavecchia, T. Frizzi, J.C. Dehaes, A. Dubus, Prompt gamma imaging with a slit camera for real-time range control in proton therapy, Phys. Med. Biol. 57 (2012) 3371-3405. https://doi.org/10.1088/0031-9155/57/11/3371
  6. V. Bom, L. Joulaeizadeh, F. Beekman, Real-time prompt gamma monitoring in spot-scanning proton therapy using imaging through a knife-edge-shaped slit, Phys. Med. Biol. 57 (2012) 297-308. https://doi.org/10.1088/0031-9155/57/2/297
  7. I. Perali, A. Celani, L. Bombelli, C. Fiorini, F. Camera, E. Clementel, S. Henrotin, G. Janssens, D. Prieels, F. Roellinghoff, J. Smeets, F. Stichelbaut, F.V. Stappen, Prompt gamma imaging of proton pencil beams at clinical dose rate, Phys. Med. Biol. 59 (2014) 5849-5871. https://doi.org/10.1088/0031-9155/59/19/5849
  8. M. Priegnitz, S. Helmbrecht, G. Janssens, I. Perali, J. Smeets, F. Vander Stappen, E. Sterpin, F. Fiedler, Detection of mixed-range proton pencil beams with a prompt gamma slit camera, Phys. Med. Biol. 61 (2016) 855-871. https://doi.org/10.1088/0031-9155/61/2/855
  9. M. Frandes, A. Zoglauer, V. Maxim, R. Prost, A tracking compton-scattering imaging system for hadron therapy monitoring, IEEE Trans. Nucl. Sci. 57 (2010) 144-150. https://doi.org/10.1109/TNS.2009.2031679
  10. M.H. Richard, M. Chevallier, D. Dauvergne, N. Freud, P. Henriquet, F. Le Foulher, J.M. Letang, G. Montarou, C. Ray, F. Roellinghoff, E. Testa, M. Testa, A.H. Walenta, Design guidelines for a double scattering compton camera for prompt-${\gamma}$ Imaging during ion beam therapy: a Monte Carlo simulation study, IEEE Trans. Nucl. Sci. 58 (2011) 87-94. https://doi.org/10.1109/TNS.2010.2076303
  11. D. Mackin, S. Peterson, S. Beddar, J. Polf, Evaluation of a stochastic reconstruction algorithm for use in Compton camera imaging and beam range verification from secondary gamma emission during proton therapy, Phys. Med. Biol. 57 (2012) 3537-3553. https://doi.org/10.1088/0031-9155/57/11/3537
  12. J. Krimmer, J.L. Ley, C. Abellan, J.P. Cachemiche, L. Caponetto, X. Chen, M. Dahoumane, D. Dauyergne, N. Freud, B. Joly, D. Lambert, L. Lestand, J.M. Letang, M. Magne, H. Mathez, V. Maxim, G. Montarou, C. Morel, M. Pinto, C. Ray, V. Reithinger, E. Testa, Y. Zoccarato, Development of a Compton camera for medical applications based on silicon strip and scintillation detectors, Nucl. Instrum. Methods Phys. Res. Sect. A Accel. Spectrom. Detect. Assoc. Equip. 787 (2015) 98-101. https://doi.org/10.1016/j.nima.2014.11.042
  13. J.C. Polf, S. Avery, D.S. Mackin, S. Beddar, Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera:feasibility studies for range verification, Phys. Med. Biol. 60 (2015) 7085-7099. https://doi.org/10.1088/0031-9155/60/18/7085
  14. C.H. Kim, J.H. Park, H. Seo, H.R. Lee, Gamma electron vertex imaging and application to beam range verification in proton therapy, Med. Phys. 39 (2012) 1001-1005. https://doi.org/10.1118/1.4749930
  15. H.R. Lee, J.H. Park, J.H. Kim, W.G. Jung, C.H. Kim, Development of signal processing modules for double-sided silicon strip detector of gamma vertex imaging for proton beam dose verification, J. Radiat. Prot. 39 (2014) 81-88. https://doi.org/10.14407/jrp.2014.39.2.081
  16. C. Golnik, F. Hueso-Gonzalez, A. Muller, P. Dendooven, W. Enghardt, F. Fiedler, T. Kormoll, K. Roemer, J. Petzoldt, A. Wagner, G. Pausch, Range assessment in particle therapy based on prompt gamma-ray timing measurements, Phys. Med. Biol. 59 (2014) 5399-5422. https://doi.org/10.1088/0031-9155/59/18/5399
  17. F. Hueso-Gonzalez, W. Enghardt, F. Fiedler, C. Golnik, G. Janssens, J. Petzoldt, D. Prieels, M. Priegnitz, K.E. Romer, J. Smeets, F. Vander Stappen, A. Wagner, G. Pausch, First test of the prompt gamma ray timing method with heterogeneous targets at a clinical proton therapy facility, Phys. Med. Biol. 60 (2015) 6247-6272. https://doi.org/10.1088/0031-9155/60/16/6247
  18. M. Priegnitz, S. Helmbrecht, G. Janssens, I. Perali, J. Smeets, F. Vander Stappen, E. Sterpin, F. Fiedler, Measurement of prompt gamma profiles in inhomogeneous targets with a knife-edge slit camera during proton irradiation, Phys. Med. Biol. 60 (2015) 4849-4871. https://doi.org/10.1088/0031-9155/60/12/4849
  19. C.H. Min, H.R. Lee, C.H. Kim, S.B. Lee, Development of array-type prompt gamma measurement system for in vivo range verification in proton therapy, Med. Phys. 39 (2012) 2100-2107. https://doi.org/10.1118/1.3694098
  20. S.R. Cheery, J.A. Sorenson, M.E. Phelps, Physics in Nuclear Medicine, Elsevier, PA: Saunders, 2013.
  21. M. Andreotti, W. Baldini, R. Calabrese, G. Cibinetto, A.C. Ramusino, C. De Donato, R. Faccini, M. Fiorini, E. Luppi, R. Malaguti, A. Montanari, A. Pietropaolo, V. Santoro, G. Tellarini, L. Tomassetti, N. Tosi, Study of the radiation damage of Silicon Photo-Multipliers at the GELINA facility, J. Instrum. 9 (2014).
  22. R. Pagano, S. Lombardo, F. Palumbo, D. Sanfilippo, G. Valvo, G. Fallica, S. Libertino, Radiation hardness of silicon photomultipliers under $^{60}Co$ ${\gamma}$-ray irradiation, Nucl. Instrum. Methods Phys. Res. Sect. A Accel. Spectrom. Detect. Assoc. Equip. 767 (2014) 347-352. https://doi.org/10.1016/j.nima.2014.08.028
  23. D.G. Charlton, J.D. Dowell, R.J. Homer, P. Jovanovic, I.R. Kenyon, G. Mahout, H.R. Shaylor, A. Sibley, J.A. Wilson, J.H. Bibby, I.M. Gregor, R.L. Wastie, A.R. Weidberg, Radiation hardness and lifetime studies of photodiodes for the optical readout of the ATLAS semiconductor tracker, Nucl. Instrum. Methods Phys. Res. Sect. A Accel. Spectrom. Detect. Assoc. Equip. 456 (2001) 300-309. https://doi.org/10.1016/S0168-9002(00)00666-5
  24. J.H. Park, H.R. Lee, S.H. Kim, C.H. Kim, D.H. Shin, S.B. Lee, J.H. Jeong, Development of dual-mode signal processing module for multi-slit prompt-gamma camera, Kor. J. Med. Phys. 27 (2016) 37-45.
  25. H.R. Lee, J.H. Park, H.S. Kim, C.H. Kim, Development of multiplexing system for reduction of data acquisition channels of multi-channel radiation, in: The Korean Association for Radiation Protection Spring Meeting, Korea, April 24-26, 2013.
  26. H.R. Lee, J.H. Park, S.H. Kim, C.H. Kim, Development of prompt gamma measurement system based on CsI(Tl) detector array for proton beam range verification, in: IEEE Nuclear Science Symposium and Medical Imaging Conference and 19th International Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors, USA, October 27 - November 3, 2012.

피인용 문헌

  1. Prompt gamma imaging in proton therapy - status, challenges and developments vol.1561, 2019, https://doi.org/10.1088/1742-6596/1561/1/012021