Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
권호 표지
DOI QR코드

DOI QR Code

Möbius Syndrome Demonstrated by the High-Resolution MR Imaging: a Case Report and Review of Literature

  • Hwang, Minhee (Department of Radiology, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital) ;
  • Baek, Hye Jin (Department of Radiology, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital) ;
  • Ryu, Kyeong Hwa (Department of Radiology, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital) ;
  • Choi, Bo Hwa (Department of Radiology, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital) ;
  • Ha, Ji Young (Department of Radiology, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital) ;
  • Do, Hyun Jung (Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital)
  • Received : 2019.04.16
  • Accepted : 2019.05.13
  • Published : 2019.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

$M\ddot{o}bius$ syndrome is a rare congenital condition, characterized by abducens and facial nerve palsy, resulting in limitation of lateral gaze movement and facial diplegia. However, to our knowledge, there have been few studies on evaluation of cranial nerves, on MR imaging in $M\ddot{o}bius$ syndrome. Herein, we describe a rare case of $M\ddot{o}bius$ syndrome representing limitation of lateral gaze, and weakness of facial expression, since the neonatal period. In this case, high-resolution MR imaging played a key role in diagnosing $M\ddot{o}bius$ syndrome, by direct visualization of corresponding cranial nerves abnormalities.

Keywords

References

  1. Kim N, Kim JH, Kim JS, Hwang JM. Mobius syndrome: clinico-radiologic correlation. Graefes Arch Clin Exp Ophthalmol 2018;256:2219-2223 https://doi.org/10.1007/s00417-018-4089-3
  2. Pedraza S, Gamez J, Rovira A, et al. MRI findings in Mobius syndrome: correlation with clinical features. Neurology 2000;55:1058-1060 https://doi.org/10.1212/WNL.55.7.1058
  3. Saint-Martin C, Clapuyt P, Duprez T, Ghariani S, Verellen G. Mobius sequence and severe pons hypoplasia: a case report. Pediatr Radiol 1998;28:932 https://doi.org/10.1007/s002470050503
  4. Kuhn MJ, Clark HB, Morales A, Shekar PC. Group III Mobius syndrome: CT and MR findings. AJNR Am J Neuroradiol 1990;11:903-904
  5. Verzijl HT, Valk J, de Vries R, Padberg GW. Radiologic evidence for absence of the facial nerve in Mobius syndrome. Neurology 2005;64:849-855 https://doi.org/10.1212/01.WNL.0000152980.92436.D9
  6. Jeon SH, Choi KD, Oh SY, Hwang J-M, Kim JH, Kim JS. A case of Mobius syndrome with Duane's retraction syndrome. J Korean Neurol Assoc 2006;24:175-177
  7. Pandey PK, Shroff D, Kapoor S, et al. Bilateral incyclotorsion, absent facial nerve, and anotia: fellow travelers in Mobius sequence or oculoauriculovertebral spectrum? J AAPOS 2007;11:310-312 https://doi.org/10.1016/j.jaapos.2006.11.012
  8. Huang HT, Hwang CW, Lai PH, Chen CC. Mobius syndrome as a syndrome of rhombencephalic maldevelopment: a case report. Pediatr Neonatol 2009;50:36-38 https://doi.org/10.1016/S1875-9572(09)60028-0
  9. Park C, Kim JH, Hwang JM. Coexistence of Mobius syndrome and Duane's retraction syndrome. Graefes Arch Clin Exp Ophthalmol 2012;250:1707-1709 https://doi.org/10.1007/s00417-011-1816-4
  10. Verzijl HT, van der Zwaag B, Cruysberg JR, Padberg GW. Mobius syndrome redefined: a syndrome of rhombencephalic maldevelopment. Neurology 2003;61:327-333 https://doi.org/10.1212/01.WNL.0000076484.91275.CD
  11. Kumar D. Moebius syndrome. J Med Genet 1990;27:122-126 https://doi.org/10.1136/jmg.27.2.122
  12. Schmitz B, Hagen T, Reith W. Three-dimensional true FISP for high-resolution imaging of the whole brain. Eur Radiol 2003;13:1577-1582 https://doi.org/10.1007/s00330-003-1846-3