Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Synthetic Bacteria for Therapeutics

  • Lam VO, Phuong N. (School of Integrative Engineering, Chung-Ang University) ;
  • Lee, Hyang-Mi (School of Integrative Engineering, Chung-Ang University) ;
  • Na, Dokyun (School of Integrative Engineering, Chung-Ang University)
  • Received : 2019.04.10
  • Accepted : 2019.06.03
  • Published : 2019.06.28
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Abstract

Synthetic biology builds programmed biological systems for a wide range of purposes such as improving human health, remedying the environment, and boosting the production of valuable chemical substances. In recent years, the rapid development of synthetic biology has enabled synthetic bacterium-based diagnoses and therapeutics superior to traditional methodologies by engaging bacterial sensing of and response to environmental signals inherent in these complex biological systems. Biosynthetic systems have opened a new avenue of disease diagnosis and treatment. In this review, we introduce designed synthetic bacterial systems acting as living therapeutics in the diagnosis and treatment of several diseases. We also discuss the safety and robustness of genetically modified synthetic bacteria inside the human body.

Keywords

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