Korean Journal of Microbiology (미생물학회지)

The Microbiological Society of Korea (한국미생물학회)
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Therapeutic strategies to manage chronic wounds by using biofilm dispersal mechanisms

생물막 분산기작을 이용한 만성창상의 치료전략

  • Kim, Jaisoo (Department of Life Science, Kyonggi University) ;
  • Kim, Min-Ho (Department of Biological Sciences, Kent State University)
  • 김재수 (경기대학교 바이오융합학부 생명과학전공) ;
  • 김민호 (켄트주립대학교 생물학과)
  • Received : 2019.04.04
  • Accepted : 2019.05.09
  • Published : 2019.06.30
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Abstract

Most chronic wounds persist in the inflammatory phase during wound healing due to the biofilm. Biofilms are resistant to antibiotics, weakening penetration, resistance to biocides and weakening local immune responses. The biofilm is firmly attached to the surrounding tissues and is very difficult to remove. Therefore, strategies to remove hard biofilms without damaging surrounding tissue are very important. One of possible strategies is dispersal. So many studies have been done to develop new strategies using dispersal mechanisms. In this review paper, especially chemotaxis, phage therapy, polysaccharides, various enzymes (glycosidases, proteases, and deoxyribonucleases), surfactants, dispersion signals, autoinducers, inhibitors were introduced. Combination therapies with other therapies such as antibiotic therapy were also introduced. It is expected that the possibility of treatment of chronic wound infection using the knowledge of the biofilm dispersal mechanisms presented in this paper will be higher.

대부분의 만성창상(chronic wounds)은 생물막으로 인해 상처 치유시 염증단계를 지속시킨다. 생물막은 항생제(antibiotics)에 대한 저항성을 가지며 침투력을 저하시키고 살균제(biocides)에 대한 내성을 지니며 국소면역반응을 약화시킨다. 또한 생물막은 주변의 조직에 단단히 붙어 있어 제거하는 작업이 매우 어렵다. 그러므로 주변 조직을 손상시키지 않으면서 단단한 생물막을 제거하는 전략은 매우 중요하다. 그 중에 하나가 분산기작을 이용한 생물막의 해체이며 지금까지 많은 연구가 수행되어 왔다. 본 고찰논문에서는 특별히 화학주성, 파지요법, 다당류, 다양한 효소(당분해효소, 단백질분해효소, DNA 분해효소), 계면활성제, 분산신호, 자기유도인자, 조절인자, 억제제 등이 소개되었으며 더 나아가 항생제 치료 및 다른 치료와의 병행을 통한 병합요법도 소개되었다. 앞으로 본 논문에서 제시된 생물막의 분산기작의 지식을 이용하여 만성 창상 감염치료의 가능성이 더 높아지길 기대한다.

Keywords

MSMHBQ_2019_v55n2_87_f0001.png 이미지

Fig. 1. The life cycle of biofilm.

MSMHBQ_2019_v55n2_87_f0002.png 이미지

Fig. 2. The steps of biofilm dispersal.

Table 1. List of active dispersal mechanisms that may be useful for wound infection treatments

MSMHBQ_2019_v55n2_87_t0001.png 이미지

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