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The Difference in Serum Ferritin and Leukocyte Regarding Overweight and Obese South Korean Adults

한국 성인의 비만과 과체중에 따른 혈청 페리틴과 백혈구의 차이

  • Lee, Hea Shoon (Department of Nursing, College of Life Science and Nano Technology, Hannam University)
  • Received : 2018.12.30
  • Accepted : 2019.02.27
  • Published : 2019.05.31

Abstract

Purpose: The purpose of this study was to investigate the difference in serum ferritin and leukocyte regarding overweight and obese South Korean adults. Methods: This study was conducted on 5,281 subjects older than 19, according to data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-3), 2015. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffe's test, Pearson's correlation coefficient, and stepwise multiple regression analysis (SPSS 24.0). Results: First, serum ferritin and leukocyte were higher regardubg obesity, followed by being overweight and within normal weight. Second, body mass index (BMI) was positively correlated with serum ferritin and leukocyte. Third, factors affecting serum ferritin were gender, and being obese and overweight. Explanatory power of the model was 26.2%. Factors affecting leukocyte were gender, obesity, being overweight, and weight change over the past year (weight gain). Explanatory power of the model was 10.2%. Conclusion: Obesity and being overweight were factors affecting serum ferritin and leukocyte, and obesity was more affected than being overweight in Koreans older than 19. In conclusion, serum ferritin was a marker of inflammation, rather than iron status, in overweight and obese Korean adults.

Keywords

References

  1. World Health Organization. Obesity and Overweight [Internet]. Geneva: World Health Organization; 2017, [cited 2019 March 5]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
  2. Kelly F. Obesity Is Now A Disease, American Medical Association Decides[internet]. Brighton: Healthline Media UK Ltd;2013 [cited 2018 May 10]. Available from: https://www.medicalnewstoday.com/articles/262226.php.
  3. Kohlgruber AL, Lynch L. Adipose tissue inflammation in the pathogenesis of type 2 diabetes. Current Diabetes Reports. 2015;15(11):92. https://doi.org/10.1007/s11892-015-0670-x.
  4. Bansal PG, Toteja GS, Bhatia N, Vikram NK, Siddhu A, Garg AK, et al. Deficiencies of serum ferritin and vitamin B12, but not folate, are common in adolescent girls residing in a slum in Delhi. International Journal for Vitamin and Nutrition Research 2015;85(1-2):14-22. https://doi.org/10.1024/0300-9831/a000219
  5. O'Brien HT, Blanchet R, Gagne D, Lauzi'ere J, Vezina C. Using soluble transferrin receptor and taking inflammation into account when defining serum ferritin cutoffs improved the diagnosis of iron deficiency in a group of Canadian preschool Inuit children from Nunavik. Anemia. 2016; Article ID 6430214. https://doi.org/10.1155/2016/6430214
  6. Kim JW, Kim DH, Roh YK, Ju SY, Nam HY, Nam GE, et al. Serum ferritin levels are positively associated with metabolically obese normal weight: a nationwide population-based study. Medicine. 2015; 94(52): Article ID e2335. https://doi.org/10.1097/MD.0000000000002335
  7. McClung JP, Andersen NE, Tarr TN, Stahl CH, Young AJ. Physical activity prevents augmented body fat accretion in moderately iron-deficient rats. The Journal of Nutrition. 2008;138(7):1293-1297. https://doi.org/10.1093/jn/138.7.1293
  8. Cheng HL, Bryant C, Cook R, O'Connor H, Rooney K, Steinbeck K. The relationship between obesity and hypoferraemia in adults: A systematic review. Obesity Reviews. 2012;13(2):150-161. https://doi.org/10.1111/j.1467-789X.2011.00938.x.
  9. Pinhas-Hamiel O, Newfield RS, Koren I, Agmon A, Lilos P, Phillip M. Greater prevalence of iron deficiency in overweight and obese children and adolescents. International Journal of Obesity. 2003;27(3):416-418. https://doi.org/10.1038/sj.ijo.0802224
  10. Lecube A, Carrera A, Losada E, Hernandez C, Simo R, Mesa J. Iron deficiency in obese postmenopausal women. Obesity. 2006;14(10):1724-1730. https://doi.org/10.1038/oby.2006.198
  11. Jerico C, Breton I, Garcia Ruiz de GA, de Oliveira AC, Rubio MA, Tinahones FJ, et al. Diagnosis and treatment of iron deficiency, with or without anemia, before and after bariatric surgery. Endocrinologiay nutricion. 2016; 63(1):32-42. https://doi.org/10.1016/j.endonu.2015.09.003
  12. Khan A, Khan WM, Ayub M, Humayun M, Haroon M. Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People. Journal of Obesity. 2016; Article ID 1937320. https://doi.org/10.1155/2016/1937320
  13. Park SK, Choi WJ, Oh CM, Kim JE, Shin HH, Ryoo JH. Association between serum ferritin levels and the incidence of obesity in Korean men: A prospective cohort study. Endocrine Journal. 2014; 61(3):215-224. https://doi.org/10.1507/endocrj.EJ13-0173
  14. Abdelmageed E, Duria AR, Renda E, Abdelmageed IA, Gasim IG. High level of hemoglobin, white blood cells and obesity among Sudanese women in early pregnancy: a cross-sectional study. Future science OA. 2017; 3(2): FSO182. https://doi.org /10.4155/fsoa-2016-0096.
  15. Zhang SZ, Jin YP, Qin GM, Association of platelet-monocyte aggregates with platelet activation, systemic inflammation, and myocardial injury in patients with non-ST elevation acute coronary syndromes. Clinical cardiology. 2007;30(1):26-31. https://doi.org/10.1002/clc.2
  16. Imano H, Sato S, Kitamura A, Kiyama M, Ohira T, Shimamoto T, et al. Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese men. Atherosclerosis. 2007;195(1):147-152. https://doi.org/10.1016/j.atherosclerosis.2006.09.002
  17. Dixon JB, O'Brien PE. Obesity and the white blood cell count: changes with sustained weight loss. Obesity Surgery. 2006;16(3):251-257. https://doi.org/10.1381/096089206776116453
  18. Sim KW, Lee SH, Lee HS. The relationship body mass index and morbidity in Korea. Journal of Korean Society for the Study of Obesity. 2001;10(2):147-155.
  19. World Health Organization Western Pacific Region. The Asia-pacific perspective: Redefining obesity and its Treatment. Australia: WHO Western Pacific Region, 2000.
  20. Cepeda-Lopez AC, Aeberli I, Zimmermann MB. Does obesity increase risk for iron deficiency? a review of the literature and the potential mechanisms. International Journal for Vitamin and Nutrition Research. 2010;80(45):263-270. https://doi.org/10.1024/0300-9831/a000033
  21. Shiwaku K, Anuurad E, Enkhmaa B, Kitajima K, Yamane Y. Appropriate BMI for Asian populations. The Lancet. 2004;363(1077):157-163. https://doi.org/10.1016/S0140-6736(04)15856-X
  22. Lecube A, Hernandez C, Pelegri D, Simo R. Factors accounting for high ferritin levels in obesity. International Journal of Obesity. 2008;32(11):1665-1669. https://doi.org/10.1038/ijo.2008.154
  23. Villarroel HP, Arredondo OM, Olivares GM. Hepcidin as a central mediator of anemia of chronic diseases associated with obesity. Revista Medica de Chile. 2013;141(7):887-894. https://doi.org/10.4067/S0034-98872013000700008
  24. Jamshidi L, Sief A. Association Between Obesity, White Blood Cell and Platelet Count. Zahedan Journal of Research in Medical Sciences.2017;9(2):e4955. https://doi.org/10.5812/zjrms.4955.
  25. Herishanu Y, Rogowski O, Polliack A. Leukocytosis in obese individuals: possible link in patients with unexplained persistent neutrophilia. European Journal of Haematology. 2006;76(6):516-520. https://doi.org/10.1111/j.1600-0609.2006.00658.x
  26. Panagiotakos DB, Pitsavos C, Yannakoulia M, Chrysohoou C, Stefanadis C. The implication of obesity and central fat on markers of chronic inflammation: the ATTICA study. Atherosclerosis. 2005;183(2):308-315. https://doi.org/10.1016/j.atherosclerosis.2005.03.010
  27. Samocha-Bonet D, Justo D, Rogowski O, Saar N, Abu-Abeid S, Shenkerman G, et al. Platelet counts and platelet activation markers in obese subjects. Mediators Inflammation. 2008; Article ID 834153: 6. https://doi.org/10.1155/2008/834153