Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Evaluation of Absorbed Dose According to Nanoparticle Density During the Breast Cancer Brachytherapy

유방암 근접치료 시 나노입자의 밀도에 따른 흡수선량 평가

  • Lee, Deuk-Hee (Department of Radiation Oncology, Busan Paik Hospital, Inje University) ;
  • Nam, Ji-Hee (Department of Radiology, Busan Paik Hospital, Inje University) ;
  • Kim, Jung-Hoon (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan)
  • 이득희 (인제대학교 부산백병원 방사선종양학과) ;
  • 남지희 (인제대학교 부산백병원 영상의학과) ;
  • 김정훈 (부산가톨릭대학교 보건과학대학 방사선학과)
  • Received : 2019.02.12
  • Accepted : 2019.04.18
  • Published : 2019.04.30
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Abstract

The purpose of this study was to evaluate the efficacy of brachytherapy of breast cancer by dose assessment which a steady increased in Korea women. The dose assessment was performed using the MCNPX program, a MonteCarlo simulation technique. The sources used for brachytherapy was 192Ir. And nanoparticle which used for dose enhancement was gold. The density of nanoparticle was 7, 18 and 30 mg. Evaluation of absorbed dose according to distance is measured at a distance of 30, 50, 100 and 200 cm from the patient. As a result, The breast absorbed dose results increased in proportion to the density of nanoparticle. And the surrounding organs were not significantly different according to the density. But, in some organs, the absorbed dose decreased as the density of nanoparticles increased. Absorbed dose according to the distance was in inverse proportion to distance.

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References

  1. National Cancer Information Center, https://www.cancer.go.kr
  2. Moore MA. Cancer control programs in East Asia: evidence from the international literature. Journal of Preventive Medicine & Public Health. 2014 Jul;47(4):183-200. https://doi.org/10.3961/jpmph.2014.47.4.183
  3. Jung KW, Won YJ, Kong HJ, Oh CM, Lee DH, Lee JS. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2011. Cancer Research and Treatment. 2014 Apr;46(2):109-23. https://doi.org/10.4143/crt.2014.46.2.109
  4. Korean Breast Cancer Society, http://www.kbcs.or.kr
  5. Kang SS, Go IH, Kim GJ, Kim SH, Kim YS, Kim YJ, et al. Radiation Therapeutics. 3rd ed. Seoul, Korea: Chung-ku munhwasa; 2014.
  6. Khan FM. The Physics of Radiation Therapy. 3rd ed. Philadelphia, USA: Lippincott Williams & Wilkins; 2009.
  7. Hwang CH. A Study on Physical Properties and Secondary Particles in Radiation Dose Enhancement [dissertation]. Busan: Catholic University of Pusan; 2018.
  8. Park ET, Lee DH, Im IC. Evaluation of Absorbed Dose According to the Nanoparticle in Prostate Cancer Brachytherapy. Journal of the Korean Society Radiology. 2018:12(2):167-72. https://doi.org/10.7742/JKSR.2018.12.2.167
  9. Chithrani DB, Jelveh S, Jalali F, Prooijen MV, Allen C, Bristow RG, et al. Gold nanoparticles as radiation sensitizers in cancer therapy. Radiation Research, 2010 Jun;173(6):719-28. https://doi.org/10.1667/RR1984.1
  10. Duc GL, Miladi I, Alric C, Mowat P, BrBuer-Krisch E, Bouchet A, et al. Toward an image-guided microbeam radiation therapy using gadolinium-based nanoparticle. ACS nano. 2011 Oct;5(12):9566-74. https://doi.org/10.1021/nn202797h
  11. Khoei S, Mahdavi SR, Fakhimikabir H, Shakeri-Zadeh A, Hashemian A. The role of iron oxide nanoparticles in the radiosensitization of human prostate carcinoma cell line DU145 at megavoltage radiation energies. International Journal of Radiation Biology. 2014 May;90(5):351-6. https://doi.org/10.3109/09553002.2014.888104
  12. Park ET, Kim JH. Dose Evaluation of the Man Adjacent to an Implanted Patient During the Prostate Cancer Brachytherapy. Journal of the Korean Society Radiology. 2016:10(1):39-44. https://doi.org/10.7742/jksr.2016.10.1.39
  13. Kim JH, Kim CS, Hwang CH. A Monte Carlo Study of Dose Enhancement according to the Enhancement Agents. Journal of Radiological Science and Technology. 2017:40(1):93-9. https://doi.org/10.17946/JRST.2017.40.1.14
  14. Ghorbani M, Bakhshabdi M, Golshan A, Knaup C. Dose enhancement by various nanoparticles in prostate brachytherapy. Australasian Physical and Engineering Science in Medicine. 2013 Dec;36(4):431-40. https://doi.org/10.1007/s13246-013-0231-z
  15. Mesbahi A, Jamali F, Gharehaghaji N. Effect of photon beam energy, gold nanoparticle size and concentration on the dose enhancement in radiation therapy. BioImpacts. 2013:3(1):29-35. https://doi.org/10.5681/bi.2013.002
  16. Berbeco R, Korideck H, Ngwa W, Kumar R, Patel J, Sridhar S, et al. TU-C-BRB-11: In vitro dose enhancement from gold nanoparticles under different clinical MV photon beam configurations. Medical Physics. 2012 Jun;39(6):3900-1.
  17. Brun E, Sanche L, Sicard-Roselli C. Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution. Colloids and Surfaces B: Biointerfaces. 2009 Aug;72(1):128-34. https://doi.org/10.1016/j.colsurfb.2009.03.025
  18. Chen PC, Mwakwari SC, Oyelere AK. Gold nanoparticles: from nanomedicine to nanosensing. Nanotechnology, Science and Applications. 2008 Nov;2(1):45-66.
  19. Park ET, Kim JH, Im IC. Radiation Dose Calculation using MIRD TYPE PHANTOM in the surrounding Organs during Brachyherapy of Breast Cancer. Journal of the Korean Society Radiology. 2016;10(4):271-8. https://doi.org/10.7742/jksr.2016.10.4.271
  20. Jang DG, Ko SJ, Kim CS, Kim JH. Evaluation of Stability using Monte Carlo Simulation in 2 People Isolation Treatment Room of Radiation Iodine. Journal of Radiological Science and Technology. 2016;39(3):385-90. https://doi.org/10.17946/JRST.2016.39.3.12