Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Application of a Cyclooxygenase Inhibitor and Itraconazole for Pulmonary Squamous Cell Carcinoma in a Dog

  • Bae, Seul-gi (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Oh, Tae-ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
  • Received : 2018.10.18
  • Accepted : 2019.02.24
  • Published : 2019.04.30
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Abstract

A dog with anorexia, cough, and regurgitation was referred to clinic. Diagnostic imaging revealed a solitary mass involving the right cranial and middle lung lobes, compression of the cranial vena cava, and deviation of the heart and mediastinum toward the left side because the mass. The mass was diagnosed as a squamous cell carcinoma via fine needle aspiration. Ten days later, the tumor was larger and the clinical signs were more severe. A combination of piroxicam and itraconazole was administered to control the mass. Two weeks after initiating this treatment, the tumor size decreased and the clinical signs improved significantly.

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References

  1. Aftab BT, Dobromilskaya I, Liu JO, Rudin CM. Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Cancer Res 2011; 71: 6764-6772. https://doi.org/10.1158/0008-5472.CAN-11-0691
  2. Andersen S, Donnem T, Al-Saad S, Al-Shibli K, Busund LT, Bremnes RM. Angiogenic markers show high prognostic impact on survival in marginally operable non-small cell lung cancer patients treated with adjuvant radiotherapy. J Thorac Oncol 2009; 4: 463-471. https://doi.org/10.1097/JTO.0b013e3181991d18
  3. Boria PA, Murry DJ, Bennett PF, Glickman NW, Snyder PW, Merkel BL, Schlittler DL, Mutsaers AJ, Thomas RM, Knapp DW. Evaluation of cisplatin combined with piroxicam for the treatment of oral malignant melanoma and oral squamous cell carcinoma in dogs. J Am Vet Med Assoc 2004; 224: 388-394. https://doi.org/10.2460/javma.2004.224.388
  4. Devesa SS, Bray F, Vizcaino AP, Parkin DM. International lung cancer trends by histologic type: male: female differences diminishing and adenocarcinoma rates rising. Int J Cancer 2005; 117: 294-299. https://doi.org/10.1002/ijc.21183
  5. Hahn F, Muggenburg B, Griffith W. Primary lung neoplasia in a beagle colony. Vet Pathol 1996; 33: 633-638. https://doi.org/10.1177/030098589603300601
  6. Hida T, Kozaki K, Muramatsu H, Masuda A, Shimizu S, Mitsudomi T, Sugiura T, Ogawa M, Takahashi T. Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. Clin Cancer Res 2000; 6: 2006-2011.
  7. Horsman MR, Siemann DW. Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Res 2006; 66: 11520-11539. https://doi.org/10.1158/0008-5472.CAN-06-2848
  8. Kim DJ, Kim J, Spaunhurst K, Montoya J, Khodosh R, Chandra K, Fu T, Gilliam A, Molgo M, Beachy PA. Openlabel, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. J Clin Oncol 2014; 32: 745-751. https://doi.org/10.1200/JCO.2013.49.9525
  9. Knapp DW, Richardson RC, Bottoms GD, Teclaw R, Chan TC. Phase I trial of piroxicam in 62 dogs bearing naturally occurring tumors. Cancer Chemother Pharmacol 1992; 29: 214-218. https://doi.org/10.1007/BF00686255
  10. Mohammed SI, Bennett PF, Craig BA, Glickman NW, Mutsaers AJ, Snyder PW, Widmer WR, DeGortari AE, Bonney PL, Knapp DW. Effects of the cyclooxygenase inhibitor, piroxicam, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. Cancer Res 2002; 62: 356-358.
  11. Moulton J, Tscharner CV, Schneider R. Classification of lung carcinomas in the dog and cat. Vet Pathol 1981; 18: 513-528. https://doi.org/10.1177/030098588101800409
  12. Ogilvie G, Haschek W, Withrow S, Richardson R, Harvey H, Henderson R, Fowler J, Norris A, Tomlinson J, McCaw D. Classification of primary lung tumors in dogs: 210 cases (1975-1985). J Am Vet Med Assoc 1989; 195: 106-108.
  13. Rudin CM, Brahmer JR, Juergens RA, Hann CL, Ettinger DS, Sebree R, Smith R, Aftab BT, Huang P, Liu JO. Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer. J Thorac Oncol 2013; 8: 619-623. https://doi.org/10.1097/JTO.0b013e31828c3950
  14. Sandler AB, Dubinett SM. COX-2 inhibition and lung cancer. Semin Oncol 2004; 31: 45-52. https://doi.org/10.1053/j.seminoncol.2004.03.045
  15. Thun MJ, Henley SJ, Patrono C. Nonsteroidal antiinflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 2002; 94: 252-266. https://doi.org/10.1093/jnci/94.4.252