한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제32권2호
  • /
  • Pages.133-137
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  • 2019
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  • 1225-4339(pISSN)
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  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
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Anti-Oxidant Effects of Highly Bioavailable Curcumin Powder in High-Fat Diet Fed- and Streptozotocin-Induced Type 2 Diabetic Rats

  • 투고 : 2019.03.25
  • 심사 : 2019.04.12
  • 발행 : 2019.04.30
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초록

Curcumin is a hydrophobic polyphenol extracted from turmeric that exhibits a variety of biological functions has albeit with limited efficacy as a functional food material owing to its low absorption when administered orally. The newly developed curcumin powder formulation exhibits improved absorption rate in vivo. This study evaluates the anti-oxidant effects of $Theracurmin^{(R)}$ (TC), which is highly bio-available in curcumin powder. The antioxidant activity of TC was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferrous reducing antioxidant power (FRAP) assays, NO radical, superoxide radical, $H_2O_2$ scavenging activity, and total antioxidant capacity (TAC). Additionally, we evaluated the antioxidant activity of TC in high-fat diet (HFD)-fed streptozotocin (STZ)-induced Type 2 diabetic rats. As a result of oral administration of TC for 13 weeks in type 2 diabetic rats, the group administration of 2,000 mg/kg significantly increased FRAP, superoxide dismutase (SOD), and reduced the level of glutathione (GSH) in liver tissue 1.9, 1.2, and 1.2-times, respectively. Furthermore, serum TAC levels increased by 1.3-fold after the rats were administered with a dose of 500 mg/kg. These results were consistent with the in vitro assay results. In conclusion, TC exhibited its potential as a functional food material through its antioxidant properties.

키워드

HGSPB1_2019_v32n2_133_f0001.png 이미지

Fig. 1. In vitro antioxidant effects of Theracurmin® (TC).

Table 1. Composition of feed

HGSPB1_2019_v32n2_133_t0001.png 이미지

Table 2. Effect of Theracurmin® (TC) on blood glucose levels and antioxidant enzyme activities in liver tissue and serum in normal and T2DM rats

HGSPB1_2019_v32n2_133_t0002.png 이미지

참고문헌

  1. Antony S, Kuttan R, Kuttan G. 1999. Immunomodulatory activity of curcumin. Immunol Invest 28:291-303 https://doi.org/10.3109/08820139909062263
  2. Brownlee M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820 https://doi.org/10.1038/414813a
  3. Cha EJ, Pyo MY, Yang KS, Kim AK. 2008. Effect of Phellinus linteus extract on the activity of antioxidant enzyme. J Cancer Prev 13:311-315
  4. Dairam A, Limson JL, Watkins GM, Antunes E, Daya S. 2007. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. J Agric Food Chem 55:1039-1044 https://doi.org/10.1021/jf063446t
  5. Fontana M, Mosca L, Rosei MA. 2001. Interaction of enkephalins with oxyradicals. Biochem Pharmacol 61:1253-1257 https://doi.org/10.1016/S0006-2952(01)00565-2
  6. Giacco F, Brownlee M. 2010. Oxidative stress and diabetic complications. Circ Res 107:1058-1070 https://doi.org/10.1161/CIRCRESAHA.110.223545
  7. Jang HH, Nam SY, Kim MJ, Kim JB, Kim HR, Lee YM. 2014. Antioxidant activity and protective effects of anthocyanins-rich fraction from Korean purple sweet potato variety, "Shinjami" against oxidative stress in HepG2 cell. Korean J Food Nutr 27:1090-1095 https://doi.org/10.9799/ksfan.2014.27.6.1090
  8. Kim YH, Shin KO, Choi KS. 2016. In vitro antioxidant properties of equisetum arvense and its effects on serum lipid levels in mice fed a high-fat diet. Korean J Food Nutr 29:347-356 https://doi.org/10.9799/ksfan.2016.29.3.347
  9. Kuttan R, Sudheeran PC, Josph CD. 1987. Turmeric and curcumin as topical agents in cancer therapy. Tumori 73:29-31 https://doi.org/10.1177/030089168707300105
  10. Marcocci L, Maguire JJ, Droy-lefaix MT, Packer L. 1994. The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761. Biochem Biophys Res Commun 201:748-755 https://doi.org/10.1006/bbrc.1994.1764
  11. Matsuda H, Tewtrakul S, Morikawa T, Nakamura A, Yoshikawa M. 2004. Anti-allergic principles from Thai zedoary: Structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorg Med Chem 12:5891-5898 https://doi.org/10.1016/j.bmc.2004.08.027
  12. Park HJ, Tahashi H, Atsushi I, Ahn YJ. 2015. Absorption improvement of curcumin powder using $Theracurmin^{(R)}$ CR-033P. Food Sci Ind 48:42-46
  13. Ram A, Das M, Ghosh B. 2003. Curcumin attenuates allergeninduced airway hyperresponsiveness in sensitized guinea pigs. Biol Pharm Bull 26:1021-1024 https://doi.org/10.1248/bpb.26.1021
  14. Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T. 2011. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull 34:660-665 https://doi.org/10.1248/bpb.34.660
  15. Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. 2005. Combination of high-fat diet-fed and low-dose streptozotocintreated rat: A model for type 2 diabetes and pharmacological screening. Pharmacol Res 52:313-320 https://doi.org/10.1016/j.phrs.2005.05.004
  16. Wahlstrom B, Blennow G. 1978. A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol (Copenh) 43:86-92 https://doi.org/10.1111/j.1600-0773.1978.tb02240.x
  17. Wright E Jr, Scism-Bacon JL, Glass LC. 2006. Oxidative stress in type 2 diabetes: The role of fasting and postprandial glycaemia. Int J Clin Pract 60:308-314 https://doi.org/10.1111/j.1368-5031.2006.00825.x