Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Efficacy and Safety of High Dose MOK Pharmacopuncture in Hypothyroidism-induced Rats with Propylthiouracil

PTU 투여 갑상선기능저하증 유발 랫드모델에서 고용량 MOK 약침의 효능 및 안전성 평가 연구

  • Hwang, Ji Hye (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University) ;
  • Im, Wu Hyun (Namsangcheon Herbal Medicine Dispensary) ;
  • Jung, Chul (Namsangcheon Herbal Medicine Dispensary) ;
  • Jung, Hyo Won (Department of Herbology, College of Korean Medicine, Dongguk University)
  • 황지혜 (가천대학교 한의과대학 침구의학과) ;
  • 임우현 (남상천한의원 원외탕전실) ;
  • 정철 (남상천한의원 원외탕전실) ;
  • 정효원 (동국대학교 한의과대학 본초학교실)
  • Received : 2019.02.05
  • Accepted : 2019.04.30
  • Published : 2019.04.25
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Abstract

In this study, we investigated the effects of MOK pharmacopuncture at high-doses which are increased 10 to 100-fold in clinics, on propylthiouracil (PTU)-induced hypothyroidism in rats and the safety. We measured the changes of body weight, food and water intake, body temperature, the serum levels of thyroid hormones (TSH, T3, and T4), AST and ALT, glucose, lipid metabolites (total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride) and observed histopathological changes of thyroid tissues by H&E staining. We also analyzed the peaks of constituents of MOK using HPLC. In the results, the treatment of MOK pharmacopuncture at high-dose (30 mg/kg) in hypothyroidism-induced rats for 2 weeks was shown the improvement effects on the decrease of body weight, food intake, and body temperature, The MOK pharmacopunture at high dose regulated the imbalance of thyroid hormones, glucose, and lipid metabolites and also inhibited the structural damages of thyroid tissues. In liver damage, the MOK pharmacopuncture at high dose reduced the increase of AST and ALT levels in hypothyroid rats. We identified the MOK constituents in HPLC analysis. In conclusion, the treatment of MOK pharmacopuncture at high dose has a therapeutic effect on hypothyroidism without liver toxicity, suggesting that the MOK pharmacopuncture be usefully applicable to treat with hypothyroidism in clinics.

Keywords

References

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