Archives of Craniofacial Surgery (대한두개안면성형외과학회지)

Korean Cleft Palate-Craniofacial Association (대한두개안면성형외과학회)
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Upper eyelid Merkel cell carcinoma treated with neoadjuvant chemotherapy and surgical excision

  • Toto, Vito (Department of Plastic, Reconstructive and Aesthetic Surgery, Campus Bio-Medico di Roma University) ;
  • Colapietra, Alfredo (Department of Plastic, Reconstructive and Aesthetic Surgery, Campus Bio-Medico di Roma University) ;
  • Alessandri-Bonetti, Mario (Department of Plastic, Reconstructive and Aesthetic Surgery, Campus Bio-Medico di Roma University) ;
  • Vincenzi, Bruno (Department of Oncology, Campus Bio-Medico di Roma University) ;
  • Devirgiliis, Valeria (Department of Dermatology and Venereology, Sapienza University) ;
  • Panasiti, Vincenzo (Department of Plastic, Reconstructive and Aesthetic Surgery, Campus Bio-Medico di Roma University) ;
  • Persichetti, Paolo (Department of Plastic, Reconstructive and Aesthetic Surgery, Campus Bio-Medico di Roma University)
  • Received : 2018.08.21
  • Accepted : 2019.01.25
  • Published : 2019.04.20
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Abstract

Merkel cell carcinoma is a rare cutaneous carcinoma, featured by an aggressive clinical course and a mortality rate of 28% at 2 years. A 71-year-old female was affected by a 4.1-cm-wide locally advanced Merkel cell carcinoma of the upper eyelid, previously misdiagnosed as chalazion, with involvement of the extraocular muscles. Although the tumor showed a macroscopic spontaneous regression in size after the incisional biopsy, the mass was treated with neoadjuvant chemotherapy and surgical excision. Good functional and aesthetic result with preservation of the eyeball and absence of tumor recurrence were achieved at 3-year follow-up. In our experience, the combination of the inflammatory cascade due to the incisional biopsy and neoadjuvant chemotherapy led to the regression of a locally advanced large Merkel cell carcinoma of the eyelid.

Keywords

References

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