Journal of the Korean Burn Society (대한화상학회지)

Korean Burn Society (대한화상학회)
권호 표지

Feasibility of TRPM8 Agonist Agent for Management of Skin Graft Donor Site

화상 재건을 위한 식피술 공여부의 반흔 관리에 있어 TRPM8 Agonist 제재의 유용성

  • Choi, Jangyoun (Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Jung, Ee Room (Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Cho, Jin Tae (Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Seo, Bommie Florence (Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Choi, Jong Yun (Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kwon, Ho (Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Jung, Sung-No (Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 최장연 (가톨릭대학교 의과대학 의정부성모병원 성형외과학교실) ;
  • 정이룸 (가톨릭대학교 의과대학 의정부성모병원 성형외과학교실) ;
  • 조진태 (가톨릭대학교 의과대학 의정부성모병원 성형외과학교실) ;
  • 서보미 (가톨릭대학교 의과대학 의정부성모병원 성형외과학교실) ;
  • 최종윤 (가톨릭대학교 의과대학 의정부성모병원 성형외과학교실) ;
  • 권호 (가톨릭대학교 의과대학 의정부성모병원 성형외과학교실) ;
  • 정성노 (가톨릭대학교 의과대학 의정부성모병원 성형외과학교실)
  • Received : 2019.11.01
  • Accepted : 2019.11.25
  • Published : 2019.12.31

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Abstract

Purpose: Wound healing and scar management of donor site after skin graft should not be overlooked. Patients continue to complain of dryness, itching sensation. Such discomfort can cause irritation to the patients and lead to delayed healing or secondary infection. Thus, the author predicted Eucalyptus Oil, which acts on Transient Receptor Potential Melastatin 8 would be effective in regulating scar by reducing itching sensation in donor site when combining conventional silicone materials. Methods: The study was performed on 30 patients who underwent split thickness skin graft with lateral thigh as donor site between January 2017 and August 2018. First, primary evaluation of fully epithelized donor site scar three weeks after surgery was conducted. Control group (n=15) applied silicone gel (Kelo-cote, USA) solely two times a day. study group (n=15) applied Eucalyptus oil, combined with silicone gel. After 3 months of follow up, donor scar was evaluated using Vancouver scar scale and VAS scores of subjective patient reports regarding pain and itching sensation. Results: It was confirmed that both groups showed stable scar improvement comparing scar quality for 3 months. After 3 months, scar quality in study group showed superiority in pigmentation, pliability and pruritus compared to control group. Conclusion: Application of Eucalyptus Oil combined with conventional silicone gel is favorable to scar management and may give additional benefit of alleviating pruritis symptoms.

Keywords