Fig. 1. Antioxidative component content of solvent extract from broccoli sprout and broccoli.
Fig. 2. Antioxidant activity of solvent extract from broccoli sprout and broccoli.
Fig. 3. Macrophage (RAW 264.7 cell line) viability of solvent extract from broccoli sprout and broccoli.
Fig. 4. Anti-inflammatory activity of solvent extract from broccoli sprout and broccoli in LPS-induced RAW 264.7 cell.
Fig. 5. Splenocyte mitogenic activity of solvent extract from broccoli sprout and broccoli.
Fig. 6. Macrophage stimulating activity of solvent extract from broccoli sprout and broccoli.
References
- Alazawi W, Pirmadjid N, Lahiri R, Bhattacharya S. 2016. Inflammatory and immune responses to surgery and their clinical impact. Ann Surg 264:73-80 https://doi.org/10.1097/SLA.0000000000001691
- Cao Y, Zhao D, Xu AT, Shen J, Ran ZH. 2015. Effects of immunosuppressants on immune response to vaccine in inflammatory bowel disease. Chin Med J (Engl) 128:835-838 https://doi.org/10.4103/0366-6999.152683
- Choi Y, Lee SM, Chun J, Lee HB, Lee J. 2006. Influence of heat treatment on the antioxidant activities and polyphenolic compounds of Shiitake (Lentinus edodes) mushroom. Food Chem 99:381-387 https://doi.org/10.1016/j.foodchem.2005.08.004
- Conrad RE. 1981. Induction and collection of peritoneal exudates macrophages. In Herscowitz BH, Holden HT, Ballanti JA, Ghaffar A (Eds.), Manual of Macrophage Methodology, pp.5-11. Marcel Dekker Incorporation
- Dinkova-Kostova AT, Jenkins SN, Fahey JW, Ye L, Wehage SL, Liby KT, Stephenson KK, Wade KL, Talalay P. 2006. Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. Cancer Lett 240:243-252 https://doi.org/10.1016/j.canlet.2005.09.012
- El-Adawy TA. 2002. Nutritional composition and antinutritional factors of chickpeas (Cicer arietinum L.) undergoing different cooking methods and germination. Plant Foods Hum Nutr 57:83-97 https://doi.org/10.1023/A:1013189620528
- Goupy P, Dufour C, Loonis M, Dangles O. 2003. Quantitative kinetic analysis of hydrogen transfer reactions from dietary polyphenols to the DPPH radical. J Agric Food Chem 51: 615-622 https://doi.org/10.1021/jf025938l
- Hanisch UK. 2002. Microglia as a source and target of cytokines. Glia 40:140-155 https://doi.org/10.1002/glia.10161
- Herr I, Buchler MW. 2010. Dietary constituents of broccoli and other cruciferous vegetables: Implications for prevention and therapy of cancer. Cancer Treat Rev 36:377-383 https://doi.org/10.1016/j.ctrv.2010.01.002
- Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K. 1996. A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol Pharm Bull 19:1518-1520 https://doi.org/10.1248/bpb.19.1518
- Jackaman C, Tomay F, Duong L, Abdol Razak NB, Pixley FJ, Metharom P, Nelson DJ. 2017. Aging and cancer: The role of macrophages and neutrophils. Ageing Res Rev 36:105-116 https://doi.org/10.1016/j.arr.2017.03.008
- Kahlon TS, Chapman MH, Smith GE. 2007. In vitro binding of bile acids by spinach, kale, brussels sprouts, broccoli, mustard greens, green bell pepper, cabbage and collards. Food Chem 100:1531-1536 https://doi.org/10.1016/j.foodchem.2005.12.020
- Keystone EC, Ware CF. 2010. Tumor necrosis factor and anti-tumor necrosis factor therapies. J Rheumatol Suppl 85:27-39 https://doi.org/10.3899/jrheum.091463
- Kim EJ, Kim MH. 2015. Antioxidant activity of solvent fraction from broccoli sprouts cultivated at the plant factory system. Korean J Food Nutr 28:1-8 https://doi.org/10.9799/ksfan.2015.28.1.001
- Kim IS, Han SH, Han KW. 1997. Study on the chemical change of amino acid and vitamin of rapeseed during germination. J Korean Soc Food Sci Nutr 26:1058-1062
- Kim JH, Yi YS, Kim MY, Cho JY. 2017. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J Ginseng Res 41:435-443 https://doi.org/10.1016/j.jgr.2016.08.004
- Kim SL, Kim SK, Park CH. 2004. Introduction and nutritional evaluation of buckwheat sprouts as a new vegetables. Food Res Int 37:319-327 https://doi.org/10.1016/j.foodres.2003.12.008
- Kim YS, Kim JG, Lee YS, Kang IJ. 2005. Comparison of the chemical components of buckwheat seed and sprout. J Korean Soc Food Sci Nutr 34:81-86 https://doi.org/10.3746/jkfn.2005.34.1.081
- Korhonen R, Lahti A, Hamalainen M, Kankaanranta H, Moilanen E. 2002. Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages. Mol Pharmacol 62:698-704 https://doi.org/10.1124/mol.62.3.698
- Kwon YD, Ko ES, Hong SJ, Park SW. 2008. Comparison of sulforaphane and antioxidant contents according to different parts and maturity of broccoli. Korean J Hort Sci Technol 26:344-349
- Lee HS, Park YW. 2005. Antioxidant activity and antibacterial activities from different parts of broccoli extracts under high temperature. J Korean Soc Food Sci Nutr 34:759-764 https://doi.org/10.3746/jkfn.2005.34.6.759
- Lee JJ, Lee YM, Shin HD, Jeong YS, Lee MY. 2007. Effects of vegetable sprout power mixture on lipid metabolism in rats fed high fat diet. J Korean Soc Food Sci Nutr 36: 965-974 https://doi.org/10.3746/jkfn.2007.36.8.965
- Lee YA, Kim HY, Cho EJ. 2005. Comparison of methanol extracts from vegetables on antioxidative effect under in vitro and cell system. J Korean Soc Food Sci Nutr 34:1151-1156 https://doi.org/10.3746/jkfn.2005.34.8.1151
- Marinova D, Ribarova F, Atanassova M. 2005. Total phenolics and total flavonoids in Bulgarian fruits and vegetables. J Univ Chem Technol Metall 40:255-260
- Quigley M, Martinez J, Huang X, Yang Y. 2009. A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood 113:2256-2264 https://doi.org/10.1182/blood-2008-03-148809
- Ravikumar C. 2015. Therapeutic potential of Brassica oleracea (Broccoli) - A review. Int J Drug Dev Res 7:9-10
- Ruhland A, Kima PE. 2009. Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonesis promastigotes. Exp Parasitol 122:28-36 https://doi.org/10.1016/j.exppara.2008.12.010
- Sattar A, Badshah A, Aurangzeb. 1995. Biosynthesis of ascorbic acid in germinating rapeseed cultivars. Plant Foods Hum Nutr 47:63-70 https://doi.org/10.1007/BF01088168
- Schroder K, Hertzog PJ, Ravasi T, Hume DA. 2004. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163-189 https://doi.org/10.1189/jlb.0603252
- Seo JS, Bang BH, Yeo IB. 2001. Effect of improve obesity with sprout raw grains and vegetables. Korean J Food Nutr 14: 150-160
- Smith TF, Johnston RB Jr. 1979. Functions of the spleen in host defense against infection. Am J Pediatr Hematol Oncol 1:355-362
- Sok DE, Kim JH, Kim MR. 2003. Isolation and identification of bioactive organosulfur phytochemicals from solvent extract of broccoli. J Korean Soc Food Sci Nutr 32:315-319 https://doi.org/10.3746/jkfn.2003.32.3.315
- Song MR. 2001. Volatile flavor component of cultivated radish (Raphanus sativus L.) sprout. Korean J Food Nutr 14:20-27
- Stankovic MS. 2011. Total phenolic content, flavonoid concentration and antioxidant activity of Marrubium peregrinum L. extracts. Kragujevac J Sci 33:63-72
- Steinmetz KA, Potter JD. 1996. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96:1027-1039 https://doi.org/10.1016/S0002-8223(96)00273-8
- Takai M, Suido H, Tanaka T, Kotani M, Fujita A, Takeuchi A, Makino T, Sumikawa K, Origasa H, Tsuji K, Nakashima M. 2003. LDL-cholesterol-lowering effects of a mixed green vegetable and fruit beverage containing broccoli and cabbage in hypercholesterolemic subjects. Rinsho Byori 51:1073-1083
- Tanaka T, Narazaki M, Kishimoto T. 2016. Immunotherapeutic implications of IL-6 blockade for cytokine storm. Immunotherapy 8:959-970 https://doi.org/10.2217/imt-2016-0020
- Taniguchi I, Kobayashi-Hattori K, Tenmyo C, Kamei T, Uda Y, Sugita-Konishi Y, Oishi Y, Takita T. 2006. Effect of Japanese radish (Raphaus sativus) sprout (Kaiware-daikon) on carbohydrate and lipid metabolism in normal and streptozotocin-induced diabetic rats. Phytother Res 20:274-278 https://doi.org/10.1002/ptr.1851
- Tian Q, Rosselot RA, Schwartz SJ. 2005. Quantitative determination of intact glucosinolates in broccoli, broccoli sprouts, brussels sprouts, and cauliflower by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal Biochem 343:93-99 https://doi.org/10.1016/j.ab.2005.04.045
- Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, Kuo JS, Hong JS, Jeng KCG. 2002. Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur J Neurosci 16:2103-2112 https://doi.org/10.1046/j.1460-9568.2002.02290.x