Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Isolation of Constituents with Nitric Oxide Synthase Inhibition Activity from Phryma leptostachya var. asiatica

  • Kim, Donghwa (College of Pharmacy, Seoul National University) ;
  • Lee, Sang Kook (College of Pharmacy, Seoul National University) ;
  • Park, Kyoung-Sik (College of Oriental Medicine, Sangji University) ;
  • Kwon, Na-Yun (Department of Pharmaceutical Engineering, Sangji University) ;
  • Park, Hee-Juhn (Department of Pharmaceutical Engineering, Sangji University)
  • Received : 2018.08.15
  • Accepted : 2018.09.17
  • Published : 2019.03.31
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Abstract

Phytochemical studies were performed to identify the active principles of Phryma leptostachya var. asiatica (Phyrymaceae) for anti-inflammation. The anti-inflammatory activity was assessed by measuring the inhibition rate on nitric oxide (NO) formation in lipopolysaccharide (LPS)-activated macrophage 264.7 cells. Of the five compounds including ursolic acid, phrymarolin I, harpagide, haedoxancoside A, and acteoside isolated from this plant, ursolic acid showed the most prominent inhibition of NO formation. Therefore, ursolic acid may be the anti-inflammatory principle of Phryma leptostachya var. asiatica.

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References

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