International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
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Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression

  • Kim, Yeon (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Park, Joo-Yeon (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Park, Hyun-Joo (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Kim, Mi-Kyoung (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Kim, Yong-Il (Department of Orthodontics, School of Dentistry, Pusan National University) ;
  • Bae, Soo-Kyung (Department of Dental Pharmacology, School of Dentistry, Pusan National University) ;
  • Kim, Hyung Joon (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Bae, Moon-Kyoung (Department of Oral Physiology, School of Dentistry, Pusan National University)
  • Received : 2018.12.10
  • Accepted : 2019.02.07
  • Published : 2019.03.31
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Abstract

Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.

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References

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