The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Review of Recent Clinical Research about Banhasasim-tang Combined with Conventional Therapy on Atrophic Gastritis

위축성 위염에 대한 반하사심탕과 표준치료 병용요법의 최신 연구 동향

  • Lee, Ga-young (Dept. of Korean Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Ahn, Su-bin (Dept. of Korean Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Jeong, Min-jeong (Dept. of Pediatrics, College of Korean Medicine, Woo-Suk University) ;
  • Jang, In-soo (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University)
  • 이가영 (우석대학교 한의과대학 한의학과) ;
  • 안수빈 (우석대학교 한의과대학 한의학과) ;
  • 정민정 (우석대학교 한의과대학 소아과학교실) ;
  • 장인수 (우석대학교 한의과대학 한방내과학교실)
  • Received : 2019.12.06
  • Accepted : 2020.01.03
  • Published : 2019.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The purpose of this study was to investigate the effect of combined therapy with Banhasasim-tang and conventional treatment for atrophic Gastritis. Methods: The study collected data of clinical studies of combined therapy with Banhasasim-tang and conventional treatment for atrophic gastritis. Electronic databases were used, including PubMed, Cochrane, CNKI, Wanfang, CINII, J-stage, NDSL, and OASIS. The main search terms included such as "Atrophic Gastritis", "Banhasasim-tang", "BanXia Xiexin Tang". This study only included randomized controlled trials (RCTs) that adopted combined therapy with Banhasasim-tang and conventional treatment for atrophic gastritis. Results: A total of 18 RCTs were selected. They all adopted combined therapy with Banhasasim-tang and conventional treatment for atrophic gastritis. In all the studies, the intervention group significantly improved the score of effective rate, and in the 8 studies, Hp negative conversion rate was significantly improved when Banhasasim-tang was taken. Conclusion: Through the analysis of 18 RCTs, we found Banhasasim-tang combined with conventional therapy were more effective in the positive performance of atrophic gastritis than conventional therapy single contribution. However, due to the low quality of the selected studies and the lack of endoscopy, biopsy, follow-up observation, so there is a slight insufficient to prove its conclusion. Therefore, we hope that more systematic and diverse clinical studies will be conducted.

Keywords

References

  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394-424. doi:10.3322/caac.21492.
  2. Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2016, Ministry of Health and Welfare, 2018. Available at http://www.ncc.re.kr/main.ncc?uri=english/sub04_Statistics [Accessed: Dec 06 2019]
  3. Sipponen P, Kekki M, Haapakoski J, Ihamaki T, Siurala M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of crosssectional data. Int J Cancer 1985;35(2):173-7. https://doi.org/10.1002/ijc.2910350206
  4. Di Gregorio C, Morandi P, Fante R, De Gaetani C. Gastric dysplasia: a follow-up study. Am J Gastroenterol 1993;88(10):1714-9.
  5. Kim N, Park YS, Cho SI, Lee HS, Choe G, Kim IW, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. Helicobacter 2008;13(4):245-55. doi:10.1111/j.1523-5378.2008.00604.x
  6. de Vries AC, van Grieken NC, Looman CW, Casparie MK, de Vries E, Meijer GA, et al. Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands. Gastroenterology 2008;134(4):945-52. doi:10.1053/j.gastro.2008.01.071
  7. Kim N, Park RY, Cho SI, Lim SH, Lee KH, Lee W, et al. Helicobacter pylori infection and development of gastric cancer in Korea: long-term follow-up. J Clin Gastroenterol 2008;42(5):448-54. doi:10.1097/MCG.0b013e318046eac3
  8. Rugge M, Correa P, Dixon MF, Fiocca R, Hattori T, Lechago J, et al. Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading. Aliment Pharmacol Ther 2002;16(7):1249-59. doi:10.1046/j.1365-2036.2002.01301.x
  9. Cassaro M, Rugge M, Gutierrez O, Leandro G, Graham DY, Genta RM. Topographic patterns of intestinal metaplasia and gastric cancer. Am J Gastroenterol 2000;95(6):1431-8. doi:10.1111/j.1572-0241.2000.02074.x
  10. Adamu MA, Weck MN, Gao L, Brenner H. Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies. Eur J Epidemiol 2010;25(7):439-48. doi:10.1007/s10654-010-9482-0
  11. Asaka M, Kato M, Kudo M, Katagiri M, Nishikawa K, Koshiyama H, et al. Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging:studies in asymptomatic Japanese adults. Helicobacter 1996;1(1):52-6. doi:10.1111/j.1523-5378.1996.tb00008.x
  12. Aoki K, Kihaile PE, Wenyuan Z, Xianghang Z, Castro M, Disla M, et al. Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic. Ann Epidemiol 2005;15(8):598-606. doi:10.1016/j.annepidem.2004.11.002
  13. Fang JY, Liu WZ, Li ZS, Du YQ, Ji XL, Ge ZZ, et al. Consensus on standard management of choronic gastritis in China. Chinese J Gastroenterology 2013;18(1):24-36. https://doi.org/10.3969/j.issn.1008-7125.2013.01.007
  14. Moon J, Ahn G, Kim S, Park J, Kim D, Choi D, et al. Shanghanlun Jeonghae. Seoul: Publication Haneui Munhwasa; 2010, p. 317-9.
  15. Kook YB, Kim SC, Park SD, Park SK, Seo BI, Seo YB, et al. Formula Study. Seoul: Publication Younglimsa; 2006, p. 162-4.
  16. Naito T, Itoh H, Yasunaga F, Takeyama M. Hange-shashin-to raises levels of somatostatin, motilin, and gastrin in the plasma of healthy subjects. Biol Pharm Bull 2002;25(3):327-31. doi:10.1248/bpb.25.327
  17. Wang XN, Li X. Clinical Observation of Banxia Xiexin Decoction combined with Rebamipide in the Treatment of Chronic Atrophic Gastritis. J North Pharmacy 2019;16(2):77.
  18. Liu J. Effect of Modified Banxia Xiexin Decoction in the Treatment of Chronic Atrophic Gastritis. J Practical Traditional Chinese Medicine 2019;35(7):837-8.
  19. Li J, Rao L. Evaluation of Modified Banxia Xiexin Decoction Combined with Triple Therapy in the Treatment of Helicobacter Pylori-related Atrophic Gastritis. J Clinical Medical 2019;6(18):167-70.
  20. Wang XM, Yan G, Liu C. Effects of Banxia Xiexin Decoction on Chronic Atrophic Gastritis of Spleen-stomach Damp-heat Type and Serum Inflammatory Index and Immune Function. World Chinese Medicine 2019;14(2):412-6.
  21. Xu H. Clinical effect of Banxia Xiexin Decoction on chronic atrophic gastritis. Chinese Health Vision 2019;9:15.
  22. Wang W. Observation of Clinical Effect of Modified Banxia Xiexin Decoction Combined with Triple Therapy on Helicobacter Pylori-related Atrophic Gastritis. Modern J Integrated Traditional Chinese and Western Medicine 2018;27(28):3153-5. doi:10.3969/j.issn.1008-8849.2018.28.023
  23. Wu T. Effect and safety of Banxia Xiexin Decoction combined with western medicine in the treatment of chronic atrophic gastritis. Chinese and Foreign Medical Research 2018; 16(35):33-4. doi:10.14033/j.cnki.cfmr.2018.35.015
  24. Zhang S. Analysis of clinical effect of modified Banxia Xiexin decoction in the treatment of chronic atrophic gastritis. Chin J Mod Drug Appl 2018;12(4):73-4.
  25. You H. Clinical application of Banxia Xiexin Decoction combined with western medicine anti-HP in the treatment of atrophic gastritis. World Latest Medicine Information 2018;18(96):135. doi:10.19613/j.cnki.1671-3141.2018.96.102
  26. Yang C, Wang P. Observation of Clinical effect and safety of Modified Banxia Xiexin Decoction combined with triple therapy in the treatment of H. pylori-related atrophic gastritis. Our Health 2018;11:42.
  27. Chen W. Clinical Observation of Banxia Xiexin Tang Combined with Triple Therapy for Chronic Atrophic Gastritis. J New Chinese Medicine 2018;50(6):93-5.
  28. Yang Z. Clinical Observation of Banxia Xiexin Decoction in Treating Chronic Atrophic Gastritis. Healthmust-Readmagazine 2018;3:182.
  29. Jiang G. Observation of clinical effect of Modified Banxia Xiexin Decoction on chronic atrophic gastritis. China Health Care &Nutrition 2018;28(1)144-5.
  30. Zhu T. Analysis of the clinical effect of Pinellia Heart-Draining Decoction in the treatment of chronic atrophic gastritis. For all Health 2018;12(5):2-3.
  31. Lu X. Clinical effect of Banxia Xiexin Decoction on chronic atrophic gastritis. Research of Integrated Traditional Chinese and Western Medicine 2017; 9(6):295-6. doi:10.3969/j.issn.1674-4616.2017.06.006
  32. Cui Z. Clinical Observation of Modified Banxia Xiexin Decoction in the Treatment of Chronic Atrophic Gastritis. Nei Mongol J Traditional Chinese Medicine 2017;4:32. doi:10.16040/j.cnki.cn15-1101.2017.04.032
  33. Xu G. Clinical Effect of Modified Banxia Xiexin Decoction on Chronic Atrophic Gastritis. China Prac Med 2017;12(5):143-5. doi:10.14163/j.cnki.11-5547/r.2017.05.072
  34. Fang J. Clinical effect observation of Banxia Xiexin decoction in treating chronic atrophic gastritis. Traditional Chinese medicine 2017;29 :107-8. doi:10.19347/j.cnki.2096-1413.201729052
  35. Lee S. The roles of osteopontin on gastric and hepatic carcinogenesis in mouse model (Doctoral dissertation). Seoul National University 2017 Retrieved from Semantic Scholar database.
  36. Kim J. Atrophy and intestinal metaplasia of the stomach. Korean Society of Gastrointestinal Endoscopy 2013;50:29-31.