The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

The Effectiveness of Pyungjinsujeom-san on Chest Pain: A Retrospective Study

흉통에 대한 평진수점산의 효과 : 후향적 연구

  • Shin, Hee-yeon (Dept. of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Choi, Jeong-woo (Dept. of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Ha-ri (Dept. of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Sang-hwa (Stroke and Neurological Disorders Center, Kyung Hee University Korean Medicine Hospital at Gangdong) ;
  • Yang, Seung-bo (Stroke and Neurological Disorders Center, Kyung Hee University Korean Medicine Hospital at Gangdong) ;
  • Cho, Seung-yeon (Dept. of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Seong-uk (Dept. of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ko, Chang-nam (Dept. of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Jung-mi (Dept. of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 신희연 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 최정우 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 김하리 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 이상화 (강동경희대학교한방병원 뇌신경센터 한방내과) ;
  • 양승보 (강동경희대학교한방병원 뇌신경센터 한방내과) ;
  • 조승연 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박성욱 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 고창남 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박정미 (경희대학교 대학원 한방순환신경내과학교실)
  • Received : 2019.08.30
  • Accepted : 2019.11.19
  • Published : 2019.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: Chest pain presents diagnostic and therapeutic challenges because of its various etiologies. Many patients have chest pain from unknown causes and persistent chest pain in spite of standard treatment. The purpose of this study was to investigate the effectiveness of a Korean herbal medicine called Pyungjinsujeom-san (PSS) in relieving chest pain. Methods: We reviewed the electronic medical records of patients who visited the Korean Medical Clinic of Cardiology at Kyunghee University Hospital at Gangdong from January 2009 to July 2019, with the chief complaint of chest pain and who were treated with PSS. The mean severity of chest pain measured on the Numerical Rating Scale was compared before and after the administration of PSS. Results: The mean severity of chest pain of 20 patients decreased significantly from 6.80±1.61 to 1.35±0.9 after taking PSS (p<0.001). Most patients had symptoms of phlegm and food retention, including indigestion, postprandial fullness, and epigastric pain.Conclusions: These results suggest that PSS may be effective in relieving chest pain from various causes, particularly in patients with symptoms of phlegm and food retention.

Keywords

References

  1. Ruigomez A, Rodriguez LAG, Wallander MA, Johansson S, Jones R. Chest pain in general practice: incidence, comorbidity and mortality. Fam Pract 2006;23(2):167-74. https://doi.org/10.1093/fampra/cmi124
  2. Hoorweg BB, Willemsen RT, Cleef LE, Boogaert T, Buntinx F, Glatz J, et al. Frequency of chest pain in primary care, diagnostic tests performed and final diagnoses. Heart 2017;103(21):1727-32. https://doi.org/10.1136/heartjnl-2016-310905
  3. Frieling T. Non-Cardiac Chest Pain. Visc Med 2018;34(2):92-6. https://doi.org/10.1159/000486440
  4. Arnold SV, Jang JS, Tang F, Graham G, Cohen DJ, Spertus JA. Prediction of residual angina after percutaneous coronary intervention. Eur Hear journal Qual care Clin outcomes 2015;1(1):23-30. https://doi.org/10.1093/ehjqcco/qcv010
  5. Bass C, Mayou R. Chest pain. Management of chest pain. Types of chest pain. Br Med J 2002;325(7364):588-91. https://doi.org/10.1136/bmj.325.7364.588
  6. Glombiewski JA, Rief W, Bosner S, Keller H, Martin A, Donner-Banzhoff N. The course of nonspecific chest pain in primary care: symptom persistence and health care usage. Arch Intern Med 2010;170(3):251-5. https://doi.org/10.1001/archinternmed.2009.474
  7. 전국한의과대학 심계내과학 교수협의회. 한방순환.신경내과학 I. 서울: 우리의학서적; 2016, p. 119-36.
  8. 허준. 윤석희, 김형준, 정행규, 백근기, 대한형상의학회. (對譯東醫寶鑑)동의보감. 경남: 동의보감출판사; 2005.
  9. Chang IG, Park SI. Experimental Studies on Efficacy of Pyungjinsujeomsan. KHM 1987;3(4):510-22.
  10. Jang IS, Ko CN, Lee I, Park JM, Kim SH, Kim SW. Effect of Cardiotonic $Pills^{(R)}$ on Chest Pain and Discomfort: A Multi-center Double-blind Randomized Controlled Trial. J Korean Oriental Med 2005;26(2):95-104.
  11. Lee DK, Hwang SH, Koh JY, Son AH, Shin HS. A Case Report of Two Nongastroesophageal Idiopathic Atypical Chest Pain PatientsTreated by Gwaruhaebackbackju-tang and Gwaruhaebackbanha-tang. J Int Korean Med 2017;38(3):383-91. https://doi.org/10.22246/jikm.2017.38.3.383
  12. Ha YK, Noh HS, Yi CS, Park SW, Hong SC, Choi DJ. A Case Report of an Ischemic Heart Disease Patient with Chest Discomfort and a Headache. J Int Korean Med 2017;38(2):276-83. https://doi.org/10.22246/jikm.2017.38.2.276
  13. Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romundstad L, Breivi Hals EK, et al. Assessment of pain. Br J Anaesth 2008;101(1):17-24. https://doi.org/10.1093/bja/aen103
  14. Park YJ, Lim JS, Park YB. Development of a valid and reliable food retention questionnaire. Eur J Integr Med 2013;5(5):432-7. https://doi.org/10.1016/j.eujim.2013.06.002
  15. Park JS, Yang DH, Kim MY, Lee SC, Park YJ. Development of Questionnaire for Damum Patternization. The Journal of The Korea Institute of Oriental Medical Diagnostics 2006;10(1):64-77.
  16. Okitsu R, Iwasaki K, Monma Y, Takayama S, Kaneko S, Shen G, et al. Development of aquestionnaire for the diagnosis of Qi-stagnation. Complement Ther Med 2012;20(4):207-17. https://doi.org/10.1016/j.ctim.2011.12.005
  17. Yang DH, Park YJ, Park YB, Lee SC. Development of questionnaires for blood stasis pattern. J Korean Inst Orient Med Diag 2006;10(1):141-52.
  18. 윤용갑. 동의방제와 처방해설. 서울: 의성당;2002, p. 513.
  19. Nam SJ, Park SC, Lee SJ. Extraesophageal Manifestations of Gastroesophageal Reflux Disease. Korean J Med 2016;91(3):257-63. https://doi.org/10.3904/kjm.2016.91.3.257
  20. Hershcovici T, Achem SR, Jha LK, Fass R. Systematic review: the treatment of noncardiac chest pain. Aliment Pharmacol Ther 2012;35(1):5-14. https://doi.org/10.1111/j.1365-2036.2011.04904.x
  21. Dickman R, Emmons S, Cui H, Sewell J, Hernadez D, Esquivel RF, et al. The effect of a therapeutic trial of high-dose rabeprazole on symptom response of patients with non-cardiac chest pain: a randomized, double-blind, placebo -controlled, crossover trial. Aliment Pharmacol Ther 2005;22(6):547-55. https://doi.org/10.1111/j.1365-2036.2005.02620.x
  22. Igaz I, Simonyi G, Balogh S, Szathmari M. Adverse effects of long-term proton-pump inhibitor therapy on adults. Orv Hetil 2018;159(19):735-40. https://doi.org/10.1556/650.2018.31057
  23. Cayley WEJ. Diagnosing the cause of chest pain. Am Fam Physician 2005;72(10):2012-21.
  24. Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002;97(11):2744-9. https://doi.org/10.1016/S0002-9270(02)05480-1
  25. Kwak MA, Seo BI, Byun JS. Antibacterial Activity of Combination use of Jengjengamiygin-tagn and Clarithromycin against Helicobacter pylori. Kor J Herboolgy 2004;19(3):75-83.
  26. Fleet RP, Dupuis G, Marchand A, Burelle D, Arsenault A, Beitman BD. Panic disorder in emergency department chest pain patients: prevalence, comorbidity, suicidal ideation and physical recognition. A J Med 1996;101(4):371-80. https://doi.org/10.1016/S0002-9343(96)00224-0
  27. Huffman JC, Pollack MH. Predicting panic disorder among patients with chest pain: an analysis of the literature. Psychosomatics 2003;44(3):222-36. https://doi.org/10.1176/appi.psy.44.3.222
  28. Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effect in patients with noncardiac chest pain: a 24-week randomized controlled trial. Depress Anxiety 2013;30(7):670-8. https://doi.org/10.1002/da.22106
  29. Sarkar S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000;356(9236):1154-9. https://doi.org/10.1016/S0140-6736(00)02758-6
  30. Ku BS, Lee WC. Expeperiment Study on the Anti-Stress of Walgukhwan, Walgukhwan+Ejintang and Walgukhwan+Samultang. J Korean Med 1996;17(1):146-70.
  31. Marinescu MA, Loffler AI, Ouellette M, Smith L, Kramer CM, Bourque JM. Coronary Microvascular Dysfunction, Microvascular Angina, and Treatment Strategies. JACC Cardiovasc Imaging 2015;8(2):210-20. https://doi.org/10.1016/j.jcmg.2014.12.008
  32. Kim DH. A Study on the Effect of Soojeomsanand each herbs on Thrombosis and Elevated Blood Viscosity. J Issue KH Univ 1990;13(1):261-76.
  33. Fass R, Achem SR. Noncardiac chest pain: epidemiology, natural course and pathogenesis. J Neurogastroenterol Motil 2011;17(2):110-23. https://doi.org/10.5056/jnm.2011.17.2.110
  34. Lee DH, Lee YE, Lee BY, Kim YJ, Cho SY, Park SU, et al. Analgesic Effect of a Traditional Korean Medicine Yang Eui Gongjin-dan on Severe Pain: A Retrospective Study. J Int Korean Med 2015;36(3):265-75.