Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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The Beneficial Effect of Avocado on Skin Inflammation in a Mouse Model of AD-like Skin Lesions

  • Myung, Noh-Yil (Department of Oriental Medicine and Healthcare, Wonkwang Digital University) ;
  • Kim, Su-Jin (Department of Biotechnology and Convergence, Daegu Haany University)
  • Received : 2019.10.11
  • Accepted : 2019.12.18
  • Published : 2019.12.31
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Abstract

Avocado, superfood, contains a variety of essential nutrients and phytochemicals. The purpose of this study was to explore whether avocado could modulate skin inflammation in vivo. We elucidated the pharmacological effects of avocado on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice. Additionally, we investigated the anti-inflammatory activity of avocado and its underlying mechanism including its effect on the expression levels of inflammatory-related genes and nuclear factor-κB (NF-κB) in DNCB-induced AD-like skin lesions. The findings of this study demonstrate that avocado attenuated AD-clinical symptoms including itching, eczematous, erythema and dryness and histamine levels in mice. Moreover, avocado suppressed both inflammatory cytokines expression as well as NF-κB and caspase-1 activation in AD-like skin lesions in mice. Taken together, these results demonstrate that avocado may be a potential candidate for treating skin inflammatory diseases like AD.

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References

  1. Allam, J.P. and N. Novak. 2006. The pathophysiology of atopic eczema. Clin. Exp. Dermatol. 31:89-93. https://doi.org/10.1111/j.1365-2230.2005.01980.x
  2. Au, R.Y., T.K. Al-Talib, A.Y. Au, P.V. Phan and C.G. Frondoza. 2007. Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. Osteoarthr. Cartilage 15:1249-1255. https://doi.org/10.1016/j.joca.2007.07.009
  3. Berke, R., A. Singh and M. Guralnick. 2012. Atopic dermatitis: an overview. Am. Fam. Physician 86:35-42.
  4. Bhuyan, D.J., QV. Vuong, A.C. Chalmers, I.A. Van Altena, M.C. Bowyer and C.J. Scarlett. 2016. Investigation of phytochemicals and antioxidant capacity of selected Eucalyptus species using conventional extraction. Chem. Pap. 70:567-575. https://doi.org/10.1515/chempap-2015-0237
  5. Bieber, T. 2008. Atopic dermatitis. N. Engl. J. Med. 358:1483-1494. https://doi.org/10.1056/NEJMra074081
  6. Bouchier-Hayes, L. and S.J. Martin. 2004. CARDINAL roles in apoptosis and NFkappaB activation. Vitam. Horm. 67:133-147. https://doi.org/10.1016/S0083-6729(04)67008-7
  7. Brenninkmeijer, E.E., P.I. Spuls, C.M. Legierse, R. Lindeboom, J.H. Smitt and J.D. Bos. 2008. Clinical differences between atopic and atopiform dermatitis. J. Am. Acad. Dermatol. 58:407-414. https://doi.org/10.1016/j.jaad.2007.12.002
  8. Bunikowski, R., K. Gerhold, M. Brautigam, E. Hamelmann, H. Renz and U. Wahn. 2001. Effect of low-dose cyclosporin a microemulsion on disease severity, interleukin-6, interleukin-8 and tumor necrosis factor alpha production in severe pediatric atopic dermatitis. Int. Arch. Allergy Immunol. 125:344-348. https://doi.org/10.1159/000053836
  9. Das, A. and S. Panda. 2017. Use of topical corticosteroids in dermatology: an evidence-based approach. Indian J. Dermatol. 62:237-250.
  10. Fedenko, E.S., O.G. Elisyutina, T.M. Filimonova, M.N. Boldyreva, O.V. Burmenskaya, O.Y. Rebrova, A.A. Yarilin and R.M. Khaitov. 2011. Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals. Self Nonself. 2:120-124. https://doi.org/10.4161/self.2.2.16939
  11. Gomez, G. 2019. Current strategies to inhibit high affinity fc${\varepsilon}$ ri-mediated signaling for the treatment of allergic disease. Front Immunol. 10:175-185. https://doi.org/10.3389/fimmu.2019.00175
  12. Gold, M.S. and A.S. Kemp. 2005. Atopic disease in childhood. Med. J. Aust. 182:298-304. https://doi.org/10.5694/j.1326-5377.2005.tb06707.x
  13. Gilmore, T.D. and M.R. Garbati. 2011. Inhibition of NF-${\kappa}$B signaling as a strategy in disease therapy. Curr. Top. Microbiol. Immunol. 349:245-263.
  14. Hanifin, J.M., M. Thurston, M. Omoto, R. Cherill, S.J. Tofte and M. Graeber. 2001. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp. Dermatol. 10:11-18. https://doi.org/10.1034/j.1600-0625.2001.100102.x
  15. Hawiger, J. 2001. Innate immunity and inflammation: a transcriptional paradigm. Immunol. Res. 23:99-109. https://doi.org/10.1385/IR:23:2-3:099
  16. Imaizumi, A., T. Kawakami, F. Murakami, Y. Soma and M. Mizoguchi. 2003. Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): Changes in blood histamine and tryptase levels. J. Dermatol. Sci. 33:23-29. https://doi.org/10.1016/S0923-1811(03)00132-4
  17. Kim, S.J., M.C. Kim, J.Y. Um and S.H. Hong. 2010. The beneficial effect of vanillic acid on ulcerative colitis. Molecules 15:7208-7217. https://doi.org/10.3390/molecules15107208
  18. Kim, S.J., J.Y. Kee, I.Y. Choi, M.C. Kim, D.S. Kim, Y.D. Jeon, S.G. Kim, B.S. Kim, H.J. Jung, H.M. Kim, S.H. Hong and J.Y. Um. 2011. Insamhodo-tang, a traditional Korean medicine, regulates mast cell-mediated allergic inflammation in vivo and in vitro. J. Ethnopharmacol. 134:339-347. https://doi.org/10.1016/j.jep.2010.12.023
  19. Lamkanfi, M., M. Kalai, X. Saelens, W. Declercq and P. Vandenabeele. 2004. Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity. J. Biol. Chem. 279:24785-24793. https://doi.org/10.1074/jbc.M400985200
  20. Lee, J.W. and Y.J. Kang. 2018. Anti-inflammatory effects of Abeliophyllum distichum flower extract and associated MAPKs and NF-${\kappa}$B pathway in raw264.7 cells. Korean J. Plant Res. 31:202-210. https://doi.org/10.7732/KJPR.2018.31.3.202
  21. Lee, K.S., E.S. Jeong, S.H Heo, J.H. Seo, D.G. Jeong and Y.K. Choi. 2010. A novel model for human atopic dermatitis: application of repeated DNCB patch in BALB/c mice, in comparison with NC/Nga mice. Lab. Anim. Res. 26:95-102. https://doi.org/10.5625/lar.2010.26.1.95
  22. Leung, D.Y. and T. Bieber. 2003. Atopic dermatitis. Lancet 361:151-160. https://doi.org/10.1016/S0140-6736(03)12193-9
  23. Lu, Q.Y., J.R Arteaga, Q. Zhang, S. Huerta, V.L. Go and D. Heber. 2005. Inhibition of prostate cancer cell growth by an avocado extract: Role of lipid-soluble bioactive substances. J. Nutr. Biochem. 16:23-30. https://doi.org/10.1016/j.jnutbio.2004.08.003
  24. Minami, K. and C.A. Kamei. 2004. Chronic model for evaluating the itching associated with allergic conjunctivitis in rats. Int. Immunopharmacol. 4:101-108. https://doi.org/10.1016/j.intimp.2003.10.013
  25. Nomura, I., B. Gao, M. Boguniewicz, M.A. Darst, J.B. Travers and D.Y. Leung. 2003. Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J. Allergy Clin. Immunol. 112:1195-1202. https://doi.org/10.1016/j.jaci.2003.08.049
  26. Pahua-Ramos, M.E., A. Ortiz-Moreno, G. Chamorro-Cevallos, M.D. Hernandez-Navarro, L. Garduno-Siciliano, H. Necoechea-Mondragon and M. Hernandez-Ortega. 2012. Hypolipidemic effect of avocado (Persea americana Mill) seed in a hypercholesterolemic mouse model. Plant Foods Hum. Nutr. 67:10-16. https://doi.org/10.1007/s11130-012-0280-6
  27. Rosenblat, G., S. Meretski, J. Segal, M.Tarshis, A. Schroeder, A. Zanin-Zhorov, G. Lion, A. Ingber and M. Hochberg. 2011. Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. Arch. Dermatol. Res. 303:239-246. https://doi.org/10.1007/s00403-010-1088-6
  28. Saeki, H., M. Furue, F. Furukawa, M. Hide, M. Ohtsuki, I. Katayama, R. Sasaki, H. Suto and K. Takehara. 2009. Guidelines for management of atopic dermatitis. J. Dermatol. 36:563-577. https://doi.org/10.1111/j.1346-8138.2009.00706.x
  29. Shin, W.B., X. Dong, Y.S. Kim, J.S. Park, S.J. Kim, E.A. Go, E.K. Kim and P.J. Park. 2019. Anti-inflammatory effects of Batillaria multiformis water extracts via nf-${\kappa}$b and mapk signaling pathways in lps-induced raw 264.7 cells. Adv. Exp. Med. Biol. 1155:1001-1014. https://doi.org/10.1007/978-981-13-8023-5_83
  30. Shiohara, T., J. Hayakawa and Y. Mizukawa. 2004. Animal models for atopic dermatitis: are they relevant to human disease? J. Dermatol. Sci. 36:1-9. https://doi.org/10.1016/j.jdermsci.2004.02.013
  31. Siegmund, B., H.A. Lehr, G. Fantuzzi and C.A. Dinarello. 2001. IL-1 betaconverting enzyme (caspase-1) in intestinal inflammation. Porc. Natl. Acad. Sci. U.S.A. 98:13249-13254. https://doi.org/10.1073/pnas.231473998
  32. Sugimoto, M., I. Arai, N. Futaki, Y. Hashimoto, T. Sakurai, Y. Honma and S. Nakaike. 2006. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Ngamice. Exp. Dermatol. 15:875-882. https://doi.org/10.1111/j.1600-0625.2006.00480.x
  33. Tegeder, I., J. Pfeilschifter and G. Geisslinger. 2001. Cyclooxygenase- independent actions of cyclooxygenase inhibitors. FASEB J. 15:2057-2072. https://doi.org/10.1096/fj.01-0390rev
  34. Trefzer, U., M. Hofmann, W. Sterry and K. Asadullah. 2003. Cytokine and anti-cytokine therapy in dermatology. Expert opin. Biol Ther. 3:733-743. https://doi.org/10.1517/14712598.3.5.733
  35. Wang, X., H.Y. Wang and E.F. Bryan. 2005. Dysregulation of receptor interacting protein‐2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease. J. Neurosci. 25:11645-11654. https://doi.org/10.1523/JNEUROSCI.4181-05.2005
  36. Wong, C.K., C.Y. Ho, F.W. Ko, C.H. Chan, A.S. Ho, D.S. Hui and C.W. Lam. 2001. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin. Exp. Immunol. 125:177-183. https://doi.org/10.1046/j.1365-2249.2001.01602.x