Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Water Extract of Taraxaci Radix Improves Rheumatoid Arthritis Induced by Type-II Collagen in Animal Models

민들레 뿌리 물 추출물의 류마티스 관절염 동물 모델에 대한 개선 효과

  • Nho, Jong Hyun (National Development Institute of Korean Medicine) ;
  • Lee, Hyun Joo (National Development Institute of Korean Medicine) ;
  • Jang, Ji Hun (National Development Institute of Korean Medicine) ;
  • Yang, Beo Dul (National Development Institute of Korean Medicine) ;
  • Kim, A Hyeon (National Development Institute of Korean Medicine) ;
  • Woo, Kyeong Wan (National Development Institute of Korean Medicine) ;
  • Hwang, Tae Yeon (National Development Institute of Korean Medicine) ;
  • Seo, Jae Wan (National Development Institute of Korean Medicine) ;
  • Cho, Hyun Woo (National Development Institute of Korean Medicine) ;
  • Jung, Ho Kyung (National Development Institute of Korean Medicine)
  • Received : 2018.11.19
  • Accepted : 2018.12.26
  • Published : 2019.02.28
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Abstract

Background: Taraxacum platycarpum has been used in traditional medicine in Korea to treat intoxication and edema and as a diuretic. According to previous reports, it has anti-cancer, anti-gastritis, and anti-inflammation effects. However, the improvement effect of T. platycarpum on rheumatoid arthritis has not been investigated. The anti-oxidative and anti-inflammation effects of the aerial parts of T. platycarpum are different from those of its subterranean parts. Thus, we evaluated the effect of the water extracts of Taraxaci radix (WTR) on type II collagen-induced rheumatoid arthritis (CIA) in animal models. Methods and Results: Rheumatoid arthritis was induced by type II collagen. WTR (100 mg/kg and 500 mg/kg) was administered to the animal models. Methotrexate was used as the positive control. The levels of interleukin-6, TNF-alpha, and type II collagen IgG in the animals were measured by using enzyme-linked immunosorbent assay. Treatment with 500 mg/kg WTR decreased the serum levels of interleukin-6, TNF-alpha, and collagen IgG in the CIA models. Moreover, treatment with WTR diminished the arthritisinduced swelling of the hind legs and monocyte infiltration in the bloodvessels of the animal models. Conclusions: These results indicate that WTR has the potential to improve rheumatoid arthritis by reducing the levels of inflammatory cytokines such as interleukin-6 and TNF-alpha. However, further experiments are required to elucidate the influence of WTR on signal transduction in vitro and in vivo.

Keywords

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Fig. 1. Improvement effect of WTR on type II collagen-induced swelling and erythema of hind legs.

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Fig. 2. Improvement effect of WTR on type II collagen IgG level and infiltration of inflammatory cell in synovial membrane.

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Fig. 3. WTR administration decreased the serum level of IL-6 and TNF-alpha on type II collagen-induced rheumatoid arthritis models.

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