대한후두음성언어의학회지 (Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics)

  • 제30권2호
  • /
  • Pages.124-127
  • /
  • 2019
  • /
  • 2508-268X(pISSN)
  • /
  • 2508-5603(eISSN)
대한후두음성언어의학회 (The Korean Society of Laryngology, Phoniatrics and Logopedics. )
권호 표지
DOI QR코드

DOI QR Code

기본섬유아세포 성장인자와 콜라겐 골격으로 치료한 난치성 성대 반흔 1예

A Case of Surgical Treatment of Intractable Vocal Fold Scar Using Basic Fibroblast Growth Factor and Collagen Scaffold

  • 강현택 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실) ;
  • 김효준 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실) ;
  • 박기남 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실) ;
  • 이승원 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실)
  • Kang, Hyun Tag (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kim, Hyo Jun (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Park, Ki Nam (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Lee, Seung Won (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital)
  • 투고 : 2019.01.21
  • 심사 : 2019.07.09
  • 발행 : 2019.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Vocal fold scarring is an intractable phonosurgical condition. The number of patients with vocal fold scars is increasing with the aging of society and with the increasing application of laryngeal microsurgery. Many methods are available to treat these, including voice therapy, stem cells, regenerative scaffolds, and growth factors. However, no standard treatment strategy has yet been established, and novel techniques are required. Basic fibroblast growth factor has been shown to be effective for the treatment of mild chronic vocal fold scarring. The combined use of basic fibroblast growth factor and regenerative scaffolds is currently under investigation. Here, we report a female patient in whom vocal fold scarring developed after two laryngeal microsurgeries. We performed laryngeal microsurgery to remove the scar tissue and used basic fibroblast growth factor and a collagen scaffold to promote healing. The patient's voice quality was greatly increased, and she was content with her voice after 2 years of follow-up. This is the first report of this methodology in Korea and is presented along with a review of the literature.

키워드

참고문헌

  1. Ban MJ, Park JH, Kim JW, Park KN, Lee JY, Kim HK, et al. The efficacy of fibroblast growth factor for the treatment of chronic vocal fold scarring: from animal model to clinical application. Clin Exp Otorhinolaryngol 2017;10(4):349-56. https://doi.org/10.21053/ceo.2016.00941
  2. Sohn JH. The concept and management of vocal fold scarring. Korean J Otorhinolaryngol-Head Neck Surg 2005;48(4):426-34.
  3. Kim CS. Vocal fold regeneration: current review. Korean J Otorhinolaryngol-Head Neck Surg 2018;61(6):275-80. https://doi.org/10.3342/kjorl-hns.2018.00346
  4. Lee BJ. Trend of basic research for vocal fold scar. J Korean Soc Laryngol Phoniatr Logop 2012;23(1):28-32.
  5. Kanemaru S, Nakamura T, Omori K, Kojima H, Magrufov A, Hiratsuka Y, et al. Regeneration of the vocal fold using autologous mesenchymal stem cells. Ann Otol Rhinol Laryngol 2003;112(11):915-20. https://doi.org/10.1177/000348940311201101
  6. Kishimoto Y, Welham NV, Hirano S. Implantation of atelocollagen sheet for vocal fold scar. Curr Opin Otolaryngol Head Neck Surg 2010;18(6):507-11. https://doi.org/10.1097/MOO.0b013e32833febdc
  7. Tabata Y, Nagano A, Ikada Y. Biodegradation of hydrogel carrier incorporating fibroblast growth factor. Tissue Eng 1999;5(2):127-38. https://doi.org/10.1089/ten.1999.5.127