Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Physiological Activities of Policosanol Extracted from Sugarcane Wax

  • Jang, Yeon-su (College of Pharmacy, Duksung Women's University) ;
  • Kim, Dae-eun (College of Pharmacy, Duksung Women's University) ;
  • Han, Eunyoung (College of Pharmacy, Duksung Women's University) ;
  • Jung, Joohee (College of Pharmacy, Duksung Women's University)
  • Received : 2019.09.17
  • Accepted : 2019.11.24
  • Published : 2019.12.31
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Abstract

Policosanol extracted from sugarcane wax is a generic term used for total fatty alcohols obtained from esterification of fatty acids. It has been approved as a health functional food by the Ministry of Food and Drug Safety of Korea in 2006. Policosanol is well-known to aid in lowering blood cholesterol level. Recently, several studies have reported the physiological activities of policosanol, such as anti-inflammatory effects, antioxidant effects, and lowering of the incidence of ageing-related diseases, for example, hypertension, stroke, among others. This review describes the physiological activities of policosanol and its applications in the field of health functional foods.

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References

  1. Marinangeli, C. P.; Kassis, A. N.; Jain, D.; Ebine, N.; Cunnane, S. C.; Jones, P. J. Br. J. Nutr. 2007, 97, 381-388. https://doi.org/10.1017/S0007114507336763
  2. Committee for the Korean Guidelines for the Management of Dyslipidemia. Korean Circ. J. 2016, 46, 275-306. https://doi.org/10.4070/kcj.2016.46.3.275
  3. Marinangeli, C. P.; Jones, P. J.; Kassis, A. N.; Eskin, M. N. Crit. Rev. Food Sci. Nutr. 2010, 50, 259-267. https://doi.org/10.1080/10408391003626249
  4. Liao, F.; Chen, W. Hubei Agric. Sci. 2013, 52, 1125-1127.
  5. Singh, D. K.; Li, L.; Porter, T. D. J. Pharmacol. Exp. Ther. 2006, 318, 1020-1026. https://doi.org/10.1124/jpet.106.107144
  6. Banerjee, S.; Ghoshal, S.; Porter, T. D. Lipids 2011, 46, 311-321. https://doi.org/10.1007/s11745-011-3540-6
  7. Menendez, R.; Amor, A. M.; Gonzalez, R. M.; Fraga, V.; Mas, R. Biol. Res. 1996, 29, 253-257.
  8. Menendez, R.; Arruzazabala, L.; Mas, R.; Del Rio, A.; Amor. A. M.; Gonzalez, R. M.; Carbajal, D.; Fraga, V.; Molina, V.; Illnait, J. Br. J. Nutr. 1997, 77, 923-932. https://doi.org/10.1079/BJN19970090
  9. Arruzazabala, M. L.; Carbajal, D.; Mas, R.; Molina, V.; Valdes, S.; Laguna, A., Biol. Res., 1994, 27, 205-208.
  10. Arruzazabala, M. L.; Carbajal, D.; Mas, R.; Castano, G.; Sotolongo, R.; Mesa, R. Rev. CENIC Cien. Biol. 1991, 22, 60-61.
  11. Rodriguez-Echenique, C.; Mesa, R.; Mas, R.; Noa, M.; Menendez, R.; Gonzalez, R. M.; Amor, A. M.; Fraga, V.; Sotolongo, V.; Laguna, A. Food Chem. Toxicol. 1994, 32, 565-575. https://doi.org/10.1016/0278-6915(94)90115-5
  12. Hernandez, F.; Illnait, J.; Mas, R.; Castano, G.; Fernandez, L.; Gonzalez, M.; Cordovi, N.; Fernandez, J. C. Curr. Ther. Res. Clin. Exp. 1992, 51, 568-575.
  13. Castano, G.; Mas, R.; Fernandez, J.; Lopez, E.; Illnait, J.; Fernandez, L.; Mesa, M. Curr. Ther. Res. Clin. Exp. 2003, 64, 522-537. https://doi.org/10.1016/j.curtheres.2003.09.002
  14. Lopez, E.; Illnait, J.; Fernandez, J. C.; Fernandez, L.; Gamez, R.; Mesa, M.; Mendoza, S.; Mas, R.; Ruiz, D.; Jardines, Y. Rev. CRNIC Cien. Biol. 2010, 41, 31-37.
  15. Castano, G.; Mas, R.; Fernandez, L.; Illnait, J.; Hernandez, E.; Fernandez, J.; Gamez, R.; Gutierrez, C.; Alvarez, E. Curr. Ther. Res. 2002, 63, 286-303. https://doi.org/10.1016/S0011-393X(02)80033-9
  16. Illnait, J.; Lopez, E.; Fernandez, L.; Mas, R.; Gamez, R.; Mesa, M.; Mendoza, S.; Fernandez, J. C. Int. J. Pharm. Sci. Rev. Res. 2013, 22, 303-309.
  17. Lin, Y.; Rudrum, M.; van der Wielen, R. P.; Trautwein, E. A.; McNeill, G.; Sierksma, A.; Meijer, G. W. Metabolism 2004, 53, 1309-1314. https://doi.org/10.1016/j.metabol.2004.05.006
  18. Gouni-Berthold, I.; Berthold, H. K. Am. Heart J. 2002, 143, 356-365. https://doi.org/10.1067/mhj.2002.119997
  19. Tang, M.; Wu, S. Z.; Gong, X. Zhonghua Xin Xue Guan Bing Za Zhi 2013, 41, 488-492.
  20. Wang, H. Y.; Jiao, Q. P.; Chen, S. Y.; Sheng, J.; Jiang, H.; Lu, J.; Zheng, S. B.; Fang, N. Y. Am. J. Med. Sci. 2018, 356, 254-261. https://doi.org/10.1016/j.amjms.2018.06.014
  21. Careskey, H. E.; Davis, R. A.; Alborn, W. E.; Troutt, J. S.; Cao, G.; Konrad, R. J. J. Lipid Res. 2008, 49, 394-398. https://doi.org/10.1194/jlr.M700437-JLR200
  22. Welder, G.; Zineh, I.; Pacanowski, M. A.; Troutt, J. S.; Cao, G.; Konrad, R. J. J. Lipid Res. 2010, 51, 2714-2721. https://doi.org/10.1194/jlr.M008144
  23. Mousavi, S. A.; Berge, K. E.; Leren, T. P. J. Intern. Med. 2009, 266, 507-519. https://doi.org/10.1111/j.1365-2796.2009.02167.x
  24. Guo, Y. L.; Xu, R. X.; Zhu, C. G.; Wu, N. Q.; Cui, Z. P.; Li, J. J. Evid. Based Complement. Alternat. Med. 2014, 2014, 926087.
  25. Lee, H. Y. J. Korean Med. Assoc. 2018, 6, 485-492. https://doi.org/10.5124/jkma.2018.61.8.485
  26. Kim, S. J.; Yadav, D.; Park, H. J.; Kim, J. R.; Cho, K. H. Front. Physiol. 2018, 9, 412. https://doi.org/10.3389/fphys.2018.00412
  27. Cho, K. H.; Kim, S. J.; Yadav, D.; Kim, J. Y.; Kim, J. R. Oxid. Med. Cell. Longev. 2018, 2018, 4809525. https://doi.org/10.1155/2018/4809525
  28. Fraga, V.; Menendez, R.; Amor, A. M.; Gonzalez, R. M.; Jimenez, S.; Mas, R. Arch. Med. Res. 1997, 28, 355-360.
  29. Ng, C. H.; Leung, K. Y.; Huang, Y.; Chen, Z. Y. J. Agric. Food Chem. 2005, 53, 6289-6293. https://doi.org/10.1021/jf051269a
  30. Cicero, A. F.; Colletti, A. Phytomedicine 2016, 23, 1113-1118. https://doi.org/10.1016/j.phymed.2015.10.011
  31. Castano, G.; Menendez, R.; Mas, R.; Amor, A.; Fernandez, J. L.; Gonzalez, R. L.; Lezcay, M.; Alvarez, E. Int. J. Clin. Pharmacol. Res. 2002, 22, 89-99.
  32. Harrabi, S.; Ferchichi, A.; Bacheli, A.; Fellah, H. Lipids Health Dis. 2018, 17, 82. https://doi.org/10.1186/s12944-018-0682-z
  33. Castano, G.; Fernandez, L.; Mas, R.; Illnait, J.; Mesa, M.; Fernandez, J. C. Clin. Drug Investig. 2003, 23, 639-650. https://doi.org/10.2165/00044011-200323100-00003
  34. Elseweidy, M. M.; Zein, N.; Aldhamy, S. E.; Elsawy, M. M.; Saeid, S. A. Exp. Biol. Med. 2016, 241, 1943-1949. https://doi.org/10.1177/1535370216659943
  35. Kaup, R. M.; Khayyal, M. T.; Verspohl, E. J. Phytother. Res. 2013, 27, 264-271. https://doi.org/10.1002/ptr.4705
  36. Elseweidy, M. M.; Mohamed, H. E.; Elrashidy, R. A.; Atteia, H. H.; Elnagar, G. M. J. Cardiovasc. Pharmacol. Ther. 2018, 23, 551-560. https://doi.org/10.1177/1074248418775377
  37. Noa, M.; Mas, R.; de la Rosa, M. C.; Magraner, J. J. Pharm. Pharmacol. 1995, 47, 289-291. https://doi.org/10.1111/j.2042-7158.1995.tb05797.x
  38. Carbajal, D.; Arruzazabala, M. L.; Valdes, S.; Mas, R. Prostaglandins, Leukot. Essent. Fatty Acids 1998, 58, 61-64. https://doi.org/10.1016/S0952-3278(98)90130-2
  39. Arruzazabala, M. L.; Mas, R.; Molina, V.; Carbajal, D.; Mendoza, S.; Fernandez, L.; Valdes, S. Int. J. Tissue React. 1998, 20, 119-124.
  40. Wong, W. T.; Ismail, M.; Tohit, E. R.; Abdullah, R.; Zhang, Y. D. Evid. Based Complement. Alternat. Med. 2016, 2016, 7343942.
  41. Wong, W. T.; Ismail, M.; Imam, M. U.; Zhang, Y. D. BMC Complement. Altern. Med. 2016, 16, 252. https://doi.org/10.1186/s12906-016-1223-9
  42. Illnait, J.; Castano, G.; Alvarez, E.; Fernandez, L.; Mas, R.; Mendoza, S.; Gamez, R. Angiology 2008, 59, 269-277. https://doi.org/10.1177/0003319707306963
  43. Molina, V.; Ravelo, Y.; Noa, M.; Mas, R.; Perez, Y.; Oyarzabal, A.; Mendoza, N.; Valle, M.; Jimenez, S.; Sanchez, J. Indian J. Pharm. Sci. 2013, 75, 635-641.
  44. Ortega, L. L.; Sanchez, J.; Mas, R.; Fernandez, L.; Mendoza, S.; Gamez, R.; Fernandez, J. C.; Illnait, J.; Alvarez, E. J. Med. Food 2006, 9, 378-385. https://doi.org/10.1089/jmf.2006.9.378
  45. Sanchez, J.; Fernandez, L. Illnait, J.; de Lourdes Arruzazabala, M.; Molina, V.; Mas, R.; Mendoza, S. Carbajal, D. Mesa, M.; Fernandez, J. IOSR J. Pharm. 2012, 2, 14-24.
  46. Sanchez, J.; Illnait, J.; Mas, R.; Mendoza, S.; Fernandez, L.; Mesa, M.; Vega, H.; Fernandez, J.; Reyes, P.; Ruiz, D. Rev. Neurol. 2017, 64, 153-161. https://doi.org/10.33588/rn.6404.2016180
  47. Sanchez, J.; Illnait, J.; Mas, R.; Mendoza, S.; Vega, H.; Fernandez, L.; Mesa, M.; Fernandez, J.; Reyes, P.; Ruiz, D. Int. J. Pharm. Sci. Rev. Res. 2016, 37, 7-14.
  48. Sanchez, J.; Illnait, J.; Mas, R.; Perez, Y.; Mendoza, S.; Cabrera, L.; Fernandez, L.; Mesa, M.; Fernandez, J.; Oyarzabal, A.; Molona, V.; Reyes, P. IOSR J. Pham. 2013, 3, 31-40.
  49. Sanchez-Lopez, J.; Fernandez-Travieso, J. C.; Illnait-Ferrer, J.; Fernandez-Dorta, L.; Mendoza-Castano, S.; Mas-Ferreiro, R.; Mesa-Angarica, M.; Reyes-Suarez, P. Rev. de Neuro. 2018, 67, 331-338. https://doi.org/10.33588/rn.6709.2018063
  50. Lee, E. Y.; Yoo, J. A.; Lim, S. M.; Cho, K. H. Rejuvenation Res. 2016, 19, 149-158. https://doi.org/10.1089/rej.2015.1745
  51. Lim, S. M.; Yoo, J. A.; Lee, E. Y.; Cho, K. H. Rejuvenation Res. 2016, 19, 59-70. https://doi.org/10.1089/rej.2015.1712
  52. Lee, J. H.; Jia, Y.; Thach, T. T.; Han, Y.; Kim, B.; Wu, C.; Kim, Y.; Seo, W. D.; Lee, S. J. Nutr. Res. 2017, 43, 89-99. https://doi.org/10.1016/j.nutres.2017.05.013
  53. Lim, D.; Ha, M.; Song, I. J. Korean Med. Sci. 2014, 29, 1597-1603. https://doi.org/10.3346/jkms.2014.29.12.1597