BMB Reports
- Volume 51 Issue 11
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- Pages.545-546
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- 2018
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- 1976-670X(eISSN)
DOI QR Code
Immune inflammatory modulation as a potential therapeutic strategy of stem cell therapy for ALS and neurodegenerative diseases
- Kim, Seung Hyun (Department of Neurology, College of Medicine, Hanyang University) ;
- Oh, Ki-Wook (Department of Neurology, College of Medicine, Hanyang University) ;
- Jin, Hee Kyung (Stem Cell Neuroplasticity Research Group) ;
- Bae, Jae-Sung (Stem Cell Neuroplasticity Research Group)
- Received : 2018.10.23
- Published : 2018.11.30
Abstract
With emerging evidence on the importance of non-cell autonomous toxicity in neurodegenerative diseases, therapeutic strategies targeting modulation of key immune cells. including microglia and Treg cells, have been designed for treatment of ALS and other neurodegenerative diseases. Strategy switching the patient's environment from a pro-inflammatory toxic to an anti-inflammatory, and neuroprotective condition, could be potential therapy for neurodegenerative diseases. Mesenchymal stem cells (MSCs) regulate innate and adaptive immune cells, through release of soluble factors such as