Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
권호 표지
DOI QR코드

DOI QR Code

Quality Management of Radionuclide Activity Meter using Ge-68/Ga-68 Rod Sources

Ge-68/Ga-68 Rod Sources을 이용한 방사능측정기의 정도관리

  • Received : 2018.09.10
  • Accepted : 2018.10.31
  • Published : 2018.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

This article compared accuracy of 5 types of radionuclide activity meters that are being used in medical institutions and proposed the correction factor for each radionuclide activity meters type, using Ge-68/Ga-68 radiation sources for scanner setting, regular scanner correction, attenuation correction, and normalization. The calibration constant between baseline values and measured values by CRC-15R, CRC-15 PET, CRC-712M, CRC-15 Beta, and CRC-25PET was 0.99999(P<0.0001), which showed very high linearity. In the accuracy test, CRC-15R, CRC-15 PET, CRC-712M, CRC-15 Beta, and CRC-25PET model showed -3.232%, -1.342%, -2.815%, -2.913%, and -3.089% respectively.

PET와 PET/CT의 검사 영상품질관리를 위해서는 F-18 방사능측정기의 정도관리가 필요하다. Ge-68/Ga-68 Rod Sources을 선원을 이용하여 의료기관에서 사용하고 있는 5종류의 방사능측정기의 방사능 측정의 정확도와 정밀도를 확인하였다. CRC-15R, CRC-15 PET, CRC-712M, CRC-15 베타 및 CRC-25PET에 대한 측정값과 기준값 사이의 방사능 양에 따른 상관관계는 0.99999 (P <0.0001)로 매우 높은 선형성을 보였다. 정확도 테스트에서 CRC-15R, CRC-15 PET, CRC-712M, CRC-15 베타 및 CRC-25PET 모델은 각각 -3.232 %, -1.342 %, -2.815 %, -2.913 % 및 -3.089 %를 이었다. 국내와 국제기준인 정확도 ${\pm}10%$, 정밀도 ${\pm}5%$ 이내로 기준을 만족하였고 반감기가 짧은 F-18에 비하여 경제성 있고 비교적 긴 기간 동안 안정적으로 정도관리가 가능하다는 것을 확인하였다.

Keywords

References

  1. P.W. Grigsby, B.A. Siegel, F. Dehdashti, D.G.Mutch, "Posttherapy surveillance monitoring of cervical cancer by FDG-PET," International Journal of Radiation Oncology.Biology.Physics, Vol. 55, No. 4, pp. 907-913, 2003. https://doi.org/10.1016/S0360-3016(02)04287-6
  2. L.J. Havrilesky, S.L. Kulasingam, D.B. Matchar, E.R. Myers, "FDG-PET for management of cervical and ovarian cancer," Gynecologic oncology, Vol. 97, No. 1, pp. 183-191, 2005. https://doi.org/10.1016/j.ygyno.2004.12.007
  3. R.S. Malyapa, S. Mutic, D.A. Low, I. Zoberi, W.R. Bosch, R. Laforest, P.W. Grigsby, "Physiologic FDG-PET three-dimensional brachytherapy treatment planning for cervical cancer," International Journal of Radiation Oncology.Biology.Physics, Vol. 54, No. 4, pp. 1140-1146, 2002. https://doi.org/10.1016/S0360-3016(02)03043-2
  4. H.H. Park, D.S. Park, D.C. Kweon, S.B. Lee, K.B. Oh, J.D. Lee, G.H. Jin, "Inter-comparison of 18F-FDG PET/CT standardized uptake values in Korea," Applied Radiation and Isotopes, Vol. 69, No. 1, pp. 241-246, 2011. https://doi.org/10.1016/j.apradiso.2010.09.011
  5. M.J. Reinhardt, C. Ehritt-Braun, D. Vogelgesang, C. Ihling, S. Hogerle, M. Mix, T.M. Krause, T. M. "Metastatic lymph nodes in patients with cervical cancer: detection with MR imaging and FDG PET," Radiology, Vol. 218, No. 3, pp. 776-782, 2001. https://doi.org/10.1148/radiology.218.3.r01mr19776
  6. S.Y. Ryu, M.H. Kim, S.C. Choi, C.W. Choi, K.H. Lee, "Detection of early recurrence with 18F-FDG PET in patients with cervical cancer," Journal of Nuclear Medicine, Vol. 44, No. 3, pp. 347, 2003.
  7. Y. Sugawara, A. Eisbruch, S. Kosuda, B.E. Recker, P.V. Kison, R.L. Wahl, "Evaluation of FDG PET in patients with cervical cancer," Journal of Nuclear Medicine, Vol. 40, No. 7, pp. 1125, 1999.
  8. G.H. Jin, D.C. Kweon, K.B. Oh, H.H. Park, J.Y. Kim, M.S. Park, D.S. Park, "Comparison of F-18 FDG radioacitivity to determine accurate dose calibrator activity measurements," Korean Journal of Medical Physics, Vol. 20, No. 3, pp. 159-166, 2009.
  9. K.B. Lee, "Development of calibration technique of dose calibrator for FDG radiopharmaceutical," National Institute of Food and Drug Safety Evaluation, Korea, 2009.
  10. N. O'Brien, M. Zimmer, N. McDonald, S. Spies, S. "Accuracy of F-18 calibration settings in commercial dose calibrators using a new traceable Ge-68 standard," Journal of Nuclear Medicine, Vol. 51, Vol. 2, pp. 2112, 2010.
  11. B. McKay, M. Zimmer, P. Flaten, S. Spies, "Accuracy of F-18 calibration settings in commercial dose calibrators using multiple Ge-68 traceable standards," Journal of Nuclear Medicine, Vol. 57, No. 2, pp. 2731, 2016.
  12. B.E. Zimmerman, J.T. Cessna, R. Fitzgerald, R. "Standardization of 68Ge/68Ga using three liquid scintillation counting based methods," Journal of research of the National Institute of Standards and Technology, Vol. 113, No. 5, pp. 265, 2008. https://doi.org/10.6028/jres.113.020
  13. B. Zimmerman, P. Kinahan, W. Galbraith, K. Allberg, O. Mawlawi, "Multicenter comparison of dose calibrator accuracy for PET imaging using a standardized source". Journal of Nuclear Medicine, Vol. 50, No. 2, pp. 472-472, 2009.
  14. B.E. Zimmerman, J.T. Cessna, J. T. "Development of a traceable calibration methodology for solid 68Ge/68Ga sources used as a calibration surrogate for 18F in radionuclide activity calibrators," Journal of Nuclear Medicine, Vol. 51, No. 3, pp. 448, 2010. https://doi.org/10.2967/jnumed.109.070300
  15. G.F. Knoll, G. F. "Radiation detection and measurement," John Wiley & Sons, 2010.
  16. Table of radioactive isotopes, http://nucleardata.nuclear.lu.se/toi/nucSearch.asp (accessed 10 February 2018)
  17. C. O'Farrell, M. Zimmer, N. McDonald, S. Spies, S. "Accuracy of the F-18 calibration setting with a Capintec dose calibrator," Journal of Nuclear Medicine, Vol. 49, No. 1, pp. 435, 2008.
  18. L. Mo, M.I. Reinhard, J.B. Davies, D.Alexiev, C. Baldock, "Calibration of the Capintec CRC-712M dose calibrator for 18F," Applied radiation and isotopes, Vol. 64, No. 4, pp. 485-489, 2006. https://doi.org/10.1016/j.apradiso.2005.09.006
  19. R.N. Dansereau, B.M. Methe, "Dose variance associated with calibration and administration of radiopharmaceuticals," American journal of health-system pharmacy, Vol. 58, No. 7, pp. 580-584, 2001. https://doi.org/10.1093/ajhp/58.7.580
  20. H.K. Son, H.J. Kim, H.J. Jung, H.K. Jeong, J.D. Lee, H.S. Yoo, "A study of quality control of nuclear medicine counting system and gamma camera," Korean Journal of Medical Physics. Vol. 12, No. 2, pp. 103-112, 2001.