Journal of the Korean Ceramic Society (한국세라믹학회지)

The Korean Ceramic Society (한국세라믹학회)
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Calcium Phosphate Bone Cement Based on Wet Prepared Dicalcium Phosphate

  • Chang, Myung Chul (Department of Materials Science and Engineering, Kunsan National University)
  • Received : 2018.06.09
  • Accepted : 2018.07.29
  • Published : 2018.09.30
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Abstract

Calcium phosphates (CaP) were prepared by a wet chemical method. Micro-crystalline dicalcium phosphate (DCPD) was precipitated at $37^{\circ}C$ and pH 5.0 using $Ca(OH)_2$ and $H_3PO_4$. The precipitated DCPD solution was kept at $37^{\circ}C$ for 96 h. Artificial bone cement was composed of DCPD, $Ca(H_2PO_4)_2{\cdot}H_2O$ (MCPM), and $CaSO_4{\cdot}1/2H_2O$, $H_2O$ and aqueous poly-phosphoric acid solution. The wet prepared CaP powder was used as a matrix for the bone cement recipe. With the addition of aqueous poly-phosphoric acid, the cement hardening reaction was started and the CaP bone cement blocks were fabricated for the mechanical strength measurement. For the tested blocks, the mechanical strength was measured using a universal testing machine, and the microstructure phase analysis was done by field emission scanning electron microscopy and X-ray diffraction. The cement hardening reaction occurred through the decomposition and recrystallization of MCPM and $CaSO_4{\cdot}1/2H_2O$ added on the surface of the wet prepared CaP, and this resulted in grain growth in the bone cement block.

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References

  1. W. E. Brown and L. C. Chow, "A New Calcium Phosphate Water-Setting Cement," pp. 351-79 in Cement Research Progress, Ed. by P. W. Brown, The American Ceramic Society, Ohio, 1986.
  2. L. C. Chow, "Development of Self-Setting Calcium Phosphate Cements," J. Ceram. Soc. Jpn., 99 [1154] 954-64 (1991). https://doi.org/10.2109/jcersj.99.954
  3. M. C. Chang, "Precipitation of Calcium Phosphate at pH 5.0 for the ${\beta}$ Tri-calcium Phosphate Cement," J. Korean Ceram. Soc., 50 [4] 275-79 (2013). https://doi.org/10.4191/kcers.2013.50.4.275
  4. M. C. Chang, "The Influence of Nano-TCP Powders in the ${\beta}$-TCP - Based Artificial Bone Synthesis," Biomater. Res., 17 [3] 121-25 (2013).
  5. M. C. Chang, "Use of Wet Chemical Method to Prepare ${\beta}$ Tri-Calcium Phosphates Having Macro- and Nano-Crystallites for Artificial Bone," J. Korean Ceram. Soc., 53 [6] 670-75 (2016). https://doi.org/10.4191/kcers.2016.53.6.670
  6. M. C. Chang and R. DeLong, "Calcium Phosphate Formation in Gelatin Matrix Using Free Ion Precursors of $Ca^{2+}$ and Phosphate Ions," Dent. Mater., 25 [2] 261-68 (2009). https://doi.org/10.1016/j.dental.2008.07.005
  7. R. A. Young, "Biological Apatite vs. Hydroxyapatite at the Atomic Level," Clin. Orthop. Relat. Res., 113 249-60 (1975). https://doi.org/10.1097/00003086-197511000-00036
  8. W. R. Walsha, F. Vizesia, D. Michaela, J. Aulda, A. Langdown, R. Oliver, Y. Yu, H. Irie, and W. Bruce, "${\beta}$-TCP Bone Graft Substitutes in a Bilateral Rabbit Tibial Defect Model," Biomaterials, 29 [3] 266-71 (2008). https://doi.org/10.1016/j.biomaterials.2007.09.035
  9. S. Metsger, T. D. Driskell, and J. R. Paulsrud, "Tricalcium Phosphate Ceramic - A Restorable Bone Implant: Review and Current Status," J. Am. Dent. Assoc., 105 [6] 1035-38 (1982). https://doi.org/10.14219/jada.archive.1982.0408
  10. H.-B. Pan and B. W. Darvell, "Solubility of TTCP and ${\beta}$-TCP by Solid Titration," Arch. Oral Biol., 54 [7] 671-77 (2009). https://doi.org/10.1016/j.archoralbio.2008.01.001
  11. I. R. Gibson, I. Rehman, S. M. Best, and W. Bonfield, "Characterization of the Transformation from Calcium Deficient Apatite to ${\beta}$-tricalcium Phosphate," J. Mater. Sci.: Mater. Med., 11 [12] 799-804 (2000). https://doi.org/10.1023/A:1008905613182
  12. J. S. Bow, S. C. Liou, and S. Y. Chen, "Structural Characterization of Room-Temperature Synthesized Nano-Sized ${\beta}$-tricalcium Phosphate," Biomaterials, 25 [16] 3155-61 (2004). https://doi.org/10.1016/j.biomaterials.2003.10.046
  13. B. Mirhadi, B. Mehdikhani, and N. Askari, "Synthesis of Nano-sized ${\beta}$-tricalcium Phosphate via Wet Precipitation," Process. Appl. Ceram., 5 [4] 193-98 (2011). https://doi.org/10.2298/PAC1104193M
  14. B. M. Fathi, A. El Yacoubi, A. Massit, and B. C. E. Idrissi, "Wet Chemical Method for Preparing High Purity ${\beta}$ and ${\alpha}$-Tricalcium Phosphate Crystalline Powders," Int. J. Sci. Eng. Res., 6 [6] 139-42 (2015).
  15. L. M-Alonso, M. Motisuke, J. R. Correa, R. G. Carrode guas, and L. A. dos Santos, "In situ Synchrotron X-ray Powder Diffraction Study of the Early Hydration of ${\alpha}$-tricalcium Phosphate/Tricalcium Silicate Composite Bone Cement," Mater. Res., 18 [1] 164-69 (2015). https://doi.org/10.1590/1516-1439.302114
  16. L. C. Chow and E. D. Eanes, "Calcium Phosphate Cements," pp. 148-63 in Monographs Oral Science, Vol. 18, Karger, Basel, 2001.
  17. Sergey V. Dorozhkin, "Self-Setting Calcium Orthophosphate Formulations," J. Funct. Biomater., 4 [1] 209-311 (2013). https://doi.org/10.3390/jfb4040209
  18. M. Schamel, J. E. Barralet, J. Groll, and U. Gbureck, "In vitro Ion Adsorption and Cytocompatibility of Dicalcium Phosphate Ceramics," Biomater. Res., 21 [10] 1-8 (2017). https://doi.org/10.1186/s40824-016-0087-x
  19. K. Tsuru, A. Yoshimoto, M. Kanazawa, Y. Sugiura, Y. Nakashima, and K. Ishikawa, "Fabrication of Carbonate Apatite Block through a Dissolution-Precipitation Reaction Using Calcium Hydrogen Phosphate Dihydrate Block as a Precursor," Materials, 10 [4] 374-83 (2017). https://doi.org/10.3390/ma10040374
  20. M. Komath, H. K. Varma, and R. Sivakumar, "On the Development of an Apatitic Calcium Phosphate Bone Cement," Bull. Mater. Sci., 23 [2] 135-40 (2000). https://doi.org/10.1007/BF02706555
  21. T. Toshima, R. Hamai, M. Tafu, Y. Takemura, S. Fujita, T. Chohji, S. Tanda, S. Li, and G. W. Qin, "Morphology control of Brushite Prepared by Aqueous Solution Synthesis," J. Asian Ceram. Soc., 2 [1] 52-6 (2014). https://doi.org/10.1016/j.jascer.2014.01.004
  22. F. Tamimi, Z. Sheikh, and J. Barralet, "Dicalcium Phosphate Cements: Brushite and Monetite," Acta Biomater., 8 [2] 474-87 (2012). https://doi.org/10.1016/j.actbio.2011.08.005
  23. A. Kishida, T. Taguchi, and M. Akashi, "Novel Surface Treatment Conferring Biocompatibility: Apatite Formation on Materials for Artificial Organs Induced by Alternate Soaking Process," Jpn. J. Artif. Organs, 29 [2] 452-56 (2000).
  24. M. Nilsson, E. Fernandez, S. Sarda, L. Lidgren, and J. A. Planell, "Microstructure Analysis of Novel Resorbable Calcium Phosphate/Sulphate Bone Cements," Key Eng. Mater., 218-220 365-68 (2002).
  25. M. Nilsson, E. Fernandez, S. Sarda, L. Lidgren, and J. A. Planell, "Characterization of a Novel Calcium Phosphate/ Sulphate Bone Cement," J. Biomed. Mater. Res., 61 [4] 600-7 (2002). https://doi.org/10.1002/jbm.10268