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Comparison of conservative therapy and steroid therapy for Bell's palsy in children

  • Yoo, Hye Won (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Yoon, Lira (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Kim, Hye Young (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Kwak, Min Jung (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Park, Kyung Hee (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Bae, Mi Hye (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Lee, Yunjin (Department of Pediatrics, Pusan National University Yangsan Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Nam, Sang Ook (Department of Pediatrics, Pusan National University Yangsan Hospital, Pusan National University School of Medicine and Biochemical Research Institute) ;
  • Kim, Young Mi (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine and Biochemical Research Institute)
  • Received : 2018.03.02
  • Accepted : 2018.05.02
  • Published : 2018.10.15

Abstract

Purpose: Bell's palsy is characterized by sudden onset of unilateral facial weakness. The use of corticosteroids for childhood Bell's palsy is controversial. This study aimed to identify clinical characteristics, etiology, and laboratory findings in childhood Bell's palsy, and to evaluate the efficacy of corticosteroid treatment. Methods: We conducted a retrospective analysis of children under 19 years of age treated for Bell's palsy between January 2009 and June 2017, and followed up for over 1 month. Clinical characteristics, neuroimaging data, laboratory findings, treatments, and outcomes were reviewed. Patients with Bell's palsy were divided into groups with (group 1) and without (group 2) corticosteroid treatment. Differences in onset age, sex, laterality, infection and vaccination history, degree of facial nerve palsy, and prognosis after treatment between the groups were analyzed. Results: One hundred patients were included. Mean age at presentation was $7.4{\pm}5.62years$. A total of 73 patients (73%) received corticosteroids with or without intravenous antiviral agents, and 27 (27%) received only supportive treatment. There was no significant difference in the severity, laboratory findings, or neuroimaging findings between the groups. Significant improvement was observed in 68 (93.2%) and 26 patients (96.3%) in groups 1 and 2, respectively; this rate was not significantly different between the groups (P=0.48). Conclusion: Childhood Bell's palsy showed good prognosis with or without corticosteroid treatment; there was no difference in prognosis between treated and untreated groups. Steroid therapy in childhood Bell's palsy may not significantly improve outcomes.

Keywords

References

  1. Jenke AC, Stoek LM, Zilbauer M, Wirth S, Borusiak P. Facial palsy: etiology, outcome and management in children. Eur J Paediatr Neurol 2011;15:209-13. https://doi.org/10.1016/j.ejpn.2010.11.004
  2. Peitersen E. Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl 2002:4-30.
  3. Kanerva M, Nissinen J, Moilanen K, Maki M, Lahdenne P, Pitkaranta A. Microbiologic findings in acute facial palsy in children. Otol Neurotol 2013;34:e82-7. https://doi.org/10.1097/MAO.0b013e318289844c
  4. Cope D, Bova R. Steroids in otolaryngology. Laryngoscope 2008;118:1556-60. https://doi.org/10.1097/MLG.0b013e31817c0b4d
  5. Sullivan FM, Swan IR, Donnan PT, Morrison JM, Smith BH, McKinstry B, et al. Early treatment with prednisolone or acyclovir in Bell's palsy. N Engl J Med 2007;357:1598-607. https://doi.org/10.1056/NEJMoa072006
  6. Salinas RA, Alvarez G, Daly F, Ferreira J. Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev 2010:CD001942.
  7. Grundfast KM, Guarisco JL, Thomsen JR, Koch B. Diverse etiologies of facial paralysis in children. Int J Pediatr Otorhinolaryngol 1990;19:223-39. https://doi.org/10.1016/0165-5876(90)90002-9
  8. Williamson IG, Whelan TR. The clinical problem of Bell's palsy: is treatment with steroids effective? Br J Gen Pract 1996;46:743-7.
  9. Rowhani-Rahbar A, Klein NP, Lewis N, Fireman B, Ray P, Rasgon B, et al. Immunization and Bell's palsy in children: a case-centered analysis. Am J Epidemiol 2012;175:878-85. https://doi.org/10.1093/aje/kws011
  10. Chen WX, Wong V. Prognosis of Bell's palsy in children--analysis of 29 cases. Brain Dev 2005;27:504-8. https://doi.org/10.1016/j.braindev.2005.01.002
  11. Arican P, Dundar NO, Gencpinar P, Cavusoglu D. Efficacy of lowdose corticosteroid therapy versus high-dose corticosteroid therapy in Bell's palsy in children. J Child Neurol 2017;32:72-5. https://doi.org/10.1177/0883073816668774
  12. Holland NJ, Weiner GM. Recent developments in Bell's palsy. BMJ 2004;329:553-7. https://doi.org/10.1136/bmj.329.7465.553
  13. Adour KK, Ruboyianes JM, Von Doersten PG, Byl FM, Trent CS, Quesenberry CP Jr, et al. Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. Ann Otol Rhinol Laryngol 1996;105:371-8. https://doi.org/10.1177/000348949610500508
  14. Hyden D, Roberg M, Forsberg P, Fridell E, Fryden A, Linde A, et al. Acute "idiopathic" peripheral facial palsy: clinical, serological, and cerebrospinal fluid findings and effects of corticosteroids. Am J Otolaryngol 1993;14:179-86. https://doi.org/10.1016/0196-0709(93)90027-5
  15. De Diego JI, Prim MP, De Sarria MJ, Madero R, Gavilan J. Idiopathic facial paralysis: a randomized, prospective, and controlled study using single-dose prednisone versus acyclovir three times daily. Laryngoscope 1998;108:573-5. https://doi.org/10.1097/00005537-199804000-00020
  16. Youshani AS, Mehta B, Davies K, Beer H, De S. Management of Bell's palsy in children: an audit of current practice, review of the literature and a proposed management algorithm. Emerg Med J 2015;32:274-80. https://doi.org/10.1136/emermed-2013-202385
  17. Shih WH, Tseng FY, Yeh TH, Hsu CJ, Chen YS. Outcomes of facial palsy in children. Acta Otolaryngol 2009;129:915-20. https://doi.org/10.1080/00016480802468179
  18. Unuvar E, Oguz F, Sidal M, Kilic A. Corticosteroid treatment of childhood Bell's palsy. Pediatr Neurol 1999;21:814-6. https://doi.org/10.1016/S0887-8994(99)00099-5

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