Clinical Nutrition Research

The Korean Society of Clinical Nutrition (한국임상영양학회)
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Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects

  • Lee, Hee Jae (Department of Food and Nutrition, Seoul Women's University) ;
  • Seo, Hye In (Department of Food and Nutrition, Seoul Women's University) ;
  • Cha, Hee Yun (Department of Food and Nutrition, Seoul Women's University) ;
  • Yang, Yun Jung (Department of Food and Nutrition, Seoul Women's University) ;
  • Kwon, Soo Hyun (Department of Food and Nutrition, Seoul Women's University) ;
  • Yang, Soo Jin (Department of Food and Nutrition, Seoul Women's University)
  • Received : 2018.09.24
  • Accepted : 2018.10.14
  • Published : 2018.10.31
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Abstract

Blood glucose homeostasis is well maintained by coordinated control of various hormones including insulin and glucagon as well as cytokines under normal conditions. However, chronic exposure to diabetic environment with high fat/high sugar diets and physical/mental stress can cause hyperglycemia, one of main characteristics of insulin resistance, metabolic syndrome, and diabetes. Hyperglycemia impairs organogenesis and induces organ abnormalities such as cardiac defect in utero. It is a risk factor for the development of metabolic diseases in adults. Resulting glucotoxicity affects peripheral tissues and vessels, causing pathological complications including diabetic neuropathy, nephropathy, vessel damage, and cardiovascular diseases. Moreover, chronic exposure to hyperglycemia can deteriorate cognitive function and other aspects of mental health. Recent reports have demonstrated that hyperglycemia is closely related to the development of cognitive impairment and dementia, suggesting that there may be a cause-effect relationship between hyperglycemia and dementia. With increasing interests in aging-related diseases and mental health, diabetes-related cognitive impairment is attracting great attention. It has been speculated that glucotoxicity can result in structural damage and functional impairment of brain cells and nerves, hemorrhage of cerebral blood vessel, and increased accumulation of amyloid beta. These are potential mechanisms underlying diabetes-related dementia. Nutrients and natural food components have been investigated as preventive and/or intervention strategy. Among candidate components, resveratrol, curcumin, and their analogues might be beneficial for the prevention of diabetes-related cognitive impairment. The purposes of this review are to discuss recent experimental evidence regarding diabetes and cognitive impairment and to suggest potential nutritional intervention strategies for the prevention and/or treatment of diabetes-related dementia.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF), Seoul Women's University

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