Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Association of polymorphisms in Pit-1 gene with growth and feed efficiency in meat-type chickens

  • Jin, Sihua (College of Animal Science and Technology, Anhui Agricultural University) ;
  • He, Tingting (College of Animal Science and Technology, Anhui Agricultural University) ;
  • Yang, Lei (College of Animal Science and Technology, Anhui Agricultural University) ;
  • Tong, Yucui (College of Animal Science and Technology, Anhui Agricultural University) ;
  • Chen, Xingyong (College of Animal Science and Technology, Anhui Agricultural University) ;
  • Geng, Zhaoyu (College of Animal Science and Technology, Anhui Agricultural University)
  • Received : 2018.02.27
  • Accepted : 2018.06.27
  • Published : 2018.11.01
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Abstract

Objective: The pituitary specific transcription factor-1 (Pit-1) gene is responsible for pituitary development and growth hormone expression and is regarded as a pivotal candidate gene for growth and production in chickens. Therefore, the aim of this study was to investigate the association of Pit-1 polymorphisms with growth and feed efficiency traits in yellow meat-type chickens. Methods: In the present study, five single nucleotide polymorphisms (SNPs) of Pit-1 were selected and genotyped by high-throughput matrix-assisted laser desorption-ionization time-of-flight mass spectrometry in 724 meat-type chickens. Results: Association analysis showed that rs13687126 of Pit-1 was strongly associated with body weight gain (BWG) and feed intake (FI) (p<0.05), and that rs13687128 was significantly correlated with body weight at 70 days of age (BW70), BWG and feed conversion ratio (FCR) (p<0.05). SNP rs13905622 was strongly related to BW70 and FCR (p<0.05). Furthermore, birds with the GG genotype of rs13687126 had larger BWG and FI than those with the AG genotype (p<0.05). Individuals with the TT genotype of rs13687128 were significantly higher BW70 and BWG than those of the CT and CC genotype, while FCR was just the opposite (p<0.05). For rs13905622, the AA chickens showed strongly larger BW70 and lower FCR compared with the AT and TT chickens (p<0.05). Additionally, an ACA haplotype based on rs13687126, rs13687128, and rs13905622 had significant effects on BW70 and FCR (p<0.05). Conclusion: Our studies thus provide crucial evidence for the relationship between polymorphisms of Pit-1 and growth and feed efficiency traits which may be useful for meat-type chicken breeding programs.

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References

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