Tissue Engineering and Regenerative Medicine

  • 제15권6호
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  • Pages.699-709
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  • 2018
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  • 1738-2696(pISSN)
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  • 2212-5469(eISSN)
한국조직공학·재생의학회 (Korean Tissue Engineering and Regenerative Medicine Society)
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DOI QR코드

DOI QR Code

Current Status of Stem Cell Treatment for Type I Diabetes Mellitus

  • Kakkar, Anupama (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.) ;
  • Sorout, Ashima (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.) ;
  • Tiwari, Mahak (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.) ;
  • Shrivastava, Pallavi (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.) ;
  • Meena, Poonam (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.) ;
  • Kumar Saraswat, Sumit (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.) ;
  • Srivastava, Supriya (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.) ;
  • Datt, Rajan (Datt Mediproducts Pvt Ltd.) ;
  • Pandey, Siddharth (Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd.)
  • 투고 : 2018.06.01
  • 심사 : 2018.07.04
  • 발행 : 2018.12.01
⟨ 이전 논문 다음 논문 ⟩

초록

BACKGROUND: Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans. METHODS: Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as in vitro MSCs differentiated into ${\beta}$ islet cells. RESULTS: These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms. CONCLUSION: Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.

키워드

참고문헌

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