Neonatal Medicine

  • 제25권4호
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  • Pages.191-195
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  • 2018
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  • 2287-9412(pISSN)
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  • 2287-9803(eISSN)
대한신생아학회 (The Korean Society of Neonatology)
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Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant

  • Kim, Hye-Eun (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Kim, Do Hee (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Chung, Sung-Hoon (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Bae, Chong-Woo (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Choi, Yong-Sung (Department of Pediatrics, Kyung Hee University School of Medicine)
  • 투고 : 2018.07.24
  • 심사 : 2018.09.14
  • 발행 : 2018.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the gene encoding CD18, which is a constituent of leukocyte integrins. Clinical features usually begin with a delay in the separation of the umbilical cord in the neonatal period, and are characterized by marked leukocytosis with infection, delayed wound healing, and repeated bacterial and fungal infections. We experienced a case of leukocyte adhesion deficiency diagnosed in the neonatal period, in which a late preterm infant admitted to neonatal intensive care unit presented with a septic hip. Flow cytometry analysis of whole blood showed a decrease in the expression of CD11b/CD18. This is the first case of leukocyte adhesion deficiency with neonatal septic hip diagnosed in Korea.

키워드

참고문헌

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