DOI QR코드

DOI QR Code

경두개 자기자극과 확산텐서 신경섬유로 검사를 통한 대뇌 병변의 국소화: 증례보고

Localization of Bilateral Hemisphere Lesion Using Combined Transcranial Magnetic Stimulation and Diffusion Tensor Imaging: Report of Two Cases

  • 이형남 (전북대학교병원 재활의학과) ;
  • 오영빈 (전북대학교병원 재활의학과) ;
  • 김기욱 (전북대학교병원 재활의학과) ;
  • 원유희 (전북대학교병원 재활의학과) ;
  • 고명환 (전북대학교병원 재활의학과) ;
  • 서정환 (전북대학교병원 재활의학과) ;
  • 박성희 (전북대학교병원 재활의학과)
  • Lee, Hyung Nam (Department of Physical Medicine & Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Oh, Young-Bin (Department of Physical Medicine & Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Kim, Gi-Wook (Department of Physical Medicine & Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Won, Yu Hui (Department of Physical Medicine & Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Ko, Myoung-Hwan (Department of Physical Medicine & Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Seo, Jeong-Hwan (Department of Physical Medicine & Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Park, Sung-Hee (Department of Physical Medicine & Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University Hospital)
  • 투고 : 2018.03.10
  • 심사 : 2018.10.10
  • 발행 : 2018.12.31

초록

Transcranial magnetic stimulation (TMS) has been a gold standard for investigating central motor pathways in humans. Diffusion tensor imaging with fiber tractography (DTI FT) is known for its usefulness in detecting white matter lesion in vivo. We investigated the clinical usefulness of elucidating the integrity and continuity of corticospinal tract (CST) by combined use of TMS and DTI FT in this study. We report two cases who have presented with left hemiparesis and evaluated by both TMS and DTI FT; 10-year-old boy with Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episode syndrome and 20-year-old woman with traumatic brain injury. Combined use of TMS and DTI FT successfully led to localize the brain lesion that might cause motor impairment in patients with abnormal signal intensities in MRI. The results of this study suggest that TMS and DTI FT might provide the detailed information between function and anatomy of the CST, complementarily.

키워드

참고문헌

  1. Cincotta M, Ziemann U: Neurophysiology of unimanual motor control and mirror movements. Clinical Neurophysiology 2008: 119: 744-762 https://doi.org/10.1016/j.clinph.2007.11.047
  2. Assaf Y, Pasternak O: Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. Journal of molecular neuroscience 2008: 34: 51-61 https://doi.org/10.1007/s12031-007-0029-0
  3. Jang SH, Ahn SH, Sakong J, Byun WM, Choi BY, Chang CH, et al: Comparison of TMS and DTT for predicting motor outcome in intracerebral hemorrhage. Journal of the neurological sciences 2010: 290: 107-111 https://doi.org/10.1016/j.jns.2009.10.019
  4. Kwon YH, Son SM, Lee J, Bai DS, Jang SH: Combined study of transcranial magnetic stimulation and diffusion tensor tractography for prediction of motor outcome in patients with corona radiata infarct. Journal of rehabilitation medicine 2011: 43: 430-434 https://doi.org/10.2340/16501977-0793
  5. Staudt M, Grodd W, Gerloff C, Erb M, Stitz J, Krageloh-Mann I: Two types of ipsilateral reorganization in congenital hemiparesis: a TMS and fMRI study. Brain 2002: 125: 2222-2237 https://doi.org/10.1093/brain/awf227
  6. Mori S, Crain BJ, Chacko VP, Van Zijl PC: Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society 1999: 45: 265-269
  7. DiMauro S, Moraes CT: Mitochondrial encephalomyopathies. Archives of Neurology 1993: 50: 1197-1208 https://doi.org/10.1001/archneur.1993.00540110075008
  8. Stinear CM, Barber PA, Smale PR, Coxon JP, Fleming MK, Byblow WD: Functional potential in chronic stroke patients depends on corticospinal tract integrity. Brain 2006: 130: 170-180 https://doi.org/10.1093/brain/awl333
  9. Rossini PM, Barker A, Berardelli A, Caramia M, Caruso G, Cracco R, et al: Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalography and Clin Neurophysiol 1994: 91: 79-92 https://doi.org/10.1016/0013-4694(94)90029-9
  10. van Kuijk AA, Pasman JW, Hendricks HT, Zwarts MJ, Geurts AC: Predicting hand motor recovery in severe stroke: the role of motor evoked potentials in relation to early clinical assessment. Neurorehabilitation and Neural repair 2009: 23: 45-51 https://doi.org/10.1177/1545968308317578
  11. Burgel U, Amunts K, Hoemke L, Mohlberg H, Gilsbach JM, Zilles K: White matter fiber tracts of the human brain: threedimensional mapping at microscopic resolution, topography and intersubject variability. Neuroimage 2006: 29: 1092-1105 https://doi.org/10.1016/j.neuroimage.2005.08.040
  12. Cho S-H, Kim DG, Kim D-S, Kim Y-H, Lee C-H, Jang SH: Motor outcome according to the integrity of the corticospinal tract determined by diffusion tensor tractography in the early stage of corona radiata infarct. Neurosci Lett 2007: 426: 123-127 https://doi.org/10.1016/j.neulet.2007.08.049
  13. Konishi J, Yamada K, Kizu O, Ito H, Sugimura K, Yoshikawa K, et al: MR tractography for the evaluation of functional recovery from lenticulostriate infarcts. Neurology 2005: 64: 108-113 https://doi.org/10.1212/01.WNL.0000148477.65273.0C
  14. Yang Q, Tress BM, Barber PA, Desmond PM, Darby DG, Gerraty RP, et al: Serial study of apparent diffusion coefficient and anisotropy in patients with acute stroke. Stroke 1999: 30: 2382-2390 https://doi.org/10.1161/01.STR.30.11.2382
  15. Yoshioka H, Horikoshi T, Aoki S, Hori M, Ishigame K, Uchida M, et al: Diffusion tensor tractography predicts motor functional outcome in patients with spontaneous intracerebral hemorrhage. Neurosurgery 2008: 62: 97-103 https://doi.org/10.1227/01.NEU.0000311066.03121.B8
  16. Boelmans K, Kaufmann J, Schmelzer S, Vielhaber S, Kornhuber M, Munchau A, et al: Hirayama disease is a pure spinal motor neuron disorder-a combined DTI and transcranial magnetic stimulation study. J Neurol 2013: 260: 540-548 https://doi.org/10.1007/s00415-012-6674-4
  17. Hubers A, Klein JC, Kang J-S, Hilker R, Ziemann U: The relationship between TMS measures of functional properties and DTI measures of microstructure of the corticospinal tract. Brain stimulation 2012: 5: 297-304 https://doi.org/10.1016/j.brs.2011.03.008